A5089445997- Neonatal Respiratory Health Research
- Liver Disease Diagnosis and Treatment
- Immune Response and Inflammation
- Gout, Hyperuricemia, Uric Acid
- Drug Transport and Resistance Mechanisms
- Respiratory Support and Mechanisms
- Alcohol Consumption and Health Effects
- Pediatric health and respiratory diseases
- Liver Disease and Transplantation
- CAR-T cell therapy research
- Advanced Glycation End Products research
- Peroxisome Proliferator-Activated Receptors
- Pediatric Hepatobiliary Diseases and Treatments
- Asthma and respiratory diseases
- Pharmacological Effects and Toxicity Studies
- Diet, Metabolism, and Disease
- COVID-19 Clinical Research Studies
- Immunotherapy and Immune Responses
- Case Reports on Hematomas
- SARS-CoV-2 and COVID-19 Research
- Folate and B Vitamins Research
- Cancer Immunotherapy and Biomarkers
- Neurological Disease Mechanisms and Treatments
- Long-Term Effects of COVID-19
- Natural Antidiabetic Agents Studies
University of Hradec Králové
2021-2023
Charles University
2021-2023
Gamma Medica (United States)
2023
Comenius University Bratislava
2017-2020
Masaryk University
2016
Alveolar epithelial type II (ATII) cells and their proper function are essential for maintaining lung integrity homeostasis. However, they can be damaged by lipopolysaccharide (LPS) during Gram-negative bacterial infection. Thus, this study evaluated compared the effects of LPS on short long-term cultures A549 determining cell viability, levels oxidative stress antimicrobial peptide cathelicidin LL-37 changes in expression surfactant proteins (SPs). Moreover, we response to presence...
Bile acids (BA) play a significant role in the pathophysiology of nonalcoholic steatohepatitis (NASH). The present study evaluates modulation bile acid metabolomics by atorvastatin, cholesterol-lowering agent commonly used to treat cardiovascular complications accompanying NASH. NASH was induced mice 24 weeks consuming high–saturated fat, high-fructose, and high-cholesterol diet (F), with atorvastatin administered orally (20 mg/kg/day) during last three weeks. Biochemical histological...
Multidrug resistance-associated protein 2 (Mrp2) mediates biliary secretion of anionic endobiotics and xenobiotics. Genetic alteration Mrp2 leads to conjugated hyperbilirubinemia predisposes the development intrahepatic cholestasis pregnancy (ICP), characterized by increased plasma bile acids (BAs) due mechanisms that are incompletely understood. Therefore, this study aimed characterize BA metabolomics during experimental deficiency ICP. ICP was modeled ethinylestradiol (EE) administration...
Abstract Carvedilol is a widely used beta-adrenoreceptor antagonist for multiple cardiovascular indications; however, it may induce cholestasis in patients, but the mechanism this effect unclear. also prevents development of various forms experimental liver injury, its on nonalcoholic steatohepatitis (NASH) largely unknown. In study, we determined carvedilol (10 mg/kg/day p.o.) bile formation and acid (BA) turnover male C57BL/6 mice consuming either chow diet or western-type NASH-inducing...
The study aimed to prove the hypothesis that exogenous surfactant and an antibiotic polymyxin B (PxB) can more effectively reduce lipopolysaccharide (LPS)-induced acute lung injury (ALI) than treatment alone, evaluate effect of this on gene expression proteins (SPs). Anesthetized rats were intratracheally instilled with different doses LPS induce ALI. Animals 500 μg/kg have been treated (poractant alfa, Curosurf®, 50 mg PL/kg b.w.) or PxB 1% w.w. (PSUR + PxB) mechanically ventilated for 5...
Pulmonary surfactant has a relaxing effect on the airway smooth muscle (ASM), which suggests its role in pathogenesis of respiratory diseases associated with hyperreactivity ASM, such as asthma and chronic obstructive pulmonary disease (COPD). The ASM tone may be directly or indirectly modified by bacterial wall component lipopolysaccharide (LPS). This study elucidated LPS reactivity this interaction. experiments were performed using adult guinea pigs vitro method tissue organ bath (ASM...