A5083515412- Analytical Chemistry and Chromatography
- Microfluidic and Capillary Electrophoresis Applications
- Innovative Microfluidic and Catalytic Techniques Innovation
- Analytical Methods in Pharmaceuticals
- Analytical chemistry methods development
- Antibiotics Pharmacokinetics and Efficacy
- Natural product bioactivities and synthesis
- Mass Spectrometry Techniques and Applications
- Alzheimer's disease research and treatments
- Sesquiterpenes and Asteraceae Studies
- Electrochemical Analysis and Applications
- Traditional Chinese Medicine Analysis
- Neurological Disease Mechanisms and Treatments
- Phytochemistry and Biological Activities
- Pharmacological Effects and Assays
- Advanced Neuroimaging Techniques and Applications
- Parkinson's Disease Mechanisms and Treatments
- Biochemical Analysis and Sensing Techniques
- Pesticide Residue Analysis and Safety
- Molecular spectroscopy and chirality
- Plant Toxicity and Pharmacological Properties
- Functional Brain Connectivity Studies
- Advanced Chemical Sensor Technologies
- Berberine and alkaloids research
- Educational Reforms and Innovations
Shenyang Pharmaceutical University
2015-2025
Soochow University
2022-2024
Second Affiliated Hospital of Soochow University
2022-2024
Powerchina Huadong Engineering Corporation (China)
2023
PowerChina (China)
2023
Guilin University of Technology
2023
Qilu Hospital of Shandong University
2023
Nanjing Medical University
2022
Xuzhou Medical College
2022
Second People’s Hospital of Huai’an
2022
In this study, the enantioseparation of zopiclone, repaglinide, chlorphenamine maleate, brompheniramine dioxopromethazine hydrochloride, promethazine liarozole, carvedilol, homatropine hydrobromide, methylbromide, venlafaxine, and sibutramine hydrochloride has been investigated using β‐ CD in combination with a chiral ionic liquid ( IL ), 1‐ethyl‐3‐methylimidazolium‐L‐lactate. The influence type its concentration, BGE p H , chain length cations on resolution are discussed. Finally, proposed...
ABSTRACT In the present study, hydroxypropyl‐β‐cyclodextrin and an ionic liquid (1‐ethyl‐3‐methylimidazolium‐ l ‐lactate) were used as additives in capillary electrophoresis for enantioseparation of 10 analytes, including ofloxacin, propranolol hydrochloride, dioxopromethazine isoprenaline chlorpheniramine maleate, liarozole, tropicamide, amlodipine benzenesulfonate, brompheniramine homatropine methylbromide. The effects concentrations, salt effect, cations, anions liquids on investigated...
A novel single-isomer cyclodextrin derivative, heptakis {2,6-di-O-[3-(1,3-dicarboxyl propylamino)-2-hydroxypropyl]}-β-cyclodextrin (glutamic acid-β-cyclodextrin) was synthesized and used as a chiral selector in capillary electrophoresis for the enantioseparation of 12 basic drugs, including terbutaline, clorprenaline, tulobuterol, clenbuterol, procaterol, carvedilol, econazole, miconazole, homatropine methyl bromide, brompheniramine, chlorpheniramine pheniramine. The primary factors...
Fenbuconazole, a chiral triazole fungicide, is produced and used as racemate. Previous toxicological research on fenbuconazole in nontarget organisms primarily the racemate, necessitating an investigation into each enantiomer's distribution elimination for safety assessment. In this study, absolute configurations of enantiomers were first confirmed by ECD, designating them S-(+)-fenbuconazole R-(-)-fenbuconazole based their optical activity. The UHPLC-QQQ/MS method was selected to...
Chiral separation and pharmacokinetic study of antihistamine drugs.
Background Alzheimer’s disease (AD) is a complex neurodegenerative disorder characterized by progressively worsening cognitive decline and memory loss. Excessive iron accumulation produces severe impairment. However, there are no uniform conclusions about changes in brain content AD. This study aimed to investigate the of deep nuclei AD, its correlation with function. Methods Thirty-one patients mild moderate 17 impairment (MCI), 20 age-, sex-, education-matched healthy controls (HC) were...
Abstract A novel open‐tubular capillary electrochromatography column coated with β ‐cyclodextrin was prepared using the sol‐gel technique. In approach, owing to three‐dimensional network of and strong chemical bond between stationary phase surface columns, good chromatographic characteristics unique selectivity in separating enantiomers were shown. The influences inner diameter, coating time, organic modifier, buffer pH, concentration on separation investigated. sol‐gel‐coated has shown...
An open-tubular capillary electrochromatography column was prepared by chemically immobilized β-cyclodextrin modified gold nanoparticles onto new surface with the prederivatization of (3-mercaptopropyl)-trimethoxysilane. The synthesized and were characterized transmission electron microscopy, scanning infrared spectroscopy ultraviolet visible spectroscopy. When employed as chiral stationary phase, no enantioselectivity observed for ten model basic drugs. So added to background electrolyte...
The enantioseparation of twelve pairs structurally related 1-aryl-1-indanone derivatives was studied in the normal-phase mode using three different polysaccharide-type chiral stationary phases, namely Chiralpak IB, IC, and ID. n-Hexane/2-propanol n-hexane/ethanol were employed as mobile phases. Among all investigated columns, IC exhibited most universal best ability toward racemates, particularly with phase composed n-hexane/2-propanol (90/10, v/v). Then effects column temperature on...