A5067197537- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Advanced biosensing and bioanalysis techniques
- 3D Printing in Biomedical Research
- Photoacoustic and Ultrasonic Imaging
- RNA Interference and Gene Delivery
- Electrospun Nanofibers in Biomedical Applications
- Bladder and Urothelial Cancer Treatments
- Bone Tissue Engineering Materials
- Lipid Membrane Structure and Behavior
- Electrohydrodynamics and Fluid Dynamics
- Ion-surface interactions and analysis
- Extracellular vesicles in disease
- Force Microscopy Techniques and Applications
- Advanced Cellulose Research Studies
- Cellular Mechanics and Interactions
- Hydrogels: synthesis, properties, applications
- Laser Material Processing Techniques
- Silk-based biomaterials and applications
- Neuroscience and Neural Engineering
- Infant Nutrition and Health
- Effects and risks of endocrine disrupting chemicals
- Sleep and related disorders
- Advanced Memory and Neural Computing
- Polymer Surface Interaction Studies
University of Bologna
2020-2025
Institute for Experimental Endocrinology and Oncology
2021-2022
National Research Council
2022
Weatherford College
2021
Ono Pharmaceutical (Japan)
2020
Institute of Organic Synthesis and Photoreactivity
2016-2019
Institute of Nanostructured Materials
2012-2016
Universidad Autónoma de Madrid
2013
Abstract Background Management of triple-negative breast cancer (TNBC) is still challenging because its aggressive clinical behavior and limited targeted treatment options. Cisplatin represents a promising chemotherapeutic compound in neoadjuvant approaches the metastatic setting, but use by scarce bioavailability, severe systemic side effects drug resistance. Novel site-directed aptamer-based nanotherapeutics have potential to overcome obstacles chemotherapy. In this study we investigated...
Small interfering RNA (siRNA) therapies require effective delivery vehicles capable of carrying the siRNA cargo into target cells. To achieve tumor-targeting, a drug system would have to incorporate ligands that specifically bind receptors expressed on cancer cells function as portals via receptor-mediated endocytosis. Cell-targeting and internalizing aptamers are most suitable for functionalization drug-loaded nanocarriers. Here, we designed novel aptamer-based platform active targeting...
Glioblastoma multiforme (GBM) is the most aggressive primary tumor of central nervous system and diagnosis often dismal. GBM pharmacological treatment strongly limited by its intracranial location beyond blood-brain barrier (BBB). While Temozolomide (TMZ) exhibits best clinical performance, still less than 20% crosses BBB, therefore requiring administration very high doses with resulting unnecessary systemic side effects. Here, we aimed at designing new negative temperature-responsive gel...
This work presents a novel bio-based resin for DLP 3D printing using photocurable polyester obtained from renewable resources. The ink is formulated with phosphorescent Ir-complexes and printed both rigid flexible structures.
Detection and removal of bladder cancer lesions at an early stage is crucial for preventing tumor relapse progression. This study aimed to develop a new technological platform the visualization small flat urothelial high-grade carcinoma in situ (CIS). We found that integrin α5β1, overexpressed cell lines, murine orthotopic human CIS, can be exploited as receptor targeted delivery GNRs functionalized with cyclic CphgisoDGRG peptide (Iso4). The GNRs@Chit-Iso4 was stable urine selectively...
Residual nonvisible bladder cancer after proper treatment caused by technological and therapeutic limitations is responsible for tumor relapse progression. This study aimed to demonstrate the feasibility of a solution simultaneous detection lesions smaller than one millimeter. The α5β1 integrin was identified as specific marker in 81% human high-grade nonmuscle invasive cancers used target delivery targeted gold nanorods (GNRs). In preclinical model orthotopic expressing integrin,...
Abstract The limitations of current diagnostic imaging techniques and therapies for bladder cancer are associated with responsible the recurrence progression residual disease, an impact on social costs quality life patients. This study delivers a cost‐effective solution detection which is represented by early lesions < 1 mm. Urine‐stable 34‐mer SH‐terminated 2′F‐Py‐RNA aptamer that recognizes integrin α5β1, expressed 81% human high‐grade non‐muscle invasive cancer, developed. intravesical...
Hybrid hydrogels made of chemically modified pectin, gelatin and xanthan gum have been formulated processed through a double crosslinking step, aimed at wound healing applications.
Photothermal therapy has always been a very attractive anti-cancer strategy, drawing lot of attention thanks to its excellent performance as non-invasive and pretty safe technique. Lately, nanostructures have become the main characters play cancer due their ability absorb near-infrared radiation efficient light-to-heat conversion. Here we present synthesis polyethylene glycol (PEG)-stabilized hybrid ultrasmall (<20 nm) gold–silver nanotriangles (AuAgNTrs) application in photothermal...
The interactions of a biodegradable scaffold with cells or living tissues depend on the time-evolution nanoscale properties scaffold. We present an in situ quantitative study early-stage swelling and degradation poly(lactic-co-glycolic acid) (PLGA). A novel metrology scheme based force microscopy measurements patterns PLGA nanostructures is developed to characterize evolution topography, volume nanomechanical properties. roughness show oscillating behaviour during first eight days immersion;...
The perifornical area in the posterior lateral hypothalamus (PeFLH) has been implicated several physiological functions including sleep-wakefulness regulation. PeFLH contains cell types those expressing orexins (Orx; also known as hypocretins), mainly located PeF nucleus. aim of present study was to elucidate synaptic interactions between Orx neurons and different brainstem involved generation wakefulness sleep stages such locus coeruleus (LC) nucleus (contributing wakefulness) oral pontine...
The natural peptide somatostatin has hormonal and cytostatic effects exerted by the binding to specific receptors in various tissues. Therapeutic uses are strongly prevented its very short biological half-life of 1-2 min due enzymatic hydrolysis, therefore encapsulation methodologies explored overcome need for continuous infusion regimes. Multilamellar liposomes made phosphatidylcholine were used incorporation a mixture sorbitol dissolved citrate buffer at pH = 5. Lyophilization...
It is well known that amphiphilic cationic β-cyclodextrins (amβCDs) form nanovesicles able to release their cargo in aqueous solution upon applying different stimuli. In addition they can be selectively positioned onto substrates by unconventional soft lithography. This makes them a powerful tool for designing environments where cues externally supplied the cells helping achieve good control of fate. Lithographically controlled wetting (LCW) amβCD loaded with fluorescein isothiocyanate...
Efficient conjugation of the MMP1-decoy to GNRs for imaging fibrillar collagen in NIR-I.
Abstract Background: Management of triple-negative breast cancer (TNBC) is still challenging because its aggressive clinical behavior and limited targeted treatment options. Cisplatin represents a promising chemotherapeutic compound in neoadjuvant approaches the metastatic setting, but use by scarce bioavailability, severe systemic side effects drug resistance. Novel site-directed aptamer-based nanotherapeutics have potential to overcome obstacles chemotherapy. In this study we investigated...