A5002934530- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Gold and Silver Nanoparticles Synthesis and Applications
- Photoacoustic and Ultrasonic Imaging
- Advanced biosensing and bioanalysis techniques
- Advanced Cellulose Research Studies
- Additive Manufacturing and 3D Printing Technologies
- Extracellular vesicles in disease
- RNA Interference and Gene Delivery
- Electrospun Nanofibers in Biomedical Applications
- Photopolymerization techniques and applications
- Advanced Sensor and Energy Harvesting Materials
- Graphene and Nanomaterials Applications
- Characterization and Applications of Magnetic Nanoparticles
- Bladder and Urothelial Cancer Treatments
- Iron oxide chemistry and applications
- Click Chemistry and Applications
- Lanthanide and Transition Metal Complexes
- Carbon and Quantum Dots Applications
- Protease and Inhibitor Mechanisms
- biodegradable polymer synthesis and properties
- Bone Tissue Engineering Materials
- Multicomponent Synthesis of Heterocycles
- Dielectric materials and actuators
- Medical Imaging Techniques and Applications
University of Bologna
2016-2025
Weatherford College
2021
Institute for Experimental Endocrinology and Oncology
2021
University of Louisville
2019
Aim: Targeted biocompatible nanoplatforms presenting multiple therapeutic functions have great potential for the treatment of cancer. Materials & methods: Multifunctional nanocomposites formed by polymeric nanoparticles (PNPs) containing two cytotoxic agents – drug alisertib and silver were synthesized. These PNPs been conjugated with a chlorotoxin, an active targeting 36-amino acid-long peptide that specifically binds to MMP-2, receptor overexpressed brain cancer cells. Results: The...
Polymeric nanoparticles (PNPs) may efficiently deliver in vivo therapeutics to tumors when conjugated specific targeting agents. Gint4.T aptamer specifically recognizes platelet-derived growth factor receptor β and can cross the blood-brain barrier (BBB). We synthesized Gint4.T-conjugated PNPs able of high uptake into U87MG glioblastoma (GBM) cells with astonishing EC50 value (38 pM) loaded a PI3K-mTOR inhibitor. also demonstrated BBB passage tumor accumulation GBM orthotopic model.
Abstract Background Management of triple-negative breast cancer (TNBC) is still challenging because its aggressive clinical behavior and limited targeted treatment options. Cisplatin represents a promising chemotherapeutic compound in neoadjuvant approaches the metastatic setting, but use by scarce bioavailability, severe systemic side effects drug resistance. Novel site-directed aptamer-based nanotherapeutics have potential to overcome obstacles chemotherapy. In this study we investigated...
Glioblastoma multiforme (GBM) is the most aggressive form of glioma, with life expectancy around 2 years after diagnosis, due to recidivism and blood-brain barrier (BBB) limiting amount drugs which reach residual malignant cells, thus contributing failure chemotherapies. To bypass obstacles imposed by BBB, we investigated use nanotechnologies combined radiotherapy, as a potential therapeutic strategy for GBM. We used poly(lactic-co-glycolic acid) (PLGA) nanoparticles (PNP) conjugated...
Surface modification of gold nanorods allows biocompatibility and complex architecture design for novel theranostic applications.
In this work, iron/silica/gold core-shell nanoparticles (Fe3O4@SiO2@Au NPs) characterized by magnetic and optical properties have been synthesized to obtain a promising theranostic platform. To improve their biocompatibility, the obtained multilayer entrapped in polymeric micelles, decorated with folic acid moieties, tested vivo for photoacoustic resonance imaging detection of ovarian cancer.
We report on the fabrication and electro-mechanical characterization of a nanocomposite system exhibiting anisotropic electrical response under application tactile compressive stresses (5 kPa) at low frequencies (0.1-1 Hz). The is based chemically cross-linked gel incorporating highly conductive ionic liquid surface functionalized barium titanate (BaTiO3) ferroelectric nanoparticles. was engineered to respond mechanical stimulations by combining piezoionic piezoelectric activity, generating...
Glioblastoma multiforme (GBM) is the most aggressive primary tumor of central nervous system and diagnosis often dismal. GBM pharmacological treatment strongly limited by its intracranial location beyond blood-brain barrier (BBB). While Temozolomide (TMZ) exhibits best clinical performance, still less than 20% crosses BBB, therefore requiring administration very high doses with resulting unnecessary systemic side effects. Here, we aimed at designing new negative temperature-responsive gel...
Abstract The limitations of current diagnostic imaging techniques and therapies for bladder cancer are associated with responsible the recurrence progression residual disease, an impact on social costs quality life patients. This study delivers a cost‐effective solution detection which is represented by early lesions < 1 mm. Urine‐stable 34‐mer SH‐terminated 2′F‐Py‐RNA aptamer that recognizes integrin α5β1, expressed 81% human high‐grade non‐muscle invasive cancer, developed. intravesical...
Abstract: A novel nanocarrier system was designed and developed with key components uniquely structured at the nanoscale for early cancer diagnosis treatment. In order to perform magnetic resonance imaging, hydrophilic superparamagnetic maghemite nanoparticles (NPs) were synthesized coated a lipophilic organic ligand. Next, they entrapped into polymeric NPs made of biodegradable poly(lactic-co-glycolic acid) linked polyethylene glycol. addition, resulting have been conjugated on their...
Small interfering RNA (siRNA) therapies require effective delivery vehicles capable of carrying the siRNA cargo into target cells. To achieve tumor-targeting, a drug system would have to incorporate ligands that specifically bind receptors expressed on cancer cells function as portals via receptor-mediated endocytosis. Cell-targeting and internalizing aptamers are most suitable for functionalization drug-loaded nanocarriers. Here, we designed novel aptamer-based platform active targeting...
Vat photopolymerization, a very efficient and precise object manufacturing technique, still strongly relies on the use of acrylate- methacrylate-based formulations because their low cost high reactivity. However, environmental impact using fossil fuel-based, volatile, toxic (meth)acrylic acid derivatives is driving scientific community toward development alternatives that can match mechanical performance three-dimensional (3D) printing processability traditional photocurable mixtures but are...
Metal oxide nanoparticles, hybridized with various polymeric chemicals, represent a novel and breakthrough application in drug delivery, hyperthermia treatment imaging techniques. Radiolabeling of these nanoformulations can result new attractive dual-imaging agents as well provide accurate vivo information on their biodistribution profile. In this paper comparison study has been made between two the most promising hybrid core–shell nanosystems, bearing either magnetite (Fe3O4) or cobalt...
Abstract MRE11 is a component of the MRE11/RAD50/NBS1 (MRN) complex, whose activity essential to control faithful DNA replication and prevent accumulation deleterious double-strand breaks. In humans, hypomorphic mutations in these genes lead damage response (DDR)-defective cancer-prone syndromes. Moreover, MRN complex dysfunction dramatically affects nervous system, where required restrain MYCN-dependent stress, during rapid expansion progenitor cells. MYCN activation, often due genetic...
Cancer stem cells (CSCs) present a higher capacity to evade being killed by cancer agents and developing chemoresistance, thus leading failure of conventional anticancer therapeutics. Nanomaterials specifically designed for targeting treating not only tumor cells, but also CSCs, may encompass therapeutic diagnostic tools, successfully eradicating the tumor.Polymeric micelles simultaneously loaded with gold nanorods (GNRs) Adriamycin were prepared used as novel weapon. Epithelial cell...
This work presents a novel bio-based resin for DLP 3D printing using photocurable polyester obtained from renewable resources. The ink is formulated with phosphorescent Ir-complexes and printed both rigid flexible structures.
Detection and removal of bladder cancer lesions at an early stage is crucial for preventing tumor relapse progression. This study aimed to develop a new technological platform the visualization small flat urothelial high-grade carcinoma in situ (CIS). We found that integrin α5β1, overexpressed cell lines, murine orthotopic human CIS, can be exploited as receptor targeted delivery GNRs functionalized with cyclic CphgisoDGRG peptide (Iso4). The GNRs@Chit-Iso4 was stable urine selectively...
Photopolymerization-based three-dimensional (3D) printing techniques, such as stereolithography (SLA), are becoming more popular due to their ability create complex geometries and material properties that difficult achieve with other methods. However, a major issue photopolymerization-based techniques is they rely on the use of harmful (meth)acrylic acid esters derived from fossil fuels. To address this, researchers have been exploring biobased alternatives itaconic acid, which building...
A simple method for the synthesis of lipophilic Ag NPs have been developed. The coated entrapped into a FDA-approved and targetable PEG-based polymeric nanoparticles, this nanocarrier has conjugated with peptide chlorotoxin. Uptake experiments shown cell-specific recognition Ag-1-PNPs-Cltx on U87MG cell lines in comparison to Balb/3T3. uptake cells was quantified an interesting cytotoxic effect (IC50 = 45 μM) found glioblastoma lines.
A Brønsted acid ionic liquid used as a solvent and catalyst allows easy mild esterification of nanocellulose with chlorotoxin peptide.