A5034908074- Genetic factors in colorectal cancer
- Cervical Cancer and HPV Research
- Colorectal Cancer Screening and Detection
- Global Cancer Incidence and Screening
- Renal Transplantation Outcomes and Treatments
- Colorectal and Anal Carcinomas
- Endometrial and Cervical Cancer Treatments
- BRCA gene mutations in cancer
- Renal Diseases and Glomerulopathies
- Health Systems, Economic Evaluations, Quality of Life
- Cytomegalovirus and herpesvirus research
- Genital Health and Disease
- Hepatitis B Virus Studies
- Cutaneous Melanoma Detection and Management
- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- Dialysis and Renal Disease Management
- Parathyroid Disorders and Treatments
- Genetic Associations and Epidemiology
- Polyomavirus and related diseases
- Lung Cancer Diagnosis and Treatment
- Mycobacterium research and diagnosis
- Esophageal Cancer Research and Treatment
- Reproductive tract infections research
- Art Education and Development
Cancer Council NSW
2011-2025
The University of Sydney
2015-2025
Soonchunhyang University
2023
Cancer Council Australia
2019
Pusan National University Hospital
2017-2019
John Wiley & Sons (United States)
2017
Ewha Womans University Medical Center
2015
UNSW Sydney
2015
Kyungpook National University Hospital
2012-2014
Kyungpook National University
2013-2014
BackgroundAustralia's National Cervical Screening Program currently recommends cytological screening every 2 years for women aged 18–69 years. Human papillomavirus (HPV) vaccination was implemented in 2007 with high population coverage, and falls high-grade lesions young have been reported extensively. This decline prompted a major review of the new clinical management guidelines, which we undertook this analysis.MethodsWe did effectiveness modelling an economic assessment potential...
Background Previous studies have reported that anal cancer incidence has increased in individual countries; however, age-specific trends were not examined detail. This study describes pooled and country-specific by sex, age (all ages, <60 60+ years) histological subtype subtypes, squamous cell carcinoma [SCC] adenocarcinoma [ADC]). Methods Five-year population-at-risk data obtained from IARC’s Cancer Incidence Five Continents for the years 1988–1992 to 2008–2012. The standardised rate ratios...
The aim of this study was to assess trends in the age‐specific incidence vulvar cancer 13 high‐income countries satisfying a priori conditions regarding availability registry data over 20‐year period; these were Canada, United States, nine European countries, Australia and Japan. Five‐yearly population at risk obtained from International Agency for Research on Cancer's Cancer Incidence Five Continents years 1988–1992 (Volume 7) 2003–2007 10). 5‐yearly average percent change (AvPC) period...
Abstract With increasing availability of genetic tests, it is important to consider differences in testing patterns between population subgroups. We examined self-reported among 45,061 participants the Australian population-based 45 and Up Study, for associations with sociodemographic health characteristics (multivariable logistic regression). 9.2% reported ever having testing; 3.9% disease-related testing, 5.2% non-disease-related 0.7% both testing. Disease-related was strongly associated...
Rationale: The NLST (National Lung Screening Trial) reported a 20% reduction in lung cancer mortality with low-dose computed tomography screening; however, important questions on how to optimize screening remain, including which selection criteria are most accurate at detecting cancers and what nodule management protocol is efficient. PLCOm2012 (Prostate, Lung, Colorectal Ovarian) Cancer Trial 6-year PanCan (Pan-Canadian Early Detection of Cancer) malignancy risk models two the better...
Abstract Background A new lower-cost rapid-throughput human papillomavirus (HPV) test ( care HPV, Qiagen, Gaithersburg, USA) has been shown to have high sensitivity for the detection of grade cervical intraepithelial neoplasia. Methods We assessed outcomes and cost-effectiveness HPV screening in rural China, compared visual inspection with acetic acid, when used alone (VIA) or combination Lugol's iodine (VIA/VILI). Using data on sexual behaviour, accuracy, diagnostic practices costs from...
The objective of this study was to assess trends in vulvar cancer incidence and mortality Australia.Case numbers for invasive carcinoma the vulva (1982-2009) deaths (1982-2011) were obtained from National Cancer Statistics database. Standardized rate ratios (SRRs) used changes age-standardized rates, all ages younger than 60 years 60+ years.Age-standardized rates women across did not significantly change 1982-1984 2007-2009 (from 2.1 2.5 per 100,000 women; SRR later earlier period, 1.13 [95%...
Introduction:There are three government-funded population-based screening programs in Australia -the national breast cancer program (BreastScreen Australia), the National Cervical Screening Program (NCSP), and Bowel Cancer (NBCSP).Options for early detection of other cancers (e.g.hepatocellular carcinoma melanoma) under investigation.This study provides an overview health benefits, harms cost-effectiveness population-level breast, cervical colorectal screening, targeted-risk lung Lynch...
Objectives To evaluate the health impact and cost-effectiveness of systematic testing for Lynch syndrome (LS) in people with incident colorectal cancer (CRC) Australia. Design, setting, participants We investigated LS strategies a micro-simulation model (Policy1–Lynch), explicitly modelling cost all patients diagnosed CRC during 2017, detailed outcomes identified as carriers (probands) their at-risk relatives throughout lifetimes. For confirmed LS, we modelled ongoing colonoscopic...
Recurrence of focal segmental glomerulosclerosis (FSGS) is a major therapeutic challenge in kidney transplantation (KT). Although intensive plasmapheresis and high-dose rituximab have been introduced to treat recurrent FSGS, the most effective dosage regimen not determined. Herein we reported first case successful treatment FSGS with low-dose rituximab. The patient showed marked proteinuria (3.5 g/d) oliguria 2 d after KT. Two courses immunoglobulin were applied patient, however, nephrotic...
Objective Skin cancer is Australia’s most common and costly cancer. We examined the frequency of Australian general practice consultations for skin cancer-related conditions, by patient practitioner (GP) characteristics time period. Design Nationally representative, cross-sectional survey clinical activity. Setting, participants Patients aged 15 years or older having a condition managed GPs in Bettering Evaluation And Care Health study between April 2000 March 2016. Primary outcome measures...
No previous health-economic evaluation has assessed the impact and cost-effectiveness of offering combined adult population genomic screening for mutliple high-risk conditions in a national public healthcare system.
The case of an early retroperitoneal abdominal pregnancy implanted on inferior vena cava successfully resected through laparoscopic surgery is reported here. A 28-year-old woman presented with vaginal spotting and amenorrhrea for 7+5 weeks. Although a diagnosis right cornual ectopic by transvaginal ultrasound was made wedge resection the left uterine cornus performed, β-human chorionic gonadotropin level remained high. Abdominal ultrasonography computerized tomography abdomen demonstrated...
Abstract Background The optimal duration of antiviral therapy for kidney transplant recipients ( KTR ) with chronic hepatitis B virus HBV infection remains unclear. We reported the long‐term outcomes after withdrawal agent in infection. Methods retrospectively investigated surface antigen HB sAg)‐positive agents between January 2002 and 2012. Antiviral treatments were withdrawn patients who met all following 7 criteria: (i) no clinical histologic evidence cirrhosis, (ii) normal liver...
Lynch syndrome (LS) is an inherited, cancer predisposition associated with increased risk of colorectal, endometrial and other types. Identifying individuals LS allows access to management strategies proven reduce incidence improve survival. However, underdiagnosed genetic referral rates are poor. Improving complex, requires multisystem behaviour change. Although barriers have been identified, evidence-based facilitate change lacking. The aim this study compare the effectiveness a...
The National Cervical Screening Program in Australia currently recommends that women aged 18-69 years are screened with conventional cytology every 2 years. Publicly funded HPV vaccination was introduced 2007, and partly as a consequence, renewal of the screening program includes review recommendations has recently been announced. This study aimed to provide baseline for such by quantifying resource utilisation costs 2010.A detailed model current cervical practice constructed we used data...
To inform effective genomic medicine strategies, it is important to examine current approaches and gaps in well-established applications. Lynch syndrome (LS) causes 3-5% of colorectal cancers (CRCs). While guidelines commonly recommend LS tumour testing all CRC patients, implementation health systems known be highly variable. provide insights on the heterogeneity practice bottlenecks a high-income country with universal healthcare, we characterise referral seven Australian hospitals across...