A5073180534- Cardiac Structural Anomalies and Repair
- Trauma Management and Diagnosis
- Aortic Disease and Treatment Approaches
- RNA modifications and cancer
- Cardiac Arrhythmias and Treatments
- Angiogenesis and VEGF in Cancer
- Atrial Fibrillation Management and Outcomes
- Pleural and Pulmonary Diseases
- RNA and protein synthesis mechanisms
- interferon and immune responses
- HIV/AIDS drug development and treatment
- Cancer, Lipids, and Metabolism
- Ubiquitin and proteasome pathways
- Tendon Structure and Treatment
- Neuropeptides and Animal Physiology
- Innovations in Medical Education
- Cardiac Valve Diseases and Treatments
- Malaria Research and Control
- Interprofessional Education and Collaboration
- Intensive Care Unit Cognitive Disorders
- Receptor Mechanisms and Signaling
- Cardiac pacing and defibrillation studies
- Cancer Research and Treatments
- Fibroblast Growth Factor Research
- Cancer Cells and Metastasis
Hubei University of Medicine
2025
Kaohsiung Armed Forces General Hospital
2014-2024
National Sun Yat-sen University
2014-2024
Takeda (United States)
2010-2024
Tri-Service General Hospital
2008-2024
National Defense Medical Center
2008-2024
Kuang Tien General Hospital
2012-2021
Millennium Engineering and Integration (United States)
2010-2011
St. John's University
2004
Aminoacyl transfer RNA (tRNA) synthetases (aaRSs) are attractive drug targets, and we present class I II aaRSs as previously unrecognized targets for adenosine 5'-monophosphate-mimicking nucleoside sulfamates. The target enzyme catalyzes the formation of an inhibitory amino acid-sulfamate conjugate through a reaction-hijacking mechanism. We identified 5'-sulfamate broad-specificity compound that hijacks range ML901 specific reagent single aaRS in malaria parasite Plasmodium falciparum,...
The Plasmodium proteasome represents a potential antimalarial drug target for compounds with activity against multiple life cycle stages. We screened library of human inhibitors (peptidyl boronic acids) and compared activities purified P. falciparum 20S proteasomes. chose four hits that potently inhibit parasite growth show range selectivities inhibition the cell lines. was selected resistance in vitro to clinically used inhibitor, bortezomib, whole genome sequencing applied identify...
Hepatoma-derived growth factor (HDGF) participates in angiogenesis and represents a negative prognostic oral cancer. The current study was designed to elucidate the regulatory mechanism between HDGF vascular endothelial (VEGF) clinical impact of cancer.TCGA data surgical samples from cancer patients were used for clinicopathological parameter survival analysis. Human SCC4 SAS cells treated with recombinant protein. VEGF gene expression protein level analyzed by RT-PCR, Western blotting,...
Stimulator of Interferon Genes (STING) plays an important role in innate immunity by inducing type I interferon production upon infection with intracellular pathogens. STING activation can promote increased T-cell and inflammation the tumor microenvironment, resulting antitumor immunity. Natural synthetic cyclic dinucleotides (CDNs) are known to activate STING, several CDN molecules being investigated clinic using intratumoral administration route. Here, we describe identification agonist...
Significance Here, we describe inhibitors of the Plasmodium proteasome, an enzymatic complex that malaria parasites rely on to degrade proteins. Starting from developed treat cancer, derivatives were designed and synthesized with aim increasing potency against proteasome decreasing activity human enzyme. Biochemical cellular assays identified compounds exhibit selectivity potency, both in vitro vivo, at different stages parasite’s lifecycle. Cryo-electron microscopy revealed bind a...
Introduction: We hypothesized that hypertensive patients harbor a higher risk of urinary bladder (UB) cancer. Material and methods: performed population-based cohort study on adults using National Health Insurance Research Database (NHIRD) dataset. Hypertension comparison non-hypertensive (COMP) groups comprising 39,618 each were propensity score-matched by age, sex, index date, medical comorbidities. The outcome was incident UB cancer validated procedure codes. constructed multivariable Cox...
Abstract Epirubicin is a chemotherapy agent for hepatocellular carcinoma ( HCC ). However, the outcome of patients receiving epirubicin remains unsatisfactory. Moreover, our previous study indicated that celecoxib suppresses progression and liver cancer stemness. This evaluated potential to serve as complementary therapy during treatment. Cell proliferation, apoptosis, invasiveness, anchorage‐independent growth were analyzed in hepatoma cells. Therapeutic efficacy was validated rat...
Rationale: Severe pneumonia is a critical stage in the course of pneumonia, which accompanied by respiratory failure and obvious involvement other systems addition to common symptoms, with high mortality rate. This study summarizes nursing experience patient severe complicated multiple disorders under multidisciplinary team, aiming provide more comprehensive theoretical practical reference for patients disorders. Patient concerns: The patient, 43-year-old male, was admitted hospital due...
Inhibition of mutant B-Raf signaling, through either direct inhibition the enzyme or MEK, substrate Raf, has been demonstrated preclinically to inhibit tumor growth. Very recently, treatment melanoma patients with a selective inhibitor resulted in promising preliminary evidence antitumor activity. This article describes design and optimization tetrahydronaphthalene-derived compounds as potent inhibitors Raf pathway vitro vivo. These possess good pharmacokinetic properties rodents growth...
Autophagy is postulated to be required by cancer cells survive periods of metabolic and/or hypoxic stress. ATG7 the E1 enzyme that for activation Ubl conjugation pathways involved in autophagosome formation. This article describes design and optimization pyrazolopyrimidine sulfamate compounds as potent selective inhibitors ATG7. Cellular levels autophagy markers, LC3B NBR1, are regulated following treatment with these compounds.
This cohort study aimed to investigate the association between steroid injections for shoulder diseases and increased incidence of cuff tendon tears. The Kaohsiung Veterans General Hospital clinical database was used in this study. Patients were enrolled using corresponding diagnostic codes diseases. who received included case group, those without control group. outcome measure occurrence tears during period. Adjusted hazard ratios outcomes calculated Cox regression analysis adjusted sex,...
Sialylation of glycoproteins is modified by distinct sialyltransferases such as ST3Gal, ST6Gal, ST6GalNAc, or ST8SIA with α2,3-, α2,6-, α2,8-linkages. Alteration these causing aberrant sialylation associated the progression colon cancer. However, among ST8- sialyltransferases, role ST8SIA6 in cancer remains poorly understood. In this study, we explored involvement using multiple gene databases. The relationship between expression and tumor stages/grades was investigated UALCAN analysis,...
ABSTRACT Environmental antineoplastics such as sorafenib may pose a risk to humans through water recycling, and the increased of cardiotoxicity is clinical issue in users. Thus, developing strategies prevent an urgent work. Empagliflozin, sodium‐glucose co‐transporter‐2 (SGLT2) inhibitor for type 2 diabetes control, has been approved heart failure therapy. Still, its cardioprotective effect experimental model not yet reported. Real‐time quantitative RT‐PCR (qRT‐PCR), immunoblot,...
Background: WA-25 (dihydroaustrasulfone alcohol, a synthetic derivative of marine compound WE-2) suppresses atherosclerosis in rats by reducing neointima formation. Because angiogenesis plays critical role the pathogenesis atherosclerosis, present study investigated angiogenic function and mechanism WA-25. Methods: The effect was evaluated using rat aortic ring assay transgenic zebrafish models were established Tg(fli-1:EGFP)y1 Tg(kdrl:mCherryci5-fli1a:negfpy7) embryos. In addition, on...
α-melanocyte-stimulating hormone (α-MSH) has been characterized as a novel angiogenesis inhibitor. The homeostasis of nitric oxide (NO) plays an important role in neovascularization. However, it remains unclear whether α-MSH mitigates through modulation NO and its signaling pathway. present study elucidated the function mechanism α-MSH-induced inhibition using cultured human umbilical vein endothelial cells (HUVECs), rat aorta rings, transgenic zebrafish. By Griess reagent assay, was found...
Symmetrical peripheral gangrene is an uncommon but devastating complication in critically ill patients, and it has a high mortality. It seen wide variety of medical conditions, presenting as symmetrical two or more extremities without large blood vessel obstruction.We report case 44-year-old Chinese man who was diagnosed with alcohol-related severe acute pancreatitis presented systemic inflammatory response syndrome intractable vomiting. On the fourth day admission, patient developed...