A5076823200- Liver Disease Diagnosis and Treatment
- Drug Transport and Resistance Mechanisms
- Liver Disease and Transplantation
- Protein Kinase Regulation and GTPase Signaling
- Microbial Community Ecology and Physiology
- Diet, Metabolism, and Disease
- Hepatitis B Virus Studies
- Metabolism, Diabetes, and Cancer
- Lipid metabolism and disorders
- Eicosanoids and Hypertension Pharmacology
- Pediatric Hepatobiliary Diseases and Treatments
- Liver physiology and pathology
Charles University
2023-2025
Mayo Clinic
2023
WinnMed
2023
Mayo Clinic in Arizona
2020
Cholestatic liver diseases are characterized by intrahepatic accumulation of bile acids (BAs), exacerbating inflammation, and fibrosis. Dimethyl fumarate (DMF) is a clinically approved antiinflammatory drug that demonstrated protective effects in several experimental models injury. Still, its effect on BA homeostasis fibrosis has not been thoroughly studied. Herein, we hypothesized DMF could improve mitigate the progression cholestasis-induced The was administered to mice with...
Abstract Nonalcoholic fatty liver disease is the most common chronic and may progress to nonalcoholic steatohepatitis (NASH) hepatocellular carcinoma (HCC). The molecular determinants of this pathogenic progression, however, remain largely undefined. Since tumorigenesis driven by apoptosis, we examined effect overt hepatocyte apoptosis in a mouse model NASH using mice lacking myeloid cell leukemia 1 (Mcl1), pro-survival member BCL-2 protein family. Hepatocyte-specific Mcl1 knockout (Mcl1...
Abstract Carvedilol is a widely used beta-adrenoreceptor antagonist for multiple cardiovascular indications; however, it may induce cholestasis in patients, but the mechanism this effect unclear. also prevents development of various forms experimental liver injury, its on nonalcoholic steatohepatitis (NASH) largely unknown. In study, we determined carvedilol (10 mg/kg/day p.o.) bile formation and acid (BA) turnover male C57BL/6 mice consuming either chow diet or western-type NASH-inducing...
Background: NASH is the progressive form of NAFLD characterized by lipotoxicity, hepatocyte injury, tissue inflammation, and fibrosis. Previously, Rho-associated protein kinase (ROCK) 1 has been implicated in lipotoxic signaling hepatocytes vitro high-fat diet-induced lipogenesis vivo. However, whether ROCK1 plays a role liver inflammation fibrosis during unclear. Here, we hypothesized that pathogenic activation promotes murine pathogenesis. Methods Results: Patients with had increased...