A5053323937- Sesquiterpenes and Asteraceae Studies
- Natural product bioactivities and synthesis
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Phytochemistry and Biological Activities
- Essential Oils and Antimicrobial Activity
- Plant Toxicity and Pharmacological Properties
- Plant chemical constituents analysis
- Crystallography and molecular interactions
- Synthesis and biological activity
- Medicinal plant effects and applications
- Allelopathy and phytotoxic interactions
- Plant Ecology and Taxonomy Studies
- Bee Products Chemical Analysis
- Plant biochemistry and biosynthesis
- Click Chemistry and Applications
- Fungal Biology and Applications
- Veterinary Equine Medical Research
- Flavonoids in Medical Research
- Natural Compound Pharmacology Studies
- Synthesis and Biological Evaluation
- Phytochemicals and Antioxidant Activities
Karaganda Medical University
2025
KazMunayGas (Kazakhstan)
2024
Despite the discovery of many chemotherapeutic drugs that prevent uncontrolled cell division processes, development compounds with higher anticancer efficacy and a lower level side effects is an important task in modern pharmaceutical chemistry. Herein, mild convenient method for preparation N1-substituted 3-(1,2,3-triazolyl-methoxycarbonyl)coumarins or bis(coumarine-3-carboxylate)bis(triazole)alkandiyl by copper(I)-catalyzed Huisgen cycloaddition reaction readily available...
BACKGROUND: The low solubility of pinostrobin in water limits its use, causing technological difficulties and significantly reducing bioavailability. "solid dispersion method" can increase both the release a number active substances from various dosage forms. AIM: purpose this study is pharmacological solid based on it. MATERIAL AND METHODS: Experiments were performed vitro vivo cells human hepatocellular carcinoma (HepG2) 90 white outbred male female rats 24 mice. Methods used to assess...
A variety of natural compounds have been shown to modulate T cell receptor (TCR) activation, including sesquiterpene lactones (SLs). In the present studies, we evaluated biological activity 11 novel semi-synthetic SLs determine their ability TCR activation. Of these compounds, α -epoxyarglabin, cytisinyl epoxyarglabin, 1 β ,10 -epoxyargolide, and chloroacetate grosheimin inhibited anti-CD3-induced Ca2+ mobilization extracellular signal-regulated kinase 1/2 (ERK1/2) phosphorylation in Jurkat...
The article provides an overview of phytopreparations technology based on essential oils, in particular: criteria for the selection components, qualitative and quantitative compositions analyzes, parameters technological cycle production drugs, problems standardization quality control stages original drugs. A number standard samples terpenoids phased medicinal products are described, which included European, Kazakhstan Japanese pharmacopeias. main countries producing oils their as well...
В статье приведены литературные данные по актуальным проблемам здравоохранения, касающиеся инфекций, вызванные бактериями с лекарственной устойчивостью, что приводит к использованию существующих антибиотиков клинически неэффективным. Поэтому разработка новых лекарственных средств на основе кумаринов новыми структурами и механизмами действия является направлением, которые позволят предотвратить распространения бактерий тем самым сократить продолжительность терапии. связи полифункциональностью...
The development of a dental gel that meets modern requirements for the effectiveness and safety medicinal product is serious scientific study related to selection active auxiliary substances, providing necessary biopharmaceutical rheological properties composition, standardizing quality dosage form. article presents results on composition technology soft form new «Matripin- Dent» using pharmacologically ingredients sum flavonoids from Populus balsamifera L. buds (pinostrobin, pinocembrin,...