A5050747712- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Botulinum Toxin and Related Neurological Disorders
- Balance, Gait, and Falls Prevention
- Genetic Neurodegenerative Diseases
- Alzheimer's disease research and treatments
- Dementia and Cognitive Impairment Research
- Stroke Rehabilitation and Recovery
- Nuclear Receptors and Signaling
- Motor Control and Adaptation
- Ginkgo biloba and Cashew Applications
- Neurological and metabolic disorders
- Muscle activation and electromyography studies
- Neurological diseases and metabolism
- Systemic Lupus Erythematosus Research
- Parkinson's Disease and Spinal Disorders
- EEG and Brain-Computer Interfaces
- Autism Spectrum Disorder Research
- Hereditary Neurological Disorders
- Lysosomal Storage Disorders Research
- Transcranial Magnetic Stimulation Studies
- Genetic Associations and Epidemiology
- Musculoskeletal pain and rehabilitation
- Cerebral Palsy and Movement Disorders
- RNA regulation and disease
Tel Aviv University
2015-2024
Weizmann Institute of Science
1995-2020
Sheba Medical Center
2009-2019
University of Applied Sciences Leiden
2018
European Union
2018
Ben-Gurion University of the Negev
2016
Hillel Yaffe Medical Center
1998-2009
Tel Aviv Sourasky Medical Center
1990-2009
Technion – Israel Institute of Technology
2000-2007
Meir Medical Center
2007
Transcranial magnetic stimulation has been used in a double pulse paradigm to investigate the excitability of intrinsic motor cortical circuits 15 patients with focal task specific dystonia right hand and group eight age matched controls. The left hemisphere was examined five patients; remainder, both hemispheres were tested. There no significant difference threshold between controls nor patients. decrease early corticocortical suppression when comparing at interstimulus intervals 1-15 ms (P...
Abstract Using the technique of transcranial magnetic stimulation over motor areas cortex and recording electromyographic (EMG) responses from first dorsal interosseous muscle, we measured excitability corticocortical inhibitory circuits at rest using a double pulse paradigm, in 11 patients with Parkinson's disease (PD) studied both on (ON) off (OFF) (after overnight withdrawal) their normal medication 10 age‐matched control subjects. There was significant decrease amount inhibition short...
Objectives: To determine whether genotypes at CLU, PICALM, and CR1 confer risk for Alzheimer disease (AD) AD associated with these genes is influenced by apolipoprotein E (APOE) genotypes.
Genetic loci for Alzheimer's disease (AD) have been identified in whites of European ancestry, but the genetic architecture AD among other populations is less understood.We conducted a transethnic genome-wide association study (GWAS) late-onset Stage 1 sample including Ancestry, African-Americans, Japanese, and Israeli-Arabs assembled by Disease Genetics Consortium. Suggestive results from novel were followed up using summarized International Genomics Project GWAS dataset.Genome-wide...
The aim of the present study was (i) to compare disease progression and survival in different types degenerative ataxia, (ii) identify variables that may modify rate progression. We included patients suffering from Friedreich's ataxia (FRDA, n = 83), early onset cerebellar (EOCA, 30), autosomal dominant (ADCA) type I (ADCA-I, 273), ADCA-III (n 13) multiple system atrophy (MSA, 67). Molecular genetic testing allowed us assign 202 ADCA-I one following subgroups: spinocerebellar (SCAI, 36),...
The study of gait at self-selected speed is important. Traditional laboratories being relatively limited in space provide insufficient path length, while treadmill (TM) walking compromises natural by imposing variables. Self-paced (SP) can be realized on TM using feedback-controlled belt speed. We compared over ground vs. SP two experiments: without visual flow, and subjects were immersed a virtual reality (VR) environment inducing flow.Young healthy walked 96 meters comfortable speed, first...
Extensive research shows that virtual reality (VR) enhances motor learning and has advantages in balance gait rehabilitation of neurological patients. There is still uncertainty, however, as for the practicality efficacy VR long-term clinical routine. The objective this study was to report on 3 years practice conducting VR-based a large medical center.This retrospective systematically analyzed records patients who received center during years. We evaluated effect treatments gait, cognitive...
Whereas visual hallucinations are often found among patients with Parkinson's disease, the occurrence of auditory has never been systematically documented. The occurrence, past and present, studied in 121 consecutive disease attending a movement disorders clinic. cognitive state was evaluated using short mental test (SMT). Hallucinations were reported for 45 (37%); 35 (29%) had only 10 (8%) both hallucinations. No patient unaccompanied by occurred repeatedly, consisting human voices. They...
Rasagiline mesylate (TVP-1012) is a potent, selective, non-reversible MAO-B inhibitor, without the tyramine-potentiating effect and with neuroprotective activities. The benefit of rasagiline as monotherapy in patients early Parkinson's disease (PD) has already been reported. To evaluate safety, tolerability, clinical adjunctive therapy to levodopa, multicenter, double-blind, randomized, placebo-controlled, parallel-group study (0.5, 1, 2 mg/d) was conducted for 12 weeks 70 PD (mean age, 57.4...
The electroencephalograms (EEG) of patients with Parkinson's disease (PD) were evaluated in relation to age, mental status and motor disability. Abnormalities, particularly mild slowing, observed 34% 128 more frequently the elderly. While a slowing occipital background activity was frequent demented patients, statistically significant association also between degree disability frequency mentally intact patients. This correlation may suggest that subcortical structures (involved control)...
We screened LRRK2 mutations in exon 41 904 parkin-negative Parkinson's disease (PD) patients (868 probands) from 18 countries across 5 continents. found three heterozygous missense (novel I2012T, G2019S, and I2020T) 41. identified 11 (1.3%) among 868 PD probands, including 2 sporadic cases 8 (6.2%) of 130 autosomal dominant families. The exhibited relatively common worldwide distribution. Among the 41, it has been reported that Caucasian with G2019S mutation have a single-founder effect. In...
Patients with Parkinson disease (PD) who harbor LRRK2 G2019S mutations may have increased risks of nonskin cancers. However, the results been inconsistent across studies.To analyze pooled data from 5 centers to further examine association between mutation and cancer among patients PD explore factors that could explain discrepancies.Clinical, demographic, genotyping as well outcomes were 1549 recruited movement disorders clinics located in Europe, Israel, United States. Associations examined...
Objective Creative thinking requires a combination of originality, flexibility, and usefulness. Several reports described enhanced artistic creativity in Parkinson disease (PD) patients treated with dopaminergic agents. We aimed to examine PD patients' ability perform tasks compared healthy controls verify whether is related an impulse control disorder (ICD) as complication therapy. Methods Right‐handed dopamine agonists and/or levodopa, age‐ education‐ matched neurologically were assessed...
Midlife habits may be important for the later development of Alzheimer's disease (AD). We estimated contribution midlife prayer to cognitive decline. In a door-to-door survey, residents aged ≥65 years were systematically evaluated in Arabic including medical history, neurological, examination, and leisure-activities questionnaire. Praying was assessed by number monthly praying hours at midlife. Stepwise logistic regression models used evaluate effect on odds mild impairment (MCI) AD versus...
In view of the fact that cancer patterns in patients with Parkinson disease (PD) differ from general population, we aimed to verify whether PD LRRK2 mutations have an increased risk for particular types.In this cross-sectional study, eligible consenting Jewish were genotyped predominant G2019S mutation. Oncologic data obtained by personal interview and reviewing patients' files. Stepwise logistic regression was applied model probability occurrence carriers vs noncarriers.Overall, 79/490...
Freezing of gait (FoG) is a debilitating symptom advanced Parkinson's disease (PD) characterized by sudden, episodic stepping arrest despite the intention to continue walking. The etiology FoG still unknown, but accumulating evidence unraveled physiological signatures autonomic nervous system (ANS) around episodes. Here we aim investigate for first time whether detecting predisposition upcoming events from ANS activity measured at rest possible.We recorded heart-rate 1-min while standing in...
ABSTRACT: Background: Pulmonary and respiratory muscle function impairment are common in patients with Parkinson's disease (PD). Inspiratory training may improve strength, dyspnea functional capacity healthy subjects those chronic obstructive pulmonary disease. This study investigated the effect of specific inspiratory (SIMT) on functions, performance, quality life, PD. Patients Methods: Twenty PD (stage II III Hoehn Yahr scale) were recruited for divided into two groups: a) ten who received...