A5087626817- Biofuel production and bioconversion
- Microbial Metabolic Engineering and Bioproduction
- Enzyme Catalysis and Immobilization
- Monoclonal and Polyclonal Antibodies Research
- Enzyme Production and Characterization
- Glycosylation and Glycoproteins Research
- Biochemical and Structural Characterization
- Bacterial Genetics and Biotechnology
- RNA and protein synthesis mechanisms
- Viral Infectious Diseases and Gene Expression in Insects
- SARS-CoV-2 and COVID-19 Research
- Machine Learning in Bioinformatics
- Protein purification and stability
- Anaerobic Digestion and Biogas Production
- COVID-19 impact on air quality
- COVID-19 epidemiological studies
- Genomics and Phylogenetic Studies
- COVID-19 Clinical Research Studies
- Animal Virus Infections Studies
- Microbial Fuel Cells and Bioremediation
- Recycling and Waste Management Techniques
- Biochemical and biochemical processes
- Solidification and crystal growth phenomena
- CRISPR and Genetic Engineering
- Enzyme Structure and Function
South China University of Technology
2016-2025
Third Affiliated Hospital of Sun Yat-sen University
2025
Sun Yat-sen University
2025
China Electronics Technology Group Corporation
2024
University of South Carolina
2024
Temple University
2023
Shanghai Academy of Agricultural Sciences
2018-2022
Zhejiang University
2020-2021
Taiyuan University of Technology
2021
First Affiliated Hospital Zhejiang University
2021
The mouse-adapted strain of poliovirus type 2 (Lansing) induces fatal poliomyelitis in mice after intracerebral inoculation, whereas inoculated with 1 (Mahoney) show no signs disease. Previous work indicated that the adaptation to mouse virulence is associated viral capsid proteins and mutations neutralization antigenic site I reduce neurovirulence Lansing mice. role was further explored by constructing an hybrid virus. Six amino acids Mahoney were replaced a sequence specific for using...
Integrating waste management with fuels and chemical production is considered to address the food problem oil crisis. Approximately, 600 million tonnes crude glycerol produced from biodiesel industry annually, which a top renewable feedstock for succinic acid production. To meet increasing demand production, development of more efficient cost-effective methods urgently needed. Herein, we have proposed new strategy integration both SA in biorefinery unit by construction an aerobic yeast...
The GRAS and oleaginous yeast Yarrowia lipolytica (Y. lipolytica) is an attractive cell factory for the production of chemicals biofuels. many natural products commercial interest have been investigated in this by introducing heterologous biosynthetic pathways modifying endogenous pathways. However, since anabolism involves long complex regulation, re-channelling carbon into product target compounds still a cumbersome work, often resulting low performance.In carotenogenic genes contained...
The Plasmodium proteasome represents a potential antimalarial drug target for compounds with activity against multiple life cycle stages. We screened library of human inhibitors (peptidyl boronic acids) and compared activities purified P. falciparum 20S proteasomes. chose four hits that potently inhibit parasite growth show range selectivities inhibition the cell lines. was selected resistance in vitro to clinically used inhibitor, bortezomib, whole genome sequencing applied identify...
The mutations in the SARS-CoV-2 virus genome during COVID-19 dissemination are unclear. In 788 patients from Zhejiang province, we observed decreased rate of severe/critical cases compared with Wuhan. For mechanisms exploration, isolated one strain (ZJ01) a mild patient. Thirty-five specific gene were identified. Phylogenetic and relative synonymous codon usage analysis suggested that ZJ01 may be potential evolutionary branch SARS-CoV-2. We classified 54 global strains based on base (C or T)...
Succinate dehydrogenase inactivation in Yarrowia lipolytica has been demonstrated for robust succinic acid production, whereas the inefficient glucose metabolism hindered its practical application. In this study, a simple and efficient adaptive evolution strategy via cell immobilization was conducted shake flasks, with an aim to restore of Y. mutant PGC01003. After 21 days 14 generations evolution, consumption rate increased 0.30 g/L/h YPD medium consisting 150 g/L initial concentration,...
Hydrogen is regarded as an attractive future energy carrier for its high content and zero CO2 emission. Currently, the majority of hydrogen generated from fossil fuels. However, environmental perspective, sustainable production low-cost lignocellulosic biomass should be considered. Thermophilic attractive, since it can potentially convert a variety biomass-based substrates into at yields.Sugarcane bagasse (SCB) was used substrate by Thermoanaerobacterium aotearoense SCUT27/Δldh. The key...
Efficient conversion of lignocellulosic biomass to optically pure lactic acid is a key challenge for the economical production biodegradable poly-lactic acid. A recently isolated strain, Thermoanaerobacterium aotearoense SCUT27, promising as an efficient bacterium from due its broad substrate specificity. Additionally, strictly anaerobic and thermophilic characteristics suppress contamination other microoragnisms. Herein, we report significant improvements concentration yield in various...
Acid stress is often encountered during industrial fermentation as a result of the accumulation acidic metabolites. increases intracellular acidity and can cause DNA damage denaturation essential enzymes, thus leading to decrease growth yields. Although acid be relieved by addition base medium, fermentations with acid-tolerant strains are generally considered much more efficient cost-effective. In this study, global regulator H-NS was found have significant influence on tolerance E. coli....
Hydrogen is regarded as an attractive future energy carrier for its high content and zero CO2 emission. Currently, the majority of hydrogen generated from fossil fuels. However, environmental perspective, sustainable production low-cost lignocellulosic biomass should be considered. Thermophilic attractive, since it can potentially convert a variety biomass-based substrates into at yields. Sugarcane bagasse (SCB) was used substrate by Thermoanaerobacterium aotearoense SCUT27/Δldh. The key...
Curcumin (CUR) is a promising drug candidate based on its broad bioactivities and good antitumor effect, but the application of CUR potentially restricted because poor solubility bioavailability.This study aims at developing simple effective delivery system for to enhance bioavailability thus improve efficacy.Curcumin nanosuspensions (CUR-NSps) were prepared by precipitation-ultrasonication method using mPEG2000-DSPE soybean lecithin as combined stabilizer.CUR-NSps with high payload 67.07%...
Alkali used for pH control during fermentation and acidification downstream recovery of succinic acid (SA) are the two largest cost contributors bio-based SA production. To promote commercialization process fermentative SA, development industrially important microorganisms that can tolerate low has emerged as a crucial issue. In this study, an in situ fibrous bed bioreactor (isFBB) was employed metabolic evolution selection Y. lipolytica strain produce at using glucose-based medium. An...