A5036480745- Terahertz technology and applications
- Microfluidic and Bio-sensing Technologies
- Spectroscopy and Laser Applications
- Microfluidic and Capillary Electrophoresis Applications
- thermodynamics and calorimetric analyses
- Spectroscopy and Quantum Chemical Studies
- Infant Nutrition and Health
- Olfactory and Sensory Function Studies
- EEG and Brain-Computer Interfaces
- Diabetes Management and Research
- Hand Gesture Recognition Systems
- Characterization and Applications of Magnetic Nanoparticles
- Neuroscience and Neuropharmacology Research
- Digital Imaging in Medicine
- Neuroscience and Neural Engineering
- Nanopore and Nanochannel Transport Studies
- Autophagy in Disease and Therapy
- Telomeres, Telomerase, and Senescence
- Magnetic Field Sensors Techniques
- Acoustic Wave Resonator Technologies
- Pluripotent Stem Cells Research
- Plant Pathogens and Resistance
- Microbial Inactivation Methods
- Insect and Arachnid Ecology and Behavior
- Cancer Cells and Metastasis
Daegu Gyeongbuk Institute of Science and Technology
2017-2022
Government of the Republic of Korea
2020
Samsung (South Korea)
2012-2017
Sungkyunkwan University
2013
University of Rochester
1996
Centre National de la Recherche Scientifique
1989
Institut Laue-Langevin
1989
Circulating tumor cells (CTCs) have gained increasing attention as physicians and scientists learn more about the role these extraordinarily rare play in metastatic cancer. In developing CTC technology, critical criteria are high recovery rates purity. Current isolation methods suffer from an inherent trade-off between two goals. Moreover, ensuring minimal cell stress robust reproducibility is also important for clinical application of CTCs. this paper, we introduce a novel technology using...
Understanding cancer heterogeneity is essential to finding diverse genetic mutations in metastatic cancers.Thus, it critical isolate all types of CTCs identify accurate information from patients.Moreover, full automation robustly capturing the spectrum an urgent need for CTC diagnosis be routine clinical practice.Methods: Here we report capture heterogeneous populations using fully automated, negative depletion-based continuous centrifugal microfluidics (CCM).Results: The CCM system...
This study shows that the hydrophobic lung surfactant proteins (SP)-B and SP-C are not synergistic in enhancing functionally relevant surface behaviors films dispersions with phospholipids, SP-B is more effective than facilitating activity. Purified bovine SP-B, SP. C, or SP-B/C (1/1 by wt) were combined chroma tographically purified calf phospholipids (PPL), dipalmitoyl phosphatidylcholine (DPPC) complex phospholipid mixtures containing 75% 50% DPPC (75% SPL SPL). Adsorption was...
The benefits conferred by the thermal stability, very low detection limit, and high sensitivity of planar Hall effect (PHE) sensors have supported up-to-date diversity applications like nT magnetometer, current sensing, or magnetic moments in lab-on-a-chip devices. Herein, we demonstrate this review implications linked to sensors, initiating from backbone PHE its evolution throughout recent few decades. Key parameters affecting sensors' performance such as noise different sources,...
Abstract Circulating tumor cells (CTCs), though exceedingly rare in the blood, are nonetheless becoming increasingly important cancer diagnostics. Despite this keen interest and growing number of potential clinical applications, there has been limited success developing a CTC isolation platform that simultaneously optimizes recovery rates, purity, cell compatibility. Herein, novel tracheal carina‐inspired bifurcated (TRAB) microfilter system is reported, which uses an optimal filter gap size...
We investigate the utility of terahertz (THz) spectroscopy in identifying Alzheimer's disease human brain tissue. Using reflection-mode time-domain THz spectroscopy, two-dimensional images formalin-fixed and paraffin-embedded tissue samples hippocampus area were recorded 60 GHz-2 band. The compared with microscopic same after hematoxylin eosin staining. demonstrate that reflection spectra, particularly from white matter, reveal detectable differences between postmortem tissues exhibiting...
We propose a novel method for identifying and classifying motions that offers significantly reduced computational cost as compared to deep convolutional neural network systems with comparable performance. Our new approach is inspired by the information processing architecture of biological visual systems, whereby spatial pyramid kernel features are efficiently extracted in real-time from temporally-differentiated image data. In this paper, we describe evaluate its performance hand motion...
To precisely purify and study aged (senescent) cells, we have designed, fabricated, demonstrated a novel diamond-structure (DS) microfluidic filter. Nonuniform flow velocities within the microfilter channel can compromise filter performance, but with this new diamond structure, further optimized via simulation, achieve uniform field, improving throughput of size-based separation senescent as obtained by 39-passaged human dermal fibroblasts. After separating these cells into two groups,...
We investigate the use of real-time THz camera imaging for differentiating between benign and malignant tissues in major human tissue groups. Using broadband time-domain spectroscopy, we discriminate tumor nerve margins on basis different refractive indices reflectivity. Particular focus is given to easily accessible malignancies, such as skin, larynx, esophagus, colon cancers. Time domain response due chemistry morphology recorded tabulated create a "THz database" that can be used reference...
We investigate the THz response of human brain tissue exhibiting Alzheimer's disease. Amyloid plaque buildup, believed to be a possible cause this disease, is typically diagnosed by immunohistochemical inspection beta-amyloid in ex vivo biopsy specimens. Using broadband time domain spectrometer system reflection mode imaging, we demonstrate possibility discriminating between major components, including white and grey matter as based on their morphological compositional differences. More...
Pipetting techniques play a crucial role in obtaining reproducible and reliable results, especially when seeding cells on small target areas, such as microarrays, biochips or microfabricated cell culture systems. For very rare cells, human primary skeletal muscle (skMCs), manual (freehand) invariably result nonuniform spreading heterogeneous densities, giving rise to undesirable variations myogenesis differentiation. To prevent technique-dependent variation, we have designed fabricated...
Invasive bioelectrodes are widely used as an effective treatment for several acute and chronic diseases. In earlier work using high surface area invasive porous evaluated in animal model of alcoholism withdrawal, we demonstrated significantly improved electrophysiological behavioral responses. this study, further modify the these with noble metal (Ag, Au, Pt) nanoparticles. Compared to both conventional bioelectrodes, sensitized show markedly increased low threshold (LT) wide dynamic range...
Summary form only given. The sensitivity of THz waves to tissue hydration levels in excised specimen enables clinical, in-situ discrimination cancerous vs. normal regions (Z. D. Taylor et al., IEEE Trans. Terahertz Sci. Technol., 1(1), 201-219, 2011 and M. H. Arbab J. Biomed. Opt., 18(7), 077004, 2013). However, previous studies on biomedical imaging human groups have been largely disconnected, with publications focusing a few at time. In addition, assessment cancer margins differentiate...
The distinction between the medical and surgical approach to disease has been a cornerstone of practice, indeed with respect business technology medicine. It is common knowledge that diabetes disease—namely drug therapy, whether it be via insulin or other medications, primary therapy. This article argues reevaluation generalized (e.g., medication-based) systemic blood sugar control may in order. A consideration growing importance interventional, device-based, approaches management enormous...
In isolating circulating tumor cells (CTCs), which exist in extremely low concentrations the blood, current methods have been limited by a trade-off between recovery rate and purity. To overcome this challenge, M. S. Kim, Lee, J.-G. co-workers present on page 3103 sized-based filtration method that combines two strategies: (1) using specific binding of solid microbeads conjugated with anti-EpCAM antibodies to enhance discrimination CTCs from other blood constituents (mainly white cells)...
We report on the development of a high-resolution (<; 1 GHz at 1.0 THz), broadly-tunable (~0.5 - 3.0 THz) fiber MOPA-based terahertz spectrometer system. The flexibility and performance this system will be demonstrated with gaseous (water vapor) aqueous solvated protein) samples view towards selectively non-destructively probing functionally significant large-scale protein motions.