A5102011593- Birth, Development, and Health
- Folate and B Vitamins Research
- Regulation of Appetite and Obesity
- Pregnancy and preeclampsia studies
- Diet and metabolism studies
- Gestational Diabetes Research and Management
- Prenatal Screening and Diagnostics
- Obesity and Health Practices
- Metabolism and Genetic Disorders
- Nutrition, Genetics, and Disease
- Cannabis and Cannabinoid Research
- Infant Nutrition and Health
- Diet, Metabolism, and Disease
- Diabetes Management and Education
- Congenital Anomalies and Fetal Surgery
- Alcohol Consumption and Health Effects
- Assisted Reproductive Technology and Twin Pregnancy
HKU-Pasteur Research Pole
2024
University of Hong Kong
2024
Canada Research Chairs
2020
University of Toronto
1999-2020
Faculty (United Kingdom)
2020
Toronto Public Health
2020
North York General Hospital
1999
The purpose of this study was to identify risk factors for fetal loss and other pregnancy complications associated with genetic amniocentesis. Data were acquired in the Canadian Early Amniocentesis Trial (CEMAT), a multicentred (12) prospective, randomized trial comparing continuous ultrasound-guided early amniocentesis (EA) mid-trimester (MA) (CEMAT Group, 1998). Details procedure recorded analysed by allocation (EA versus MA), operator centre, correlated outcome. A total 62 spontaneous...
Background: Folic acid plays an important role in early brain development of offspring, including proliferation and differentiation neural stem cells known to impact the function food intake regulatory pathways. Excess (10-fold) intakes folic gestational diet have been linked increased obesity male rat offspring post-weaning.Objective: The present study examined effects content diets on two hypothalamic neuronal populations, neuropeptide Y (NPY) pro-opiomelanocortin (POMC), within pathways...
Abstract Scope: High‐folic‐acid diets during pregnancy result in obesity the offspring, associated with altered DNA‐methylation of hypothalamic food intake neurons. Like folic acid, methyl‐donor choline modulates foetal brain development, but its long‐term programing effects on energy regulation remain undefined. This study aims to describe effect offspring phenotype and energy‐regulatory mechanisms. Methods results: Wistar rat dams are fed an AIN‐93G diet recommended (RC, 1 g kg −1 diet),...
α-Linolenoylethanolamide and linoleoylethanolamide suppress short-term food intake in rats.
The prenatal period is a critical time of brain development. Maternal choline intake associated with improvement in memory and cognitive function the offspring. However, role regulation physiological functions controlled by hypothalamus has not been reported. objective this study to elucidate effects on utero programming hypothalamic energy regulatory neurons male Wistar rat Pregnant rats received an AIN-93G diet containing recommended (RC, 1 g/kg diet), low (LC, 0.5-fold), or high (HC,...
Intake recommendations for folic acid (FA, synthetic form of folate) are often exceeded by 2.5–7‐fold in North America, raising concern its potential adverse effects on maternal and child health. In Wistar rats, high (10×) but non‐toxic FA intakes during pregnancy lead to obesity, insulin resistance dysregulation central peripheral energy metabolism‐related genes both offspring dams later‐in‐life. Moreover, fed rat post‐weaning was reported induce inhibitory hepatic methyl‐metabolism,...
Diet during pregnancy programs the mother and offspring post-weaning (PW). Folic acid (FA, synthetic folate) mediates DNA methylation (DNAm) reactions high intakes, simulating those consumed by American women, lead to epigenetic dysregulation of energy metabolic pathways. 5-methyltetrahydrofolate (5MTHF), bioactive folate form, has gained popularity as a supplement due direct cellular uptake utilization does not increase unmetabolized FA (UMFA). However, comparison forms on in utero...
High gestational folic acid (FA) induces an obesogenic phenotype in male Wistar rat offspring. Imbalances between FA and other methyl-nutrients (i.e., choline) leading to perturbations the 1-carbon cycle may account for effects of high diets. Canadian women consume (2–7-fold) intakes FA, but most are not meeting recommended adequate choline. Choline is also absent from prenatal supplements. The objective this study evaluate interaction choline maternal diets rats on cycle, programming food...
Nutrition during pregnancy alters the "re-set" of maternal metabolism and in turn mother's metabolic phenotype later life. Folic acid (FA, synthetic folate) consumed at intakes above requirements by rats leads to increased weight gain altered DNA methylation central peripheral pathways regulating food intake. The objectives this study were examine effects below FA dietary on re-set energy Wistar rat mothers early post-birth. Pregnant (n = 12/group) fed an AIN93G diet with 5 levels FA: 0X, 1X...