A5028362639- Synthesis and bioactivity of alkaloids
- Synthesis and pharmacology of benzodiazepine derivatives
- Synthesis and Reactivity of Heterocycles
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Synthesis and Biological Evaluation
- Chemical synthesis and alkaloids
- Nicotinic Acetylcholine Receptors Study
- Natural product bioactivities and synthesis
- Synthesis and Characterization of Pyrroles
- Synthesis and Reactions of Organic Compounds
- Neurological Disorders and Treatments
- Synthesis and Characterization of Heterocyclic Compounds
- Phytochemistry and Biological Activities
- Cholinesterase and Neurodegenerative Diseases
- Synthesis and biological activity
- Essential Oils and Antimicrobial Activity
KazMunayGas (Kazakhstan)
2019-2022
BACKGROUND: The low solubility of pinostrobin in water limits its use, causing technological difficulties and significantly reducing bioavailability. "solid dispersion method" can increase both the release a number active substances from various dosage forms. AIM: purpose this study is pharmacological solid based on it. MATERIAL AND METHODS: Experiments were performed vitro vivo cells human hepatocellular carcinoma (HepG2) 90 white outbred male female rats 24 mice. Methods used to assess...
The genus Achillea L. is represented by 10 species in the flora of Kazakhstan, among them tianschanica Kupr.et Kulemin endemic.The report presents results a chemical study Kulemin, collected flowering phase Sairam-Ugam National Park along theslope and floodplain Sairamsu River Turkestan Region Republic Kazakhstan.For comparative analysis composition essential oil extractives A.tianschanica related species: A. nobilis L., A.millefolium setacea Waldst.et Kit.and stricta we carried out...
The present paper deals with chemical synthesis based on 8-acetylharmine. It was established thatinteraction of 8-acetylharmine hydrazine hydrate produces (E)-8-(1-hydrazonoethyl)-7-methoxy-1-methyl-9Hpyrido[3,4-b]indole in a yield 69%. shown, that reaction (E)-8-(1-hydrazonoethyl)-7-methoxy-1-methyl9H-pyrido[3,4-b]indole functionally substituted aromatic aldehydes (anisaldehyde, 2-fluorobenzaldehyde,2,4- dimethoxybenzaldehyde) by boiling methanol leads to the formation corresponding...
Natural alkaloids are promising compounds for the development of new domestic neurotropic drugs based on them. The article presents results a study effect plant (harmine, delphinifolin, echinopsin, zongoramine). assessment samples was carried out model experimental stress using tests «Open field» and «Raised cross-shaped maze».. As result conducted studies, it found that harmine, echinopsin zongoramin at dose 10 mg / kg exhibit effect, increasing level research activity, reducing anxiety,...