A5055122791- Diet and metabolism studies
- Cholesterol and Lipid Metabolism
- Cancer, Lipids, and Metabolism
- Hormonal Regulation and Hypertension
- Nutrition and Health in Aging
- Lipoproteins and Cardiovascular Health
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Clinical Nutrition and Gastroenterology
- Inflammatory Biomarkers in Disease Prognosis
- Adipokines, Inflammation, and Metabolic Diseases
- Liver Disease Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Sepsis Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Pharmacology and Obesity Treatment
- Fatty Acid Research and Health
- Adipose Tissue and Metabolism
- Electrolyte and hormonal disorders
- Dialysis and Renal Disease Management
- Cancer, Hypoxia, and Metabolism
- Cardiovascular Disease and Adiposity
- Renal function and acid-base balance
- Drug Transport and Resistance Mechanisms
- Oral health in cancer treatment
- Gastric Cancer Management and Outcomes
Charles University
2013-2025
University Hospital Hradec Králové
2014-2025
University of Hradec Králové
2017-2022
Ocní klinika
2013
Abstract Background: Omentin-1 is an anti-inflammatory adipokine produced preferentially by visceral adipose tissue. Plasma levels of omentin-1 are decreased in obesity and other insulin-resistant states. Insulin resistance contributes to the changes cholesterol synthesis absorption as well. The aim this study was characterise plasma obese patients with diabetes mellitus type 1 during weight reduction, elucidate relationship between metabolism omentin-1. Methods: were measured diabetics ( n...
Background: Sulodexide is a glycosaminoglycan-based drug prescribed to patients with angiopathy. We performed pilot study investigate whether sulodexide positively modulates the endothelial glycocalyx (EG) layer and microcirculation in porcine model of EG enzymatic damage. The sugar-based lining that involved physiology capillary wall pathogenesis many diseases. Methods: damage was induced eight piglets by hyaluronidase III heparanase I given intravenously. Four animals received 600 IU...
<title>Abstract</title> <bold>Background/Objectives: </bold>Preoperative differentiation between responders and non-responders to ventriculoperitoneal (VP) shunting in the treatment of normal pressure hydrocephalus (NPH) remains a significant challenge. Identifying biomarkers presurgical assessment represents promising approach reducing need for invasive cerebrospinal fluid CSF testing. <bold>Methods</bold>: In this prospective observational study, thirty adult patients were classified into...
Abstract Preoperative differentiation between responders and non-responders to ventriculoperitoneal (VP) shunting in the treatment of normal pressure hydrocephalus (NPH) remains a significant challenge. Identifying biomarkers presurgical assessment represents promising approach reducing need for invasive cerebrospinal fluid CSF testing. In this prospective observational study, thirty adult patients were classified into Group A (responders VP shunting) B (non-responders) based on their...
Coronavirus disease (COVID-19) associated endotheliopathy and microvascular dysfunction are of concern.The objective the present single-center observational pilot study was to compare endothelial glycocalyx (EG) damage in patients with severe COVID-19 (COVID-19 group) bacterial pneumonia septic shock (non-COVID group).Biomarkers EG (syndecan-1), cells (EC) (thrombomodulin), activation (P-selectin) were measured blood on three consecutive days from admission intensive care unit (ICU). The...
In recent years, great attention has been given to the search for natural compounds or extracts with purpose of medical use. Evolvulus alsinoides L. (Convolvulaceae) is a plant used in traditional medicine East Asia many indications and known nootropic anti-inflammatory activity. However, bioactive constituents have described poorly literature. Four substances isolated from ethanol extract E. by means polyamide Silica-gel chromatography are reported here. Their molecular structures were...
The endothelial glycocalyx (EG) lining the endoluminal surface of capillaries has been proposed as a key component microcirculation and major player in microvascular pathology. Recent advances understanding its physiological role clinical significance have made upon development methods allowing EG assessment medicine. Laboratory can assess amount damage by measuring levels degradation products (e.g. syndecan-1, heparan sulphate hyaluronan sulphate), mostly plasma, however, their turnover...
Hydrogen is a potent antioxidant agent that can easily be administered by inhalation. The aim of the study was to evaluate whether hydrogen protects endothelial glycocalyx layer after successful cardiopulmonary resuscitation (CPR).Fourteen anesthetized pigs underwent CPR induced ventricular fibrillation. During and return spontaneous circulation, 2% gas seven (hydrogen group) constituted control group. Biochemistry sublingual microcirculation were assessed at baseline, during CPR, 15th,...
Bile acids (BA) play a significant role in the pathophysiology of nonalcoholic steatohepatitis (NASH). The present study evaluates modulation bile acid metabolomics by atorvastatin, cholesterol-lowering agent commonly used to treat cardiovascular complications accompanying NASH. NASH was induced mice 24 weeks consuming high–saturated fat, high-fructose, and high-cholesterol diet (F), with atorvastatin administered orally (20 mg/kg/day) during last three weeks. Biochemical histological...
Aims: We are currently witnessing changes in views on the evaluation of serum proteins. A decrease may signal not only malnutrition. It also be an indicator simultaneously occurring inflammatory disease. Prealbumin, due to its short half-life, is a suitable protein-energy balance, but levels show, as with other proteins, case inflammation too. The present study aimed determine prealbumin values hospitalized geriatric patients and how they affected by Methods: In 101 aged over 80 years,...