A5005575012- Salivary Gland Disorders and Functions
- Salivary Gland Tumors Diagnosis and Treatment
- Oral Health Pathology and Treatment
- Oral and Maxillofacial Pathology
- Laser Applications in Dentistry and Medicine
- Mesenchymal stem cell research
- Oral microbiology and periodontitis research
- Botulinum Toxin and Related Neurological Disorders
- Oral and gingival health research
- Temporomandibular Joint Disorders
- Hydrogen's biological and therapeutic effects
- Ocular Surface and Contact Lens
- Proteoglycans and glycosaminoglycans research
- Nerve injury and regeneration
- Advanced Proteomics Techniques and Applications
- Dental Radiography and Imaging
- Dental Anxiety and Anesthesia Techniques
- Anesthesia and Sedative Agents
- Virus-based gene therapy research
- Pain Mechanisms and Treatments
- Oral health in cancer treatment
- Potassium and Related Disorders
- Cancer Research and Treatments
- Obstructive Sleep Apnea Research
- Cancer Diagnosis and Treatment
Hadassah Medical Center
2012-2025
Hebrew University of Jerusalem
2016-2025
Barzilai Medical Center
2024
University of California, Los Angeles
2014
National Institute of Dental and Craniofacial Research
2000-2002
National Institutes of Health
2000-2002
Burning Mouth Syndrome (BMS) is an intraoral chronic burning or dysesthetic sensation, without clinically evident causative lesions on clinical examination and investigation.
Orofacial pain (OFP) includes chronic conditions categorized into musculoskeletal (MS), neurovascular (NV), and neuropathic (NP) types, encompassing temporomandibular disorders (TMD), migraines, trigeminal neuralgia (TN), post-traumatic neuropathies, burning mouth syndrome (BMS). These significantly affect quality of life; yet, their underlying metabolic disruptions remain inadequately explored. Salivary metabolomics provides a non-invasive method to investigate biochemical alterations...
The purpose of this study was to examine the growth and morphology a salivary epithelial cell line (HSG) in vitro on several biodegradable substrata as an important step toward developing artificial gland. substrates examined were poly-L-lactic acid (PLLA), polyglycolic (PGA), two co-polymers, 85% 50% PLGA, respectively. formed into 20- 25-mm disks, cells seeded directly onto polymers or coated with specific extracellular matrix proteins. copolymer became friable over time aqueous media...
Impaired salivary gland (SG) function leading to oral diseases is relatively common with no adequate solution. Previously, tissue engineering of SG had been proposed overcome this morbidity, however, not yet clinically available. Multiwall inorganic (tungsten disulfide [WS2]) nanotubes (INT-WS2) and fullerene-like nanoparticles (IF-WS2) have many potential medical applications. A unexplored venue application their interaction SG, therefore, our aim was test the biocompatibility INT/IF-WS2 A5...
Objective. SS is an autoimmune exocrinopathy affecting ∼1 million patients in the USA that diagnosed mostly middle-aged women. Oral fluids (OFs) serving as mirror of body were suggested ideal non-invasive diagnostic tool. Previously we developed depletion techniques for OF high-abundance proteins to increase visualization low-abundance proteins. Therefore aim this study was examine effect pretreatments on identification potential biomarker candidates.
To evaluate, in an open trial, the pharmacotherapeutic efficacy of tricyclic antidepressant (TCA) drugs and gabapentin patients with persistent myofascial pain to identify patient characteristics that may predict treatment outcome.A stepped protocol was employed. All 42 having facial tenderness regional muscles were first prescribed amitriptyline, but those side effects subsequently transferred nortriptyline. In where no response TCAs observed, initiated. Outcome assessed by employing...
Proteomic characterization of human whole saliva for the identification disease-specific biomarkers is guaranteed to be an easy-to-use and powerful diagnostic tool defining onset, progression prognosis systemic diseases and, in particular, oral diseases. The high abundance proteins, mainly alpha amylase, hampers detection low abundant proteins appearing disease state therefore should removed. In present study a 2-DE was used analyze following removal amylase by affinity adsorption potato...
International Journal of Paediatric Dentistry 2010; 20: 235–241 Background: The aetiology low caries incidence in Down syndrome (DS) children is not entirely clear. Aim. To compare sialochemistry and oral mucosal pH between with (DS‐Ca) free (DS‐CaF), healthy (C‐Ca) (C‐CaF). Design. study group comprised 70 DS (mean age 4.41 ± 1.9 years); 32 9.22 2.7 years) served as control. Groups were further subdivided according to status: DS‐Ca, DS‐CaF, C‐Ca C‐CaF. Sialochemistry analysis included...
Background. Vascular calcifications have been documented in children with end-stage renal disease. However, only a few reports described abundant dental calculus formation suffering from chronic kidney disease (CKD). Moreover, scores (DCS) and their correlation severity not studied. Methods. DCS 74 young CKD patients were evaluated: 25 pre-dialytic (PrD), 18 on dialysis (D) 31 transplants (T) compared to 32 healthy participants (C). Saliva serum analysis included creatinine (Cr), urea (U),...
Recently, interest in finding disease bio-markers human body fluids including oral (OF), mainly saliva has increased. However, the physiologic differences salivary proteins according to gender and age should be explored establish a clinical diagnostic tool.To compare OF protein expression age, using proteomic approaches.Oral from 27 healthy volunteers (14 males, 13 females) was collected divided into three age-groups. were separated by means of 2D-SDS-PAGE. A total 51 37 spots identified...
Regeneration of the salivary glands' (SGs) normal function for patients with cancer head and neck treated irradiation would be a major contribution to their quality life. This could accomplished by re-implantation autologous SG cells into residual irradiated tissue or implantation tissue-engineered artificial SGs. Both methods depend on isolation able propagate differentiate epithelial cells. Recently, it has been shown that integrin α6β1–expressing (SGIE) have stem cell capabilities, but...
While saliva regulates the interplay between microbiota and oral immune system, mechanisms establishing postnatal salivary immunity are ill-defined. Here, we show that high levels of neutrophils neonatal Fc receptor (FcRn)-transferred maternal IgG temporarily present in murine glands a microbiota-independent manner. During weaning, neutrophils, FcRn, decrease glands, while polymeric immunoglobulin (pIgR) is upregulated growth arrest-specific 6 (GAS6)-dependent manner independent microbiota....
The use of Cone-Beam-Computed-Tomography (CBCT) is rapidly increasing in dentistry. This study aimed to evaluate CBCT among dentists across various fields and how it affected by measures. We sent an anonymous questionnaire Israeli dentists, which assessed the clinical (including requested output: cross-sectional-images (CSI), DICOM-files, interpretation report), knowledge, medico-legal issues imaging. Our survey was distributed conferences via e-mails with a response rate ~ 38% (387...
An essential structural feature of fluid-secreting epithelial tissues is the presence tight junctions. To develop a tissue-engineered organ capable fluid secretion, cellular component must establish these structures. As part efforts to create an engineered artificial salivary gland, we have examined ability candidate allogeneic graft cell line, HSG, produce several key junction proteins, as well exhibit functional activities consistent with effective strand formation. In contrast results...
Irradiated head and neck cancer patients suffer from irreversible loss of salivary gland (SG) function, along with significant morbidity compromised quality life. To date there is no biologically-based treatment for this distress. Adult stem cells are promising candidates autologous transplantation therapy in the context tissue-engineered artificial SGs or direct cell therapy. The major restrictions handling such their limited lifespan during vitro cultivation, resulting a narrow time-window...
Abstract Burning mouth syndrome (BMS) is characterized by a spontaneous and chronic sensation of burning in the oral mucosa, with no apparent signs. The underlying pathophysiological neuropathic mechanisms remain unclear. Here, we attempt to elucidate some these using proteomic profiling bioinformatic analyses whole-saliva (WS) from BMS patients compared WS healthy individuals. Qualitative quantitative was performed two dimensional gel electrophoresis (2-DE) mass spectrometry (q-MS). In...
Radiation therapy for cancer in the head and neck region leads to a marked loss of salivary gland parenchyma, resulting severe reduction secretions. Currently, there is no satisfactory treatment these patients. To address this problem, we are using both tissue engineering gene transfer principles develop an orally implantable, artificial fluid-secreting device. In present study, examined compatibility two biodegradable substrata potentially useful fabricating such We implanted Balb/c mice...