A5026391773- Glycosylation and Glycoproteins Research
- Ferroptosis and cancer prognosis
- Cancer, Lipids, and Metabolism
- Cancer Research and Treatments
- Cancer Cells and Metastasis
- 3D Printing in Biomedical Research
- Galectins and Cancer Biology
- Stress Responses and Cortisol
- Ion Channels and Receptors
- Hemodynamic Monitoring and Therapy
- Peptidase Inhibition and Analysis
- Metabolomics and Mass Spectrometry Studies
- Physiological and biochemical adaptations
- vaccines and immunoinformatics approaches
- Tryptophan and brain disorders
- Liver physiology and pathology
- Cancer-related Molecular Pathways
- biodegradable polymer synthesis and properties
- Alzheimer's disease research and treatments
- Esophageal and GI Pathology
- Healthcare Technology and Patient Monitoring
- SARS-CoV-2 and COVID-19 Research
- Machine Learning in Bioinformatics
- Reproductive Physiology in Livestock
- Memory and Neural Mechanisms
National Sun Yat-sen University
2023-2025
Kaohsiung Armed Forces General Hospital
2022-2025
National Defense Medical Center
2025
Tri-Service General Hospital
2025
National Cheng Kung University
2013-2022
Colorectal cancer (CRC) is a leading cause of cancer-related deaths worldwide, characterized by high incidence and poor survival rates. Glycosylation, fundamental post-translational modification, influences protein stability, signaling, tumor progression, with aberrations implicated in immune evasion metastasis. This study investigates the role glycosylation-related genes (Glycosylation-RGs) CRC using machine learning bioinformatics. Data from The Cancer Genome Atlas (TCGA) Molecular...
Multidrug resistance (MDR), an unfavorable factor compromising the treatment efficacy of anticancer drugs, involves upregulation ATP binding cassette (ABC) transporters and induction galectin-3 signaling. Galectin-3 plays anti-apoptotic role in many cancer cells regulates various pathways to activate MDR. Thus, inhibition has potential enhance drug epirubicin. In this study, we examined effects mechanisms silencing via RNA interference (RNAi) on β-catenin/GSK-3β pathway human colon...
ABSTRACT Environmental antineoplastics such as sorafenib may pose a risk to humans through water recycling, and the increased of cardiotoxicity is clinical issue in users. Thus, developing strategies prevent an urgent work. Empagliflozin, sodium‐glucose co‐transporter‐2 (SGLT2) inhibitor for type 2 diabetes control, has been approved heart failure therapy. Still, its cardioprotective effect experimental model not yet reported. Real‐time quantitative RT‐PCR (qRT‐PCR), immunoblot,...
Colorectal cancer (CRC) is a leading cause of cancer-related deaths worldwide, charac-terized by high incidence and poor survival rates. Glycosylation, fundamental post-translational modification, influences protein stability, signaling, tumor pro-gression, with aberrations implicated in immune evasion metastasis. This study investigates the role glycosylation-related genes (Glycosylation-RGs) CRC using machine learning bioinformatics. Data from The Cancer Genome Atlas (TCGA) Molecular...
Background Nurses on the frontlines of pandemic have increased workloads, burnout, and virus exposure, leading to mental health challenges a lack resources for patient care. Mental support nurses during COVID-19 outbreak has become priority. This study evaluated psychological outcomes among 2022–2023 in Taiwan, focusing personal work-related fatigue as key contributors emotional distress.
Phthalates are widely used as plasticizers. Humans can be exposed to phthalates through ingestion, inhalation, or treatments that release di(2-ethylhexyl) phthalate (DEHP) and its metabolite, mono(2-ehylhexyl) (MEHP), into the body from polyvinyl chloride-based medical devices. Phthalate exposure may induce reproductive toxicity, liver damage, carcinogenesis in humans. This study found colon cancer cells DEHP MEHP exhibited increased cell viability levels of P-glycoprotein, CD133, Bcl-2,...
Sialylation of glycoproteins is modified by distinct sialyltransferases such as ST3Gal, ST6Gal, ST6GalNAc, or ST8SIA with α2,3-, α2,6-, α2,8-linkages. Alteration these causing aberrant sialylation associated the progression colon cancer. However, among ST8- sialyltransferases, role ST8SIA6 in cancer remains poorly understood. In this study, we explored involvement using multiple gene databases. The relationship between expression and tumor stages/grades was investigated UALCAN analysis,...
An outbreak of SARS-CoV-2 coronavirus (COVID-19) first detected in Wuhan, China, has created a public health emergency all over the world. The pandemic caused more than 340 million confirmed cases and 5.57 deaths as 23 January 2022. Although carbohydrates have been found to play role binding infection, cell surface glycans infection pathogenesis is still not understood. Herein, we report that spike protein S1 subunit binds specifically blood group A B antigens, S2 preference for Lea...
Leukocyte cell-derived chemotaxin 2 (LECT2) acts as a tumor suppressor in hepatocellular carcinoma (HCC). However, the antineoplastic mechanism of LECT2, especially its influence on hepatic cancer stem cells (CSCs), remains largely unknown. In The Cancer Genome Atlas cohort, LECT2 mRNA expression was shown to be associated with stage, grade, recurrence, and overall survival human HCC patients, downregulated hepatoma tissues compared adjacent nontumoral liver. Here, we show by...
Background and Objectives: Stem cell therapy shows great promise for treating Alzheimer's disease (AD). Cholinesterase inhibitors (ChEIs) like donepezil are well-established alleviating AD symptoms. This study aimed to determine if combining ChEI treatment with stem could improve therapeutic outcomes. Methods: Neural cells (NSCs) were injected into the hippocampus of 5xFAD mice using a stereotactic technique. Following this, or placebo was administered one month. We assessed behavioral...
Clear cell renal carcinoma (ccRCC) is the most common RCC subtype with a high mortality. It has been reported that delta-like 1 homologue (DLK1) participates in tumor microenvironmental remodeling of ccRCC, but relationship between 2 (DLK2, DLK1 homologue) and ccRCC still unclear. Thus, this study aims to investigate role DLK2 biological function disease prognosis using bioinformatics analysis. The TNMplot database showed was upregulated tissues. From UALCAN analysis, overexpression...
The clinical use of mifepristone for medical abortions has been established in 1987 France and since 2000 the United States. Mifepristone a limited period that lasts <9 weeks gestation, incidence treatment failure increases with gestation time. functions as an antagonist progesterone glucocorticoid receptors. Studies have confirmed treatments can directly contribute to endometrium disability by interfering endometrial receptivity embryo, thus causing decidual degeneration. However, whether...
BACKGROUND Self-injection locking (SIL) radar uses continuous-wave and an injection-locked oscillator-based frequency discriminator that receives demodulates signals remotely to monitor vital signs. This study aimed compare SIL with traditional electrocardiogram (ECG) measurements respiratory rate (RR) heartbeat (HR) during the COVID-19 pandemic at a single hospital in Taiwan. MATERIAL AND METHODS We recruited 31 staff members (16 males 15 females) for rates detection. Data acquisition ECG...
Temporal percutaneous transhepatic duodenum drainage (PTDD) seems to be effective in the treatment of postoperative afferent loop syndrome (ALS) following transverse colostomy for obstructive colorectal cancer.
Recent advancements have elucidated the multifaceted roles of Schlafen (SLFN) family, including SLFN5, SLFN11, SLFN12, SLFN13, and SLFN14, which are implicated in immunological responses. However, little is known about this gene family relation to malignancy development. The current study aimed explore diagnostic prognostic potential genes colorectal adenocarcinoma (COAD) through bioinformatics analysis. Leveraging advanced tools bulk RNA-sequencing single-cell sequencing, we conducted...
Triple-negative breast cancer (TNBC) remains a significant therapeutic challenge due to its unresponsiveness hormone and HER2-targeted treatments. This study investigated the potential of acetylated globotetraose (Ac-Gb4) as novel approach targeting glycolipid-mediated signaling in cells. We synthesized (Gb4) enhance membrane permeability while preserving biological recognition properties. Flow cytometry analysis revealed that Ac-Gb4 treatment significantly decreased SSEA3 SSEA4 expression...