A5032080236- Autoimmune Neurological Disorders and Treatments
- CNS Lymphoma Diagnosis and Treatment
- Cerebral Venous Sinus Thrombosis
- Peripheral Neuropathies and Disorders
- Single-cell and spatial transcriptomics
- Immune cells in cancer
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer Immunotherapy and Biomarkers
- Food Security and Health in Diverse Populations
- Acute Lymphoblastic Leukemia research
- Cardiac Arrest and Resuscitation
- Prion Diseases and Protein Misfolding
- Gut microbiota and health
- Health and Lifestyle Studies
- Polyomavirus and related diseases
- Acute Ischemic Stroke Management
- Venous Thromboembolism Diagnosis and Management
- Autoimmune and Inflammatory Disorders Research
- Molecular Biology Techniques and Applications
- Neurosurgical Procedures and Complications
- Redox biology and oxidative stress
- Glycogen Storage Diseases and Myoclonus
- Traumatic Brain Injury Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Alcoholism and Thiamine Deficiency
Mayo Clinic
2023-2024
Mayo Clinic in Arizona
2023-2024
Mayo Clinic in Florida
2024
WinnMed
2024
Jacksonville College
2024
University of California, Davis
2021
Ragon Institute of MGH, MIT and Harvard
2019-2020
Massachusetts Institute of Technology
2018-2020
Harvard University
2019-2020
IIT@MIT
2019
Abstract Variability in bacterial sterilization is a key feature of Mycobacterium tuberculosis (Mtb) disease. In population human macrophages, there are macrophages that restrict Mtb growth and those do not. However, the sources heterogeneity macrophage state during infection poorly understood. Here, we perform RNAseq on restrictive permissive reveal expression genes involved GM-CSF signaling discriminates between two subpopulations. We demonstrate blocking makes more while addition...
Clinical tissues are prepared for histological analysis and long-term storage via formalin fixation paraffin embedding (FFPE). The FFPE process results in fragmentation chemical modification of RNA, rendering it less suitable by techniques that rely on reverse transcription (RT) such as RT-qPCR RNA-Seq. Here we describe a broadly applicable technique called 'Ligation situ Hybridization' ('LISH'), which is an alternative methodology the RNA. LISH utilizes T4 RNA Ligase 2 to efficiently join...
Abstract Interactions between pathogens and their hosts can induce complex changes in both host pathogen states to privilege survival or clearance of the pathogen. To determine consequences specific host–pathogen interactions, a variety techniques microbiology, cell biology, immunology are available researchers. Systems biology that enables unbiased measurements transcriptomes, proteomes, other biomolecules has become increasingly common study interactions. These approaches be used generate...
A 75-year-old male presented with episodes of bilateral lower extremity weakness and back pain.Examination demonstrated intact strength spasticity the extremities.While right patellar reflex exhibited an extension response clonus, left leg knee flexion (video).This inverted implicated L2-L4 segment/root dysfunction, leading to absence quadriceps response, alongside pathologic hyperreflexia triggering activation opposing hamstring. 1Together, these findings suggested a thoracic myelopathy...
Evaluation of rapidly progressive dementia (RPD) is usually challenging. In most cases, patients progress to in weeks months, and the differential diagnosis broad. this case, a woman her 60s presented with 1-month history episodic vertigo, cognitive decline, ataxia myoclonus. Cerebrospinal fluid total tau was markedly elevated, which helpful establishing discussing prognosis/end-of-life measures patient’s family. This case summarises stepwise diagnostic approach for RPD highlights recent...
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Cooking programs are one avenue to promote healthy eating. However, many cooking a size-fits-all approach and do not consider costs, time, accessibility, or cultural barriers the recipes being taught. Healthy Bites is program developed by medical students, physician assistant chefs remedy this redesigning be less than $3 per meal, fewer 30 minutes cook, inclusive of accessible ingredients, tailored for Latin American dishes. In descriptive work, we implemented (HB) recruiting Latino...
Abstract Macrophages are central mediators of immunity that integrate diverse signals derived from differentiation cues, tissue location, and disease. Controlling macrophage state function is an appealing therapeutic objective across many diseases including cancer, atherosclerosis, tuberculosis. Despite the growing appreciation for in vivo complexity state, existing vitro models human monocyte-derived macrophages have used a limited number individual perturbations to explore complex...
Progressive multifocal leucoencephalopathy (PML) is a demyelinating white matter disease that most often affects immunocompromised people infected by JC virus. The diagnostic gold standard demonstrable viral DNA or protein from histopathological tissue. However, there are few detailed descriptions of cortical grey involvement on neuroimaging. Here we describe the correlate cerebral and radiological accompaniment in patient with biopsy proven PML.