A5038445017- Bladder and Urothelial Cancer Treatments
- Neuroblastoma Research and Treatments
- Childhood Cancer Survivors' Quality of Life
- Radiomics and Machine Learning in Medical Imaging
- Urinary and Genital Oncology Studies
- Hepatitis B Virus Studies
- Cancer therapeutics and mechanisms
- Testicular diseases and treatments
- Lung Cancer Research Studies
- Hepatitis Viruses Studies and Epidemiology
- Glioma Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Vaccine Coverage and Hesitancy
- Adrenal and Paraganglionic Tumors
- Prostate Cancer Diagnosis and Treatment
- Pelvic floor disorders treatments
- Sarcoma Diagnosis and Treatment
- Ethics and Legal Issues in Pediatric Healthcare
- Neuroendocrine Tumor Research Advances
- Urinary Bladder and Prostate Research
- Cancer Immunotherapy and Biomarkers
- Enhanced Recovery After Surgery
- Cardiac, Anesthesia and Surgical Outcomes
- Renal and related cancers
- Renal cell carcinoma treatment
University of Pretoria
2014-2024
Steve Biko Hospital
2014-2023
Tygerberg Hospital
2021
Stellenbosch University
2021
Kalafong Hospital
2014
Abstract Background Outcome data for neuroblastoma in sub‐Saharan Africa are minimal, whereas poor outcome is reported low‐ and middle‐income countries. A multi‐institutional retrospective study across South was undertaken to determine outcome. Methods Patients treated between January 2000 December 2014 nine African pediatric oncology units were included. Kaplan–Meier curves Cox regression models employed two‐year survival rates identify prognostic factors. Results Data from 390 patients...
Hospital-acquired hepatitis B virus (HBV) infection has been well described and continues to occur worldwide. Recent nosocomial outbreaks have linked unsafe injection practices, use of multi-dose vials, poor staff compliance with standard precautions. This report describes a outbreak that occurred in pediatric hematology oncology unit large academic hospital, the epidemiological investigation outbreak, preventive measures implemented limit further in-hospital transmission.Outbreak including...
To implement a childhood cancer-specific nutritional algorithm adapted for the South African context interventions at time-set intervals to evaluate differences in status of newly diagnosed children with cancer.
PURPOSE Response assessment of classical Hodgkin lymphoma (cHL) with positron emission tomography-computerized tomography (PET-CT) is standard care in well-resourced settings but unavailable most African countries. We aimed to investigate correlations between changes PET-CT findings at interim analysis blood test results pediatric patients cHL 17 South centers. METHODS Changes ferritin, lactate dehydrogenase (LDH), erythrocyte sedimentation rate (ESR), albumin, total white cell count (TWC),...
Background. Hepatitis B is an important public health concern in South Africa (SA). The hepatitis virus (HBV) vaccine was introduced into the African Expanded Programme on Immunisation (EPI-SA) 1995. There no 'catch-up' programme place. duration of protection after vaccination SA population unknown. Waning vaccine-induced immunity leaves people at risk acquiring infection settings where prevalence high and horizontal transmission likely. Objective. To assess to HBV patients presentation a...
Many South African children live in poverty and food insecurity; therefore, malnutrition within the context of childhood cancer should be examined. Parents/caregivers completed Poverty-Assessment Tool (divided into risk groups) Household Hunger Scale questionnaire five pediatric oncology units. Height, weight, mid-upper arm circumference assessments classified malnutrition. Regression analysis evaluated association insecurity with nutritional status, abandonment treatment, one-year overall...
Achieving remission after induction therapy in high-risk neuroblastoma (HR-NB) is of significant prognostic importance. This study investigated induction-chemotherapy using three standard protocols the South African (SA) setting. Retrospective data 261 patients with HR-NB diagnosed between January 2000 and December 2016, who completed chemotherapy treatment were evaluated. The either OPEC/OJEC or St Jude NB84 protocol (NB84) rapid COJEC (rCOJEC). postinduction metastatic complete (mCR) rate,...
Lymphoma is the third most common paediatric cancer. Early detection of high-risk patients necessary to anticipate those who require intensive therapy and follow-up. Current literature shows that residual tumor avidity on PET (Positron Emission Tomography) following chemotherapy corresponds with decreased survival. However, value metabolic parameters has not been adequately investigated. In this retrospective study, we aimed evaluate prognostic other in adolescent Hodgkin lymphoma. We...
Abstract Objective To determine the overall survival (OS) and prognostic factors influencing outcomes in children adolescents with malignant extracranial germ cell tumours (MEGCTs) preparation for development of a harmonised national treatment protocol. Methods A retrospective folder review was undertaken at nine South African paediatric oncology units to document patient profiles, tumour treatment‐related data all biopsy‐proven MEGCTs from birth up including 16 years age. Results Between 1...
Abstract Purpose Low‐ and middle‐income countries (LMICs) reported a higher median age at diagnosis of neuroblastoma (NB) compared to high‐income countries. The aim was determine if the optimal diagnosis, which maximizes difference in overall survival between younger versus older patients South African population similar internationally validated 18 months cut‐point. Methods Four hundred sixty NB diagnosed 2000 2016 were included. Receiver operating characteristic (ROC) curves used predict...
Objectives: Pediatric sex cord stromal tumors (SCSTs) are extremely rare and there no reported data from Africa. The authors evaluated the outcomes of children adolescents with biopsy-proven SCSTs in preparation for introduction a national protocol. Materials Methods: Retrospective were collated 9 South African pediatric oncology units January 1990 to December 2015. Kaplan-Meier analysis was performed estimate overall survival (OS) event-free survival. Results: Twenty-three patients...
Background. The outcome of patients with neuroblastoma in South Africa has always been very poor. We conducted a retrospective study one state-funded paediatric oncology unit (POU), to describe the clinical course, evaluate prognostic factors and report outcomes neuroblastoma.Methods. analysed routine data from POU, gathered between 1993 2018. Kaplan-Meier curves were used illustrate 2-year survival rates possible factors.Results. Data 87 included analysed. median age was 41 months. majority...
Background: Nosocomial outbreaks of hepatitis B virus (HBV) have been well described. Horizontal transmission plays an important role in the epidemiology HBV sub-Saharan Africa, but mechanisms are poorly understood. Currently, South Africa has no national guidelines for prevention paediatric oncology units. Methods & Materials: A retrospective descriptive study a outbreak that started March 2012, was performed at Paediatric Haematology and Oncology Unit large tertiary hospital. Results:...
Surgical control has prognostic value in neuroblastoma (NB). Advanced NB is common at diagnosis South Africa. We investigated the pre-surgery factors that influenced decisions to perform surgical resections. included 204 patients with high-risk from a national retrospective study, who completed induction chemotherapy between 2000 and 2016.The median age was 32.4 months (IQR 15.1 - 53.5 months). Primary tumor resection achieved 76.9% of 0-18 age, 51.8% 18-60 51.7% older than 60 (p < 0.001)....
Background: Hepatitis B remains an important public health concern in South Africa. Despite the introduction of hepatitis vaccination 1995, prevalence chronic HBsAg positivity unacceptably high. Horizontal transmission plays role developing countries, and occurs mainly through body fluids like saliva. A recent nosocomial virus (HBV) outbreak involving 38 patients occurred paediatric haematology oncology unit a large tertiary hospital Africa from March 2012. Possible breaches standard...