A5110416544- Diamond and Carbon-based Materials Research
- Metal and Thin Film Mechanics
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Advanced Surface Polishing Techniques
- Advanced Battery Materials and Technologies
- Semiconductor materials and devices
- Nanoplatforms for cancer theranostics
- Supramolecular Chemistry and Complexes
- Electronic and Structural Properties of Oxides
- bioluminescence and chemiluminescence research
- Advancements in Battery Materials
- Force Microscopy Techniques and Applications
- Enzyme Structure and Function
- Protein Kinase Regulation and GTPase Signaling
- Protein Structure and Dynamics
- Topic Modeling
- Molecular Sensors and Ion Detection
- Advanced battery technologies research
- High Entropy Alloys Studies
- Lipid Membrane Structure and Behavior
- Adversarial Robustness in Machine Learning
- RNA modifications and cancer
- Methane Hydrates and Related Phenomena
- Autophagy in Disease and Therapy
Shandong University
2024-2025
Jiangsu University
2025
University of Notre Dame
2024
Shandong Academy of Pharmaceutical Sciences
2024
Guizhou University
2021-2023
Guangxi University
2020-2023
Shandong Jiaotong University
2021-2022
Shanghai University
2009-2012
S-Adenosyl-l-methionine (SAM)-responsive riboswitches play a central role in the regulation of bacterial gene expression at level transcription attenuation or translation inhibition. In this study, multiple independent Gaussian-accelerated molecular dynamics simulations were performed to decipher identification mechanisms SAM-III (SMK) on ligands SAM, SAH, and EEM. The results reveal that ligand binding highly affects structural flexibility, internal dynamics, conformational changes SAM-III....
Retrieval-Augmented Generation (RAG) is an advanced technique designed to address the challenges of Artificial Intelligence-Generated Content (AIGC). By integrating context retrieval into content generation, RAG provides reliable and up-to-date external knowledge, reduces hallucinations, ensures relevant across a wide range tasks. However, despite RAG's success potential, recent studies have shown that paradigm also introduces new risks, including robustness issues, privacy concerns,...
Rational structure and morphology design are of great significance to realize excellent Na storage for advanced electrode materials in sodium-ion batteries (SIBs). Herein, a cube-like core/shell composite single MnS nanocubes (≈50 nm) encapsulated N, S co-doped carbon (MnS@NSC) with strong CSMn bond interactions is successfully prepared as outstanding anode material SIBs. The shell significantly restricts the expansion volume successive sodiation/desodiation processes, demonstrated by situ...
Understanding the molecular mechanism of GTP-KRAS binding is significant for improving target roles KRAS in cancer treatment. In this work, multiple replica Gaussian accelerated dynamics (MR-GaMD) simulations were applied to decode effect Q61A, Q61H and Q61L on activity KRAS. Dynamics analyses based MR-GaMD trajectory reveal that motion modes behavior switch domain are heavily affected by three Q61 mutants. Information free energy landscapes (FELs) shows induce structural disorder disturb...
Mutations of G12 in KRAS have been involved different cancers. Multiple replica-Gaussian accelerated molecular dynamics (MR-GaMD) simulations are applied to investigate conformational changes the switch domains caused by G12C, G12D and G12R. Free energy landscapes suggest that G12R induce more energetic states compared GTP-bound WT make conformations disordered, which disturbs bindings effectors. Dynamics analyses based on MR-GaMD trajectory show not only change structural flexibility but...
<title>Abstract</title> Climbing robots have vital uses in uncharted terrain exploration, military intelligence collecting, and other areas. To address the drawbacks of classic wall-climbing robots, this study introduced a novel soft climbing robot constructed smart wood with switchable adhesion force. The experimental findings indicated that implemented research could effectively perform movements on diverse walls sloping pavements, enabled by temperature control through cold/hot water...
Hollow carbon spheres with 18.94 at% nitrogen doping and hierarchical pores deliver a high specific capacity, excellent capacity performance long cycling stability in Li–S batteries.
The β2 adrenergic receptor (β2AR), one of important members the G protein coupled receptors (GPCRs), has been suggested as an target for cardiac and asthma drugs. Two replicas Gaussian accelerated molecular dynamics (GaMD) simulations are performed to explore deactivation mechanism active β2AR bound by three different substrates, including agonist (P0G), antagonist (JTZ) inverse (JRZ). simulation results indicate that Gs is needed stabilize state β2AR. Without protein, could transit from...
Hyaluronan (HA) is a naturally occurring polysaccharide in the organism. As one of main components extracellular matrix, it plays an important role regulating various cellular processes, including proliferation, differentiation, inflammation, and immunity, through interaction with HA receptors. widely found human body, particularly skin joints, thus playing crucial functioning these tissues. The aging occurrence osteoarthritis are related to loss HA. Supplementing appropriate areas can delay...
A novel hemicucurbituril-based macrocycle, alternately consisting of amidobenzene and 2-imidazolidione moieties was designed synthesized. Based on the fragment coupling strategy, nitrobenzene-containing hemicucurbituril firstly prepared facilely under alkaline environment, reduction nitro groups produced desired amidobenzene-containing hemicucurbituril. As an original fluorescent chemosensor, it exhibited strong interactions with Fe3+ over other metal cations. The experimental evidence...
P-type hydrogenated nanocrystalline diamond (NCD) film on silicon substrate was realized by microwave plasma chemical vapor deposition (MPCVD) method followed hydrogen treatment. And then a metal-semiconductor field-effect transistor (MESFET), where ohmic contacts as source and drain were formed depositing gold Schottky gate contact with length L<sub>g</sub> of 10 μm metal aluminium, successfully fabricated surface p-channel based the above NCD film. Atomic force microscopy (AFM),...
Free-standing polycrystalline diamond films with a thickness of about 200 μm were grown by microwave plasma chemical vapor deposition (MPCVD) method. Raman spectra indicated high quality film the nucleation surface. AFM result surface was quite smooth mean roughness (RMS) 10 nm. The sheet carrier densities and resistivities hydrogenated surfaces under different annealing temperatures investigated Hall effect measurement. density resistivity remained in relatively stable range until...
Recent studies have proposed integrating Chain-of-Thought (CoT) reasoning to further enhance the reliability of Code Language Models (CLMs) in generating code, a step-by-step approach that breaks down complex programming tasks into manageable sub-problems. Advances this area introduced CoT models, specifically designed integrate effectively language achieving notable improvements code generation. Despite these advancements, security models has not been systematically studied. In study, we...
The highly c-axis-oriented AlN buffer layers were successfully deposited on the nucleation sides of free-standing diamond (FD) films by direct current (DC) magnetron sputtering method. influence parameters, such as gas pressure and plasma composition Ar-to-N2, properties thin investigated. X-ray diffraction (XRD) measurements showed that when was 0.2 Pa Ar-to-N2 3:1, higher intensity (002) peak narrower full width at half maximum (FWHM) detected, which meant high c-axis orientation quality...
200 μm thick free-standing polycrystalline diamond film has been grown by microwave plasma chemical vapor deposition (MPCVD) method. The nucleation surface of is characterized Raman scattering, scanning electron microscopy (SEM) and atomic force (AFM) AFM SEM results indicate the quite smooth with a mean roughness (RMS) about 10 nm. scattering result indicates high quality film. A field effect transistor fabricated on hydrogenated surface, using standard lithographic procedures. Device...