A5060760951- Polymer Nanocomposites and Properties
- Silicone and Siloxane Chemistry
- Polymer Nanocomposite Synthesis and Irradiation
- Advanced Mathematical Modeling in Engineering
- Advanced Banach Space Theory
- Advanced Thermoelectric Materials and Devices
- Advanced Harmonic Analysis Research
- Polymer crystallization and properties
- Orthopaedic implants and arthroplasty
- Embedded Systems Design Techniques
- Low-power high-performance VLSI design
- Differential Equations and Boundary Problems
- Rare-earth and actinide compounds
- Parallel Computing and Optimization Techniques
- Thermal and Kinetic Analysis
- Hip disorders and treatments
- Immune Cell Function and Interaction
- Nonlinear Partial Differential Equations
- advanced mathematical theories
- Total Knee Arthroplasty Outcomes
- Photopolymerization techniques and applications
- Synthesis and properties of polymers
- Digestive system and related health
- Hip and Femur Fractures
- Asthma and respiratory diseases
Fukushima Medical University
2001-2025
Fujita Health University
1996-2024
Waseda University
2005-2023
Gunma Chuo Hospital
2023
Saiseikai Suita Hospital
2017-2022
Novartis (Japan)
2018-2022
Shinshu University
1996-2021
Nihon University
1985-2021
Keio University
2021
Mitsubishi Heavy Industries (Germany)
2021
Killer cell lectin-like receptor G1 (KLRG1) is an inhibitory expressed on subsets of natural killer (NK) cells and T cells, for which no endogenous ligands are known. Here, we show that KLRG1 binds three the classical cadherins (E-, N-, R-), ubiquitously in vertebrates mediate cell–cell adhesion by homotypic or heterotypic interactions. By expression cloning using mouse tetramer as a probe, identified human E-cadherin xenogeneic ligand. We also syngeneic interaction between E-cadherin....
A nonnegative nontrivial solution of the quasilinear elliptic differential equation (1.1) below on entire space is obtained. The function φ(t)t in principal part nonhomogeneous and b(t)t has critical Orlicz-Sobolev growth with respect to φ.
This article evaluates the suitability of cadavers embalmed by saturated salt solution (SSS) method for surgical skills training (SST). SST courses using have been performed to advance a surgeon's techniques without any risk patients. One important factor improving is specimens, which depends on embalming method. In addition, infectious and cost involved in are problems that need be solved. Six were 3 methods: formalin solution, Thiel (TS), SSS methods. Bacterial fungal culture tests...
The antimicrobial activities of fullerene C60 and its derivatives against 6 kinds bacteria 2 fungi were evaluated. tested samples water-soluble fullerenes (polyvinylpyrrolidone (PVP)/C60, γ-cyclodextrin (γ-CD)/C60, nano-C60) 3 types fullerenols (C60(OH)12, C60(OH)36·8H2O, C60(OH)44·8H2O). Their compared with those (+)-catechin hinokitiol from the viewpoint future application to cosmetics. Although pristine demonstrated no activity, exhibited good activity Propionibacterium acnes,...
We have examined the phase equilibrium and thermoelectric properties of Co1−xFexSb3 ternary system up to high iron context x=0.40. Traces Sb were observed in hot-pressed samples with x⩾0.06, FeSb2 (Fe0.73Co0.27Sb2) compound marcasite structure was also x⩾0.25 by x-ray diffraction. The lattice parameter is slightly larger than that binary CoSb3. Seebeck coefficient electrical resistivity are generally reduced substitution for Co Fe. thermal conductivity especially at content region. These...
Dopa-responsive dystonia (DRD) is a hereditary characterized by childhood onset of fixed dystonic posture with dramatic and sustained response to relatively low doses levodopa. DRD thought result from striatal dopamine deficiency due reduced synthesis activity tyrosine hydroxylase (TH), the synthetic enzyme for dopamine. The mechanisms underlying genesis in present challenge models basal ganglia movement control, given that hallmark Parkinson's disease. We report here behavioral anatomical...
Inflammatory bowel disease (IBD) represents a group of chronic inflammatory diseases characterized by inflammation and relapsing gastrointestinal disorders. Recent studies have shown that Th17 cells, which are well known as key mediators inflammation, pivotal role in onset development IBD humans mice, alike. In recent years, it has been reported IL-27, is an IL-12-related heterodimeric cytokine consisting EBI3 p28 subunits, act directly on naive T cells to suppress the differentiation cells....
We report and demonstrate biomedical applications of a new technique--'living' PEGylation--that allows control the density composition heterobifunctional PEG (HS-PEG-R; thiol-terminated poly(ethylene glycol)) on gold nanoparticles (AuNPs). first establish 'living' PEGylation by incubating HS-PEG₅₀₀₀-COOH with AuNPs (∼20 nm) at increasing molar ratios from zero to 2000. This causes hydrodynamic layer thickness differentially increase up 26 nm. The controlled, gradual in PEG-COOH is revealed...
Clinical experience of ceritinib in patients who progressed on alectinib is limited. In this prospective phase II study, we evaluated the activity alectinib-pretreated with anaplastic lymphoma kinase (ALK)-rearranged metastatic (stage IIIB/IV) non-small-cell lung cancer (NSCLC) Japan. All were required to have ≥1 measurable lesion per RECIST, 1.1, and a World Health Organization Performance Status (WHO PS) 0-1. Prior crizotinib and/or up 1 chemotherapy regimen was allowed. Primary endpoint...
The phase equilibrium and thermoelectric properties of Co1−xNixSb3 ternary system were examined up to high nickel content x=0.40. NiSb compound with arsenide structure was observed as the impurity in samples x>0.10 by x-ray diffraction. sign Seebeck coefficient is negative, absolute value electrical resistivity generally decreases increasing x. thermal conductivity reduced x⩽0.06, but above x=0.06 it increases These behaviors low are ascribed substituted Ni, while those precipitated...
Peritoneal fluid in women with endometriosis contains an increased number of activated macrophages that secrete a variety cytokines, including interleukin (IL)-6, IL-8, vascular endothelial growth factor, and tumor necrosis factor-α (TNF-α). Cytokines may be involved the control implantation endometrial cells outside uterus. In addition, several cytokines have been implicated or directly associated angiogenic activity endometriosis. There could relationship between levels peritoneal patients...
Background The controlling nutritional status (CONUT) score (CS), a simple for assessing status, is calculated using laboratory data, including serum albumin concentration. Although dye-binding assays such as the bromocresol green (BCG) and modified purple (mBCP) methods are widely used measurement, acute-phase proteins interfere with BCG method. Objective We aimed to determine whether choice of assay affects assessment CONUT scores (CSs). Design measured concentrations by (ALB ) mBCP in 44...
Aim Senior surgeons in Japan who participated “cadaver‐based educational seminar for trauma surgery ( CESTS )” subsequently stated their interest seminars more difficult procedures. Therefore, we held a 1‐day advanced‐ with saturated salt solution SSS )‐embalmed cadavers and assessed its effectiveness surgical skills training SST ). Methods Data were collected from three carried out September 2015 to January 2018, including 10‐point self‐assessment of confidence levels SACL ) questionnaire...
Key points The contribution of HCN4 pacemaker channels in the autonomic regulation sino‐atrial node (SAN) has been a matter debate. transgenic overexpression did not induce tachycardia, but reduced heart rate variability, while conditional knockdown gave rise to sinus arrhythmia. response SAN β‐adrenergic stimulation was affected by or channels. When were knocked down, parasympathetic examined cervical vagus nerve (CVNS) enhanced; CVNS induced complete pause. attenuated bradycardia only...
A von Willebrand factor (vWF)-binding and -cleaving metalloproteinase, termed "kaouthiagin", was purified from the venom of cobra snake Naja kaouthia. Kaouthiagin is a monomer with molecular mass about 46 kDa 51 under non-reducing reducing conditions, respectively, N-terminal amino acid sequence homologous to high metalloproteinases. bound vWF in divalent ion-independent manner, but reduced kaouthiagin failed interact vWF, suggesting that protein conformation maintained by...
Power efficient SoC design for embedded applications requires several independent power-domains where the power of unused blocks can be turned off. An mobile phones defines 23 hierarchical domains but most are assigned peripheral IPs that mainly use low-leakage high-V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">t</sub> transistors. Since high-performance multiprocessor SoCs leaky low-V transistors CPU sections, leakage savings these sections...
A 648 MHz 153.8 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> 45 nm CMOS SoC integrates eight general-purpose CPUs, four dynamically reconfigurable processors, two 1024-way matrix-processors, peripherals and interfaces. Using core enhancement, DDR3-I/F improvement clock buffer deactivation, this achieves 37.3 GOPS/W at 1.15 V.