A5015049148- Birth, Development, and Health
- Gestational Diabetes Research and Management
- Adipose Tissue and Metabolism
- Pituitary Gland Disorders and Treatments
- Adrenal and Paraganglionic Tumors
- Reproductive Health and Technologies
- Metabolomics and Mass Spectrometry Studies
- Growth Hormone and Insulin-like Growth Factors
- Palliative Care and End-of-Life Issues
- Proteoglycans and glycosaminoglycans research
- Cancer Risks and Factors
- Infant Nutrition and Health
- Craniofacial Disorders and Treatments
- Head and Neck Anomalies
- Thyroid Cancer Diagnosis and Treatment
- Endometrial and Cervical Cancer Treatments
- Pharmacology and Obesity Treatment
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Diabetes Treatment and Management
- Thyroid Disorders and Treatments
- Regulation of Appetite and Obesity
- Neuroblastoma Research and Treatments
- Congenital Diaphragmatic Hernia Studies
- Metabolism and Genetic Disorders
- Metabolism, Diabetes, and Cancer
Northwestern University
2015-2021
Kaiser Permanente
2021
Lurie Children's Hospital
2016-2019
Drexel University
2009
University of Pennsylvania
2007
Philadelphia University
2007
Abramson Cancer Center
2007
<i>Background</i>: Previous research among specific cancer populations has shown high but variable symptom burden; however, very little is known about its extent and pattern the entire population of US survivors, which more clinically relevant to primary care physicians. <i>Methods</i>: To determine prevalence ongoing burden survivors compare it with general without cancer, we analyzed data from 2002 National Health Interview Survey, included 1,904 29,092 controls. Main outcome measures...
Growth-inhibitory chondroitin sulfate proteoglycans (CSPG) are a primary target for therapeutic strategies after spinal cord injury because of their contribution to the inhibitory nature glial scar tissue, major barrier successful axonal regeneration. Chondroitinase ABC (ChABC) digestion CSPGs promotes regeneration beyond lesion site with subsequent functional improvement. ChABC also has been shown promote sprouting spared fibers but it is not clear if recovery results from such plasticity....
Children and adolescents with gender sex diversity include (1) gender-nonconforming transgender individuals for whom identity or expression are incongruent birth-assigned (heretofore, transgender) (2) who have differences in development (DSD). Although these largely disparate groups, there is overlap the medical expertise necessary to care both diversity. In addition, groups face potential infertility sterility as a result of desired surgical therapies. The Ann & Robert H. Lurie Children's...
Abstract Context Newborn adiposity is associated with childhood obesity. Cord blood metabolomics one approach that can be used to understand early-life contributors and insulin resistance. Objective To determine the association of cord metabolites newborn hyperinsulinemia in a multiethnic cohort newborns. Design Cross-sectional, observational study. Setting Hyperglycemia Adverse Pregnancy Outcome Participants One thousand six hundred mother–newborn pairs. Main Measure C-peptide, birthweight,...
Summary Background Neonatal adiposity has many determinants and may be a risk factor for future obesity. Epigenetic regulation of metabolically important genes is potential contributor. Objectives The objective the study to determine whether methylation changes in LEP gene cord blood DNA are impacted by maternal environment or affect neonatal measures. Methods A cross‐sectional 114 full‐term neonates born healthy mothers with normal glucose tolerance was performed. Cord assayed leptin...
Background: Congenital hyperthyroidism can be a cause of failure to thrive, hyperactivity, developmental delay, and craniosynostosis during infancy. Most commonly, the condition occurs in setting maternal autoimmune thyroid disease. Rarely, congenital also occur secondary activating mutations within thyrotropin (TSH) receptor. Patient Findings: A Hispanic male infant presented at age 6 months with severe thyrotoxicosis. At time presentation he was being evaluated for squamosal suture...
Infants with higher adiposity at birth may be greater risk of developing obesity later in life. IGF-1 is important for intrauterine growth and a useful early life marker adiposity, thus risk. The aim this study was to determine the relationship between cord blood IGF-1, neonatal anthropometrics markers adiposity.A cross-sectional design utilized multiethnic cohort full-term neonates born healthy mothers normal glucose tolerance large university hospital. Neonatal collected after assayed...
Abstract Background Noninvasive encapsulated follicular variant of papillary thyroid carcinoma (noniEFVPTC) has low risk adverse outcome in adults, warranting reclassification as noninvasive neoplasm with papillary‐like nuclear features (NIFTP). In children, nodules have higher malignancy and it is unknown if FVPTC (EFVPTC) infiltrative (IFVPTC) tumors different behavior. We analyzed the clinicopathologic (FVPTC) subtypes our pediatric population to determine noniEFVPTC an indolent course...
Background Neonatal adiposity is a risk factor for childhood obesity. Investigating contributors to neonatal important understanding early life obesity risk. Epigenetic changes of metabolic genes in cord blood may contribute excessive and subsequent This study aims evaluate the association DNA methylation patterns with anthropometric measures leptin, biomarker adiposity. Methods A cross-sectional was performed on multiethnic cohort 114 full term neonates born mothers without gestational...
Use of metformin for weight loss children in a clinical setting has not been well described; therefore, we aimed to identify characteristics obese patients prescribed and evaluate changes anthropometric measures. Records aged 10 18 years without diabetes attending an academic endocrinology practice from 2009 2013 were reviewed. Analyses assessed measures (weight, body mass index [BMI], BMI z-score) over 12 months between those (n = 49) 142). Outcomes standardized before using multivariable...
The maternal metabolome serves as a proxy for the fetus’s metabolic environment, but its impact on newborn outcomes is largely unknown. To address this, we determined association of metabolites with adiposity and hyperinsulinemia in multiethnic cohort mother-newborn dyads. Targeted nontargeted metabolomics assays were performed fasting 1 hour serum samples from 1600 mothers four ancestry groups (Northern European, Afro-Caribbean, Mexican-American, Thai) who participated Hyperglycemia Adverse...
Newborn adiposity is associated with a higher risk of childhood obesity and earlier onset co-morbid metabolic diseases such as type 2 diabetes mellitus. The cord blood metabolome one early life marker that provides mechanistic insight into fetal fat deposition, insulin sensitivity, future disease integrates in-utero genetic, nutritional cues contribute to newborn phenotype. We hypothesize unique metabolomic signature or hyperinsulinemia might emerge predictive tool help identify at-risk...
Pubertal Tanner staging is a standard part of the pediatric physical examination and provides valuable insight into child's growth development. In practice, care practitioners have varying levels confidence expertise with staging. Currently, breast taught via illustrated images or limited hands-on practice on real patients during residency training.We used synthetic materials to develop lifelike, 3-dimensional, educational tool aimed at teaching medical students resident physicians how...