A5102737234- Tuberculosis Research and Epidemiology
- Birth, Development, and Health
- Immune responses and vaccinations
- Fatty Acid Research and Health
- Mycobacterium research and diagnosis
- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Adipokines, Inflammation, and Metabolic Diseases
- Neuroendocrine regulation and behavior
- Immune Cell Function and Interaction
- Mesenchymal stem cell research
- Immune Response and Inflammation
- Attention Deficit Hyperactivity Disorder
- COVID-19 Clinical Research Studies
- Healthcare during COVID-19 Pandemic
- SARS-CoV-2 and COVID-19 Research
- Stress Responses and Cortisol
- Infant Nutrition and Health
- HIV Research and Treatment
- Child Nutrition and Water Access
- COVID-19 diagnosis using AI
- Infectious Diseases and Tuberculosis
- T-cell and B-cell Immunology
- Education during COVID-19 pandemic
Universidade Federal de Pernambuco
2010-2022
Universidade Federal Rural de Pernambuco
2019
Laboratoire CarMeN
2017
Inserm
2017
Creative Research Enterprises (United States)
2017
Fundação Oswaldo Cruz
2006
The Francis Crick Institute
2004
National Institute for Medical Research
2003
Host immune response against Mycobacterium tuberculosis is mediated by cellular immunity, in which cytokines and Th1 cells play a critical role. In the process of control infection mycobacteria, TNF-alpha seems to have primordial function. This cytokine acts synergy with IFN-gamma, stimulating production reactive nitrogen intermediates (RNIs), thus mediating tuberculostatic function macrophages, also migration site, contributing granuloma formation, controls disease progression. IFN-gamma...
The variable efficacy of bacillus Calmette-Guérin (Mycobacterium bovis BCG) in protecting humans and cattle against tuberculosis has prompted a search for more effective vaccination regimen. A prime-boost strategy was investigated naturally sensitized to environmental mycobacteria by using combination three DNA vaccines coding Hsp 65, 70, Apa priming, followed boost with BCG prior experimental challenge virulent M. bovis. Controls were vaccinated or alone not vaccinated. immune responses...
ABSTRACT Tuberculosis is responsible for >2 million deaths a year, and the number of new cases rising worldwide. DNA vaccination combined with Mycobacterium bovis bacillus Calmette Guérin (BCG) represents potential strategy prevention this disease. Here, we used heterologous prime-boost immunization approach using combination plasmids BCG in order to improve efficacy against tuberculosis infection mice. As model antigens, selected M. Apa (for alanine-proline-rich antigen) immunodominant...
ABSTRACT Priming neonatal calves at birth with a Mycobacterium bovis bacillus Calmette-Guérin (BCG) vaccine and boosting DNA consisting of plasmids encoding mycobacterial antigens Hsp65, Hsp70, Apa or the reverse prime-boost sequence induced similar levels protection against experimental challenge . When M. was isolated from thoracic lymph node following challenge, two groups given regimen had significantly lower numbers isolates than those vaccinated BCG alone. These observations suggest...
<i>Background/Aims:</i> Physical training is a well-known inducer of positive physiological adaptations. The effects moderate physical on the morphometry splenic lymphoid follicles endotoxemic rats submitted to perinatal low-protein (LP) diet were evaluated. <i>Methods:</i> Male Wistar divided into two groups according their mother’s (17% casein, control, C) and, undernourished (8% LP diet). On postnatal day 63, animals (8 weeks, 5 days·week<sup>–1</sup>,...
Mesenchymal stem cells from healthy adipose tissue are adipocytes progenitors with immunosuppressive potential that used for years in cell therapy. Whether (ASC) may prevent inflammation early obesity is not known. To address this question, we performed a kinetic study of high-fat (HF) diet induced mice to follow the immune regulating functions isolated subcutaneous (SAT) and visceral (VAT). Our results show that, before was detected, HF durably differently activated ASC SAT VAT....
This study evaluated the effects of a post-weaning high-fat (HF) diet on somatic growth, food consumption, metabolic parameters, phagocytic rate and nitric oxide (NO) production peritoneal macrophages in young rats submitted to maternal low-protein (LP) diet. Male Wistar (aged 60 d) were divided two groups (n 22/each) according their during gestation lactation: control (C, dams fed 17 % casein) LP (dams 8 casein). At weaning, half HF more formed (HF low protein-high fat (LP-HF)). Somatic...
Serological databases represent an important source of information to perceive COVID-19 impact on health professionals involved in combating the disease. This paper describes SerumCovid, a serological database focused diagnosis professionals, providing preliminary analysis contribute understanding antibody response SARS-CoV-2. The study population comprises 321 samples from 236 healthcare and frontline workers fighting Vitória de Santo Antão, Brazil. Samples were collected at least six days...