A5054416169- Cervical Cancer and HPV Research
- Global Cancer Incidence and Screening
- Colorectal Cancer Screening and Detection
- COVID-19 and healthcare impacts
- Genetic factors in colorectal cancer
- Endometrial and Cervical Cancer Treatments
- Lymphadenopathy Diagnosis and Analysis
- Genital Health and Disease
- Gynecological conditions and treatments
- Adenosine and Purinergic Signaling
- Colorectal Cancer Treatments and Studies
- AI in cancer detection
- Hepatitis B Virus Studies
- Ethics in Clinical Research
- Animal Virus Infections Studies
- Cancer Genomics and Diagnostics
- Colorectal and Anal Carcinomas
- Nitric Oxide and Endothelin Effects
- Neuroscience of respiration and sleep
Cancer Council NSW
2019-2025
The University of Sydney
1997-2025
St Vincent's Hospital Sydney
1997
In May, 2018, the Director-General of WHO issued a global call to eliminate cervical cancer as public health problem, which will involve ambitious screening and vaccination coverage targets. We aimed assess potential for, timing of, elimination in USA whether this could be expedited by adopting targets, using two simulation models.In modelling study, we used independently-developed microsimulation models-Harvard Policy1-Cervix-to estimate changes incidence human papillomavirus (HPV)-induced...
Importance Cervical screening guidelines in the US recommend that most females can exit routine at age 65 years following 2 recent consecutive negative cotest results (concurrent human papillomavirus and cytology tests). However, empirical data on subsequent risks of cancer death this subgroup are limited. Objective To estimate cervical among who meet cotesting criteria to screening. Design, Setting, Participants In decision analytical comparative modeling study, 4 models from Cancer...
Abstract Background The natural history of human papillomavirus (HPV)-induced cervical cancer (CC) is not directly observable, yet the age HPV acquisition and duration preclinical disease (dwell time) influences effectiveness alternative preventive policies. We performed a Cancer Intervention Surveillance Modeling Network (CISNET) comparative modeling analysis to characterize cancer-causing infections implied dwell times for distinct phases carcinogenesis. Methods Using four CISNET-cervical...
Background A nonavalent human papillomavirus (HPV) vaccine has been licensed for use in women and men up to age 45 years the United States. The cost-effectiveness of HPV vaccination aged 30 context cervical cancer screening practice was evaluated inform national guidelines. Methods findings We utilized 2 independent microsimulation models evaluate extending upper limit (from 26 years) 21 30, 35, 40, or years. were empirically calibrated reflect burden related cancers US population used...
Population-level estimates in timeframes for reaching cervical cancer (CC) elimination (ie, <4 cases per 100,000 women) the United States may mask potential disparities achieving among sub-populations. We used three independent Cancer Intervention and Surveillance Modeling Network (CISNET) models to estimate differences time CC across seven strata of correlated screening human papillomavirus vaccination uptake, based on national survey data. Compared average population, was achieved ≥22...
Objectives To evaluate the health impact and cost-effectiveness of systematic testing for Lynch syndrome (LS) in people with incident colorectal cancer (CRC) Australia. Design, setting, participants We investigated LS strategies a micro-simulation model (Policy1–Lynch), explicitly modelling cost all patients diagnosed CRC during 2017, detailed outcomes identified as carriers (probands) their at-risk relatives throughout lifetimes. For confirmed LS, we modelled ongoing colonoscopic...
1. We have identified the P2 receptors mediating vasomotor responses in rabbit pulmonary artery. 2. Neither ATP nor UTP contracted intact or endothelium-denuded rings. However, both relaxed rings of artery that had been preconstricted with phenylephrine (pD2 5.2 and 5.6, respectively). 3. The vasodilator effect was endothelium-dependent abolished by nitric oxide synthase inhibitor NG-nitro-L-arginine (L-NOARG). 4. only partially inhibited removal endothelium addition L-NOARG, suggesting an...
Background. To interpret cervical cancer screening model results, we need to understand the influence of structure and assumptions on incidence mortality predictions. Cervical cases deaths following can be attributed 1) (precancerous or cancerous) disease that occurred after screening, 2) was present but not screen detected, 3) detected successfully treated. We examined relative contributions each these using 4 Cancer Intervention Surveillance Modeling Network (CISNET) models. Methods. The...
We evaluated how temporary disruptions to primary cervical cancer (CC) screening services may differentially impact women due heterogeneity in their history and test modality. used three CC models project the short- long-term health impacts assuming an underlying frequency (i.e., 1, 3, 5, or 10 yearly) under alternative COVID-19-related disruption scenarios 1-, 2-, 5-year delay) versus no delay context of both cytology-based human papillomavirus (HPV)-based screening. Models projected a...
COVID-19 disrupted school attendance in many countries, delaying routine adolescent vaccination against human papillomavirus (HPV) some settings. We used Policy1-Cervix , a dynamic model simulating HPV transmission, natural history, vaccination, cervical screening, and diagnosis of HPV-related cancers, to estimate the impact on cancers from disruptions high-income setting. A baseline scenario no disruption was modelled, which assumed uptake nonavalent vaccine at age 12 by 82.4% females 75.5%...
Abstract COVID-19 disrupted school attendance in many countries, delaying routine adolescent vaccination against human papillomavirus (HPV) some settings. We used the ‘ Policy1-Cervix’ HPV model (natural history/vaccination/screening/HPV-related cancers), to estimate impact on HPV-related cancers from disruptions a high-income setting. Compared no disruption (nonavalent vaccine uptake, age 12 [females:82.4%; males:75.5%] as Australia), additional lifetime cancer cases were calculated for...
ABSTRACT Background We evaluated how temporary disruptions to primary cervical cancer (CC) screening services may differentially impact women due heterogeneity in their history and test modality. Methods used three CC models project the short- long-term health impacts assuming an underlying frequency (i.e., 1, 3, 5, or 10 yearly) under alternative COVID-19-related disruption scenarios 1-, 2- 5-year delay) versus no delay, context of both cytology-based HPV-based screening. Results Models...