A5035624077- Antimicrobial Resistance in Staphylococcus
- Clostridium difficile and Clostridium perfringens research
- Streptococcal Infections and Treatments
- Bacterial biofilms and quorum sensing
- Antibiotic Resistance in Bacteria
- Infective Endocarditis Diagnosis and Management
- RNA and protein synthesis mechanisms
- Lipid Membrane Structure and Behavior
- Lysosomal Storage Disorders Research
- RNA regulation and disease
- Parkinson's Disease Mechanisms and Treatments
- Cellular transport and secretion
- RNA Research and Splicing
Microbiologie de l’alimentation au service de la santé
2020-2024
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2020-2024
AgroParisTech
2021-2024
Université Paris-Saclay
2021-2024
Université du Québec à Montréal
2023
Enterococcus faecalis , a normal and harmless colonizer of the human intestinal flora can cause severe infectious diseases in immunocompromised patients, particularly those that have been heavily treated with antibiotics. Therefore, it is important to understand factors promote its resistance virulence. E. which cannot synthesize heme, an essential but toxic metabolite, needs scavenge this molecule from host respire fight stress generated by oxidants.
Strict management of intracellular heme pools, which are both toxic and beneficial, is crucial for bacterial survival during infection. The human pathogen
ABSTRACT Synucleinopathies are characterized by the accumulation and propagation of α-synuclein (α-syn) aggregates throughout brain, leading to neuronal dysfunction death. Understanding how these propagate from cell in a prion-like fashion thus holds great therapeutic promises. Here, we focused on understanding cellular processes involved entry pathological α-syn aggregates. We used an unbiased FACS-based genome-wide CRISPR/Cas9 knockout (KO) screening identify genes that regulate preformed...
Abstract Alternative proteins (AltProts) represent a newly recognized class of biologically active encoded from alternative open reading frames (AltORFs) within already annotated genes. This study focuses on the SLC35A4 gene, which encodes both reference protein and AltSLC35A4. Using combination microscopy biochemical analyses, we confirmed presence AltSLC35A4 in inner mitochondrial membrane, resolving previous conflicting reports. Previous studies employing ribosome profiling have revealed...
Abstract Enterococcus faecalis is a commensal Gram-positive pathogen found in the intestines of mammals, and also leading cause severe infections occurring mainly among antibiotic-treated dysbiotic hospitalized patients. Like most intestinal bacteria, E. does not synthesize heme. Nevertheless, environmental heme can improve fitness by activating respiration metabolism catalase that limits hydrogen peroxide stress. Since free generates redox toxicity, its intracellular levels need to be...
Abstract Strict management of intracellular heme pools, which are both toxic and beneficial, can be crucial for bacterial survival during infection. The human pathogen Staphylococcus aureus uses a two-component sensing system (HssRS), counteracts environmental toxicity by triggering expression the efflux transporter HrtBA. HssS sensor is HisKA-type histidine kinase, characterized as membrane-bound homodimer containing an extracellular cytoplasmic conserved catalytic domain. To elucidate...