A5086476283- Spaceflight effects on biology
- High Altitude and Hypoxia
- Genetic diversity and population structure
- Advanced biosensing and bioanalysis techniques
- Preterm Birth and Chorioamnionitis
- Pregnancy and preeclampsia studies
- Health, Environment, Cognitive Aging
- Mitochondrial Function and Pathology
- Reproductive System and Pregnancy
- Retinal Development and Disorders
- Genetics, Aging, and Longevity in Model Organisms
- Gold and Silver Nanoparticles Synthesis and Applications
- Anesthesia and Neurotoxicity Research
- Birth, Development, and Health
- Genomics and Phylogenetic Studies
- RNA Interference and Gene Delivery
- Photosynthetic Processes and Mechanisms
Loma Linda University
2020-2023
Loma Linda University Medical Center
2020
Vanderbilt University
2020
Vanderbilt University Medical Center
2018
Many factors contribute to the health risks encountered by astronauts on missions outside Earth's atmosphere. Spaceflight-induced potential adverse neurovascular damage and late neurodegeneration are a chief concern. The goal of present study was characterize effects spaceflight oxidative in mouse brain its impact blood-brain barrier (BBB) integrity. Ten-week-old male C57BL/6 mice were launched International Space Station (ISS) for 35 days as part Space-X 12 mission. Ground control (GC)...
Problem Bacterial chorioamnionitis causes adverse pregnancy outcomes, yet host‐microbial interactions are not well characterized within gestational membranes. The decidua, the outermost region of membranes, is a potential point entry for bacteria ascending from vagina to cause chorioamnionitis. We sought determine whether paracrine communication between decidual stromal cells and macrophages shaped immune responses microbial sensing. Method study Decidual cell‐macrophage were modeled in...
The goal of the present study was to characterize acute oxidative damage in ocular structure and retinal function after exposure spaceflight, evaluate efficacy an antioxidant reducing spaceflight-induced changes retina. Ten-week-old adult C57BL/6 male mice were flown aboard ISS on Space-X 24 over 35 days, returned Earth alive. received a weekly injection superoxide dismutase mimic, MnTnBuOE-2-PyP 5+ (BuOE), before launch during their stay onboard ISS. Ground control maintained under...
It has been proposed that neuroinflammatory response plays an important role in the neurovascular remodeling brain after stress. The goal of present study was to characterize changes gene expression profiles associated with neuroinflammation, neuronal function, metabolism and stress mouse tissue. Ten-week old male C57BL/6 mice were launched International Space Station (ISS) on SpaceX-12 for a 35-day mission. Within 38 ± 4 h splashdown, returned Earth alive. Brain tissues collected analysis....
Abstract Plant mitochondria and plastids display an array of inheritance patterns varying levels heteroplasmy, where individuals harbor more than 1 version a mitochondrial or plastid genome. Organelle in plants has the potential to be quite complex can vary with plant growth, development, reproduction. Few studies have sought investigate these complicated within-individual variation using experimental crosses plants. We carried out carrot, Daucus carota L. (Apiaceae), which previously been...
The demands of deep space pose a health risk to the central nervous system that has long been concern when sending humans space. While little is known about how spaceflight affects transcription spatially in brain, greater understanding this process potential aid strategies mitigate effects on brain. Therefore, we performed GeoMx Digital Spatial Profiling mouse brains subjected either or grounded controls. Four brain regions were selected: Cortex, Frontal Corunu Ammonis I, and Dentate Gyrus....