A5016364041- Plant tissue culture and regeneration
- Connective Tissue Growth Factor Research
- Connective tissue disorders research
- Peroxisome Proliferator-Activated Receptors
- Transgenic Plants and Applications
- Phytochemistry and biological activity of medicinal plants
- Plant Pathogens and Fungal Diseases
- Eicosanoids and Hypertension Pharmacology
- Plant Genetic and Mutation Studies
- Toxin Mechanisms and Immunotoxins
- Herbal Medicine Research Studies
- Adipose Tissue and Metabolism
- NF-κB Signaling Pathways
- Fibroblast Growth Factor Research
- HIV Research and Treatment
- Immune Cell Function and Interaction
- Endometriosis Research and Treatment
- Metabolism, Diabetes, and Cancer
- Food Science and Nutritional Studies
- Monoclonal and Polyclonal Antibodies Research
- T-cell and B-cell Immunology
- Calcium signaling and nucleotide metabolism
- Hepatitis C virus research
- Quinazolinone synthesis and applications
- Blood groups and transfusion
Simpson Biotech Company (Taiwan)
2024
Indus Biotech (India)
2012-2022
Tamil Nadu Agricultural University
2020
National Taiwan University
2007-2018
National Health Research Institutes
2005-2008
National Defense Medical Center
2006
National Tsing Hua University
2005-2006
Sri Venkateswara University
1997-2002
Laryngeal and hypopharyngeal squamous cell carcinomas (LHSCCs) are common head neck cancers with a high propensity for lymph node (LN) lung metastasis. Here, we report that LHSCCs express levels of functional CXCR4 receptors, native chemokine stromal cell-derived factor-1 (SDF-1/CXCL12). Primary tumor immunohistochemistry from LHSCC patients has revealed significant expression CXCL12. Greater but not CXCL12 is correlated LN distant Reverse transcription-polymerase chain reaction western...
Peroxisome proliferator-activated receptor γ (PPARγ) is well-known as the of thiazolidinedione antidiabetic drugs. In this paper, we present a successful example employing structure-based virtual screening, method that combines shape-based database search with docking study and analogue search, to discover novel family PPARγ agonists based upon pyrazol-5-ylbenzenesulfonamide. Two analogues in show high affinity for, specificity to, act partial agonists. They also demonstrate glucose-lowering...
Connective tissue growth factor (CTGF) expression is elevated in advanced breast cancer and promotes metastasis. Chemotherapy response only transient most metastatic diseases. In the present study, we examined whether CTGF could confer drug resistance human cancer. patients who received neoadjuvant chemotherapy, was inversely associated with chemotherapy response. Overexpression of MCF7 cells (MCF7/CTGF) enhanced clonogenic ability, cell viability, to apoptosis on exposure doxorubicin...
Abstract Recent studies suggest AMP‐activated protein kinase (AMPK), an enzyme involved in energy homeostasis, might be a novel signaling pathway regulating inflammatory response, but the precise intracellular mechanisms are not fully understood. In this study, we have demonstrated that 5‐aminoimidazole‐4‐carboxamide riboside (AICAR), activator of AMPK, inhibited lipopolysaccharide (LPS)‐induced expression inducible nitric oxide synthase (iNOS) and cyclooxygenase‐2 (COX‐2) macrophages...
The synthesis and structure−activity relationship studies of novel indole derivatives as peroxisome proliferator-activated receptor (PPAR) agonists are reported. Indole, a druglike scaffold, was studied core skeleton for the acidic head part PPAR agonists. structural features (acidic head, substitution on indole, linker) were optimized first, by keeping benzisoxazole tail part, based binding functional activity at PPARγ protein. variations in introducing various heteroaromatic ring systems,...
In vitro clonal multiplication of Pterocarpus santalinus L. was achieved using mature nodal explants a 10-year-old elite quality tree. Combinations serial transfer technique and incorporation antioxidants (250mg/l L-ascorbic acid 50mg/l citric acid) into the culture medium helped to minimize browning improve explant survival during shoot sprouting. About 70% were sprouted on Murashige Skoog (MS) liquid containing 4.4μM 6-benzyladenine (BA). The harvest period also influenced bud break...
Amongst the many strategies aiming at inhibiting HIV-1 infection, blocking viral entry has been recently recognized as a very promising approach. Using diverse in vitro models and broad range of primary patient isolates, we report here that IND02, type A procyanidin polyphenol extracted from cinnamon, features trimeric pentameric forms displays an anti-HIV-1 activity against CXCR4 CCR5 viruses with 1–7 μM ED50 for trimer. Competition experiments, using surface plasmon resonance-based binding...
Multiple shoots of Spilanthes acmella Murr. were induced from hypocotyl segments obtained 1-week-old seedlings on Murashige and Skoog's (MS) medium containing benzyladenine (BA), isopentenyl adenine, naphthaleneacetic acid (NAA). High frequency shoot proliferation (95 %) maximum number per explant (10 ± 0.6) recorded with 0.5 mg dm-3 BA in combination 0.1 NAA. A was achieved by repeatedly subculturing the nodal multiplication medium. About 95 % vitro developed roots after transfer to half...
This study isolated agonists of peroxisome proliferator activated receptors (PPARs) from the green algae Chlorella sorokiniana, using a bioassay-guided purification strategy. PPARs are widely recognized as molecular drug targets for many diseases including hyperglycemia, diabetes, obesity and cancer. Two independent bioassays were developed. The first is scintillation proximity assay, ligand binding assay. other cell-based transcriptional activation assay which uses Dual-Luciferase reporter...
An outbreak of SARS-CoV-2 coronavirus (COVID-19) first detected in Wuhan, China, has created a public health emergency all over the world. The pandemic caused more than 340 million confirmed cases and 5.57 deaths as 23 January 2022. Although carbohydrates have been found to play role binding infection, cell surface glycans infection pathogenesis is still not understood. Herein, we report that spike protein S1 subunit binds specifically blood group A B antigens, S2 preference for Lea...
Type 2 diabetes has rapidly reached an epidemic proportion becoming a major threat to global public health. PPAR agonists have emerged as leading class of oral antidiabetic drugs. We report structure biology analysis novel indole-based explain the structure−activity relationships and present critical reasons for change in selectivity with orientation same scaffolds. The results would be helpful designing agonists.
Molecules derived from cinnamon have demonstrated diverse pharmacological activities against infectious pathogens, diabetes and inflammatory diseases. This study aims to evaluate the effect of cinnamon-derived molecule IND02 on adhesion leukocytes host cells. The anti-inflammatory ability IND02, a pentameric procyanidin type A polyphenol polymer isolated alcohol extract, was examined. Pretreatment with significantly reduced attachment THP-1 cells or neutrophils TNF-α-activated HUVECs...
<title>Abstract</title> <italic>Aloe vera</italic> is a popular medicinal plant in the cosmetic, pharmaceutical, and food industries. Acemannan (ACE), β-(1,4)-acetylated mannan, one of bioactive compounds isolated from <italic>A. gel. The pharmacological effects ACE have been reported regarding digestive disease protection, antimicrobia, prebiotic activity. Here, we used HaCaT cells as model to uncover potential biological functions keratinocytes. increased cell growth...
In the era of climate change with increasing global populace, there is a requisite for developing high yielding resilient varieties in shorter span. Integrating modern techniques high-throughput phenomics gains genomics would lead to increase efficiency breeding rapid development such varieties. The plant facilities vegetable have been recent years. High-throughput phenotyping involves use various imaging techniques, where images are collected and then analyzed some specialized software's....