A5031123994- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Respiratory Support and Mechanisms
- SARS-CoV-2 and COVID-19 Research
- Nutrition and Health in Aging
- Hemodynamic Monitoring and Therapy
- COVID-19 and healthcare impacts
- Thermal Regulation in Medicine
- Sepsis Diagnosis and Treatment
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Advanced Causal Inference Techniques
- Renal and Vascular Pathologies
- Health Systems, Economic Evaluations, Quality of Life
- Renal Transplantation Outcomes and Treatments
- Organ Transplantation Techniques and Outcomes
- COVID-19 and Mental Health
- Vaccine Coverage and Hesitancy
- Nutritional Studies and Diet
- Liver Disease Diagnosis and Treatment
- Pneumothorax, Barotrauma, Emphysema
- Pharmaceutical Practices and Patient Outcomes
- Electrolyte and hormonal disorders
- Blood Pressure and Hypertension Studies
- Cardiac Health and Mental Health
- Frailty in Older Adults
Utrecht University
2023-2025
Universidad Nacional Autónoma de México
2020-2024
Autonomous University of Sinaloa
2024
Instituto Nacional de Cardiología
2020-2022
Autonomous University of Tlaxcala
2022
Instituto Nacional de Pediatria
2022
Red de Investigación Cardiovascular
2022
Instituto Nacional de Enfermedades Respiratorias
2020-2021
Instituto Nacional de Cardiologia
2021
sarcopenia is a disease associated with muscle changes during aging, and its detection remains challenge outside specialized clinical units. to evaluate the utility of Mini-Nutritional Assessment (MNA) in detecting institutionalized older persons. we conducted cross-sectional study adults aged 55 from Puebla. We administered both short form (SF) complete (LF) MNA. diagnosed according EWGSOP2 criteria. plotted points obtained MNA-SF MNA on ROC curve. evaluated odds ratio (OR) for presenting...
The awake prone positioning strategy for patients with acute respiratory distress syndrome is a safe, simple and cost-effective technique used to improve hypoxaemia. We aimed evaluate intubation mortality risk in coronavirus disease 2019 (COVID-19) who underwent during hospitalisation.In this retrospective, multicentre observational study conducted between 1 May 2020 12 June 27 hospitals Mexico Ecuador, nonintubated COVID-19 managed or supine were included through logistic regression models;...
Abstract Background The impact of the coronavirus disease 2019 (COVID-19) pandemic in Mexico City has been sharp, as several social inequalities at all levels coexist. Here we conducted an in-depth evaluation individual and municipal-level on COVID-19 City. Methods We analyzed suspected severe acute respiratory syndrome 2 (SARS-CoV-2) cases, from Epidemiological Surveillance System 24 February 2020 to 31 March 2021. outcomes included rates hospitalization, COVID-19, invasive mechanical...
Abstract Conflicting results have been obtained through meta-analyses for the role of obesity as a risk factor adverse outcomes in patients with coronavirus disease-2019 (COVID-19), possibly due to inclusion predominantly multimorbid severe COVID-19. Here, we aimed study alone or combination other comorbidities short-term all-cause mortality and Mexican evaluated suspected COVID-19 ambulatory units hospitals Mexico. We performed retrospective observational analysis national cohort 71 103...
Vaccination has been effective in ameliorating the impact of COVID-19. Here, we report vaccine effectiveness (VE) nationally available COVID-19 vaccines Mexico.
Abstract Most of the existing prediction models for COVID-19 lack validation, are inadequately reported or at high risk bias, a reason which has led to discourage their use. Few have potential be extensively used by healthcare providers in low-resource settings since many require laboratory and imaging predictors. Therefore, we sought develop validate multivariable model death Mexican patients with COVID-19, using demographic patient history We conducted national retrospective cohort study...
Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent influenced by dietary factors. While high sugar and fat consumption are associated with weight gain, their specific impact on accumulation remains unclear. This study aimed to evaluate the relationship between saturated intake body composition. Methods: A cross-sectional was conducted from September 2021 February 2023 in workers tertiary care center Mexico City. Anthropometric measurements,...
Domiciliary confinement of people is one the main strategies to limit impact COVID-19. Lockdowns have led changes in lifestyle, emotional health, and eating habits. We aimed evaluate association differences dietary behaviours lifestyle with self-reported weight gain during COVID-19 lockdown Chile. In this cross-sectional analytical study, five previously validated surveys were condensed into a single 86-item online questionnaire. The survey was sent 1000 potential participants university...
ABSTRACT The impact of the COVID-19 pandemic in Mexico City has been sharp, as several social inequalities coexist with chronic comorbidities. Here, we conducted an in-depth evaluation social, municipal, and individual factors on working-age population living City. To this end, used data from National Epidemiological Surveillance System; furthermore, a multidimensional metric, lag index (DISLI), to evaluate its interaction mean urban density (MUPD) rates. Influence DISLI MUPD effect...
Abstract Background Pulmonary atelectasis is present even before surgery in patients with obesity. No study has reported the prevalence of preoperative obese to date. We aimed estimate and extension obesity undergoing bariatric determine if variation SpO2 values seated position at room air explained by extent coverage supine position. Methods Cross-sectional a single center specialized laparoscopic surgery. Preoperative chest computed tomographies were reassessed senior radiologist quantify...
Background: The two-gasometry indirect Fick method (iFM) is commonly applied to estimate cardiac output (CO) and index (CI) in low-resource settings. Validation against other accessible methods such as transthoracic echocardiography (TTE) lacking. Objective: To determine agreement clinical interchangeability of CO CI measurements from TTE (reference test) iFM (index critical care patients a hospital. Methods: Cross-sectional study including patients. were measured by intensive medicine...
Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent influenced by dietary factors. While high sugar and fat consumption are associated with weight gain, their specific impact on accumulation remains unclear. This study aimed to evaluate the relationship between saturated intake body composition. Methods: A cross-sectional was conducted from September 2021 February 2023 in workers tertiary care center Mexico City. Anthropometric measurements,...
ABSTRACT Aim To evaluate all-cause mortality risk in patients with laboratory-confirmed COVID-19 Mexico City treated repurposed antivirals and antibiotics. Methods This real-world retrospective cohort study contemplated 395,343 evaluated for suspected between February 24 September 14, 2020 688 primary-to-tertiary medical units City. Patients were included a positive RT-PCR SARS-CoV-2; those receiving unspecified antivirals, excluded; prescribed <30 patients, eliminated. Survival risks...
The aim of our study was to evaluate all-cause mortality risk in patients with laboratory-confirmed COVID-19 Mexico City treated repurposed antivirals and antibiotics. This real-world retrospective cohort contemplated 395,343 evaluated for suspected between February 24 September 14, 2020 688 primary-to-tertiary medical units City. Patients were included a positive RT-PCR SARS-CoV-2; those receiving unspecified antivirals, excluded; groups prescribed < 30 patients, eliminated. Survival risks...
Recent studies suggest that the introduction of antiretroviral agents such as integrase strand transfer inhibitors (INSTI) may lead to weight gain in people living with HIV (PLHIV). In this retrospective observational study, we report changes observed virologically suppressed patients after 12 months switching bictegravir/emtricitabine/tenofovir alafenamide (BIC/F/TAF) due a national change public policy Mexico. Patients on prior regimens based TDF/FTC or ABC/3TC plus non-nucleoside...
Background: Most clinical trials are registered to be conducted in high-income countries (HIC), whereas low-to-middle income (LMIC) account for 32%. Building a non-HIC dependent trial research capacity LMIC is priority. However, certain ethical principles could jeopardized the process. Objective: To explore conditions ethically conduct independently from HIC. Material and Methods: Analysis ten Principles Benchmarks Ethical Clinical Research by Emanuel EJ, et al. A non-systematic search of...
Abstract We conducted a retrospective observational study in patients with laboratory-confirmed coronavirus disease (COVID-19) who received medical care 688 COVID-19 ambulatory units and hospitals Mexico City between 24 February 2020 December 2020, to if the elderly seek later than younger their severity of symptoms at initial evaluation. Patients were categorised into eight groups (<20, 20–29, 30–39, 40–49, 50–59, 60–69, 70–79 ≥80 years). Symptoms evaluation classified according...
ABSTRACT Purpose The awake prone position (PP) strategy for patients with acute respiratory distress syndrome (ARDS) is a safe, simple, and cost-effective technique used to improve hypoxemia. We aimed evaluate the relationship between PP (AP) endotracheal intubation in coronavirus disease (COVID-19). Methods In this retrospective, multicentre observational study conducted 1 May 12 June 2020 27 hospitals Mexico Ecuador, non-intubated COVID-19 managed AP or supine positioning (AS) were...
The pandemic SARS coronavirus 2 utilizes efficient mechanisms to establish infection and evade the immune system. Established leads severe inflammation in susceptible patients, main hallmark of progression disease (COVID-19). Knowledge has expanded rapidly. As emerges as central pathophysiological feature COVID-19, elucidating how system, lungs gut communicate interact with microbial components ecological niches that conform human microbiome will shed light on are promoted. Studying COVID-19...
ABSTRACT BACKGROUND Vaccination has been effective in ameliorating the impact of COVID-19. However, estimation vaccine effectiveness (VE) is still unavailable for some widely used vaccines and underrepresented groups. Here, we report on a nation-wide COVID-19 vaccination program Mexico. METHODS We test-negative design within national surveillance system to assess VE BNT162b2, mRNA-12732, Gam-COVID-Vac, Ad5-nCoV, Ad26.COV2.S, ChAdOx1 CoronaVac vaccines, against SARS-CoV-2 infection, related...
Pragmatic trials aim toassess intervention efficacy in real-world settings, contrasting with explanatory conducted controlled conditions. In aging research, pragmatic are important designs for the obtention of evidence elderly populations, often underrepresented trials. this review, we discuss statistical considerations from a frequentist approach to design and analysis Cluster randomization necessitates careful consideration sample size calculation methods, especially regarding missing data...
Pragmatic trials aim to assess intervention efficacy in usual patient care settings, contrasting with explanatory conducted under controlled conditions. In aging research, pragmatic are important designs for obtaining real-world evidence elderly populations, which often underrepresented trials. this review, we discuss statistical considerations from a frequentist approach the design and analysis of When choosing dependent variable, it is essential use an outcome that highly relevant medical...
Pragmatic trials aim to assess intervention efficacy in usual patient care settings, contrasting with explanatory conducted under controlled conditions. In aging research, pragmatic are important designs for obtaining real-world evidence elderly populations, which often underrepresented trials. this review, we discuss statistical considerations from a frequentist approach the design and analysis of When choosing dependent variable, it is essential use an outcome that highly relevant medical...
BACKGROUND: Pulmonary atelectasis is present even before surgery in patients with obesity. We aimed to estimate the prevalence and extension of preoperative obesity undergoing bariatric determine if variation Sp o 2 values seated position at room air explained by extent coverage supine position. METHODS: This was a cross-sectional study single center specialized laparoscopic surgery. Preoperative chest computed tomographies were reassessed senior radiologist quantify as percentage total lung...