A5108710081- Nerve injury and regeneration
- Spinal Cord Injury Research
- Neurogenesis and neuroplasticity mechanisms
- Nerve Injury and Rehabilitation
- Signaling Pathways in Disease
- Pain Mechanisms and Treatments
- Muscle Physiology and Disorders
- Neurogenetic and Muscular Disorders Research
- Pluripotent Stem Cells Research
- Mesenchymal stem cell research
- Spinal Dysraphism and Malformations
- Neuropeptides and Animal Physiology
- MicroRNA in disease regulation
- Neuroinflammation and Neurodegeneration Mechanisms
- Muscle activation and electromyography studies
- Immunotherapy and Immune Responses
- Anesthesia and Neurotoxicity Research
- Proteoglycans and glycosaminoglycans research
- Neuroscience and Neuropharmacology Research
- Transcranial Magnetic Stimulation Studies
- Tissue Engineering and Regenerative Medicine
- Exercise and Physiological Responses
- Human-Automation Interaction and Safety
- Molecular Biology Techniques and Applications
- PI3K/AKT/mTOR signaling in cancer
Drexel University
2014-2025
Philadelphia University
2024
University of Massachusetts Lowell
2021-2022
University of Minnesota
2010
University of Minnesota System
2010
SIL International
2010
Carleton University
1996-2008
University of Arkansas for Medical Sciences
1994-2005
University of Arkansas at Little Rock
2005
Central Arkansas Veterans Healthcare System
1999
Chondroitinase-ABC (ChABC) was applied to a cervical level 5 (C5) dorsal quadrant aspiration cavity of the adult rat spinal cord degrade local accumulation inhibitory chondroitin sulfate proteoglycans. The intent enhance extension regenerated axons from distal end peripheral nerve (PN) graft back into C5 cord, having bypassed hemisection lesion at C3. ChABC-treated rats showed (1) gradual improvement in range forelimb swing during locomotion, with some animals progressing point raising their...
Activity-based therapies such as passive bicycling and step-training on a treadmill contribute to motor recovery after spinal cord injury (SCI), leading greater number of steps performed, improved gait kinematics, phase-dependent modulation reflexes, prevention decrease in muscle mass. Both tasks consist alternating movements that rhythmically stretch shorten hindlimb muscles. However, the paralyzed hindlimbs are passively moved by motorized apparatus during bike-training, whereas locomotor...
Transplants of fetal central nervous system (CNS) tissue into the acutely injured rat spinal cord have been demonstrated to differentiate and partially integrate with adjacent host neuropil. In present study, we examined potential for applying a transplantation approach chronic lesions. particular, were interested in learning whether host-graft fusion would be adversely affected by an advanced histopathology characterized part glial scar formation. Hemisection cavities prepared at lumbar...
Because there currently is no treatment for spinal cord injury, most patients are living with long-standing injuries. Therefore, strategies aimed at promoting restoration of function to the chronically injured have high therapeutic value. For successful regeneration, long-injured axons must overcome their poor intrinsic growth potential as well inhibitory environment glial scar established around lesion site. Acutely that regenerate into growth-permissive peripheral nerve grafts (PNGs)...
Nerve regeneration in an injured spinal cord is often restricted, contributing to the devastating outcome of neurologic impairment below site injury. Although implantation tissue-engineered scaffolds has evolved as a potential treatment method, outcomes remain sub-optimal. One possible reason may be lack topographical signals from these constructs provide contact guidance invading cells or regrowing axons. Nanofibers mimic natural extracellular matrix architecturally and therefore promote...
Activity-based therapies are routinely integrated in spinal cord injury (SCI) rehabilitation programs because they result a reduction of hyperreflexia and spasticity. However, the mechanisms by which exercise regulates activity pathways to reduce spasticity improve functional recovery poorly understood. Persisting alterations action GABA on postsynaptic targets is signature CNS injuries, including SCI. The depends intracellular chloride concentration, determined largely expression two...
Depletion or inhibition of core stress granule proteins, G3BP1 in mammals and TIAR-2 Caenorhabditis elegans , increases the growth spontaneously regenerating axons. Inhibition by expression its acidic “B-domain” accelerates axon regeneration after nerve injury, bringing a potential therapeutic strategy for peripheral repair. Here, we asked whether is viable to promote injured mammalian central nervous system (CNS) where axons do not regenerate spontaneously. B-domain was found transected...
Abstract Cycling exercise attenuates atrophy in hindlimb muscles and causes changes spinal cord properties after injury rats. We hypothesized that exercising soleus muscle expresses genes are potentially beneficial to the injured cord. Rats underwent at T10 were exercised on a motor‐driven bicycle. Soleus lumbar tissue used for messenger RNA (mRNA) analysis. Gene expression of brain‐derived neurotrophic factor (BDNF) glial cell line‐derived (GDNF) was elevated 11‐ 14‐fold, respectively, one...
Growth-inhibitory chondroitin sulfate proteoglycans (CSPG) are a primary target for therapeutic strategies after spinal cord injury because of their contribution to the inhibitory nature glial scar tissue, major barrier successful axonal regeneration. Chondroitinase ABC (ChABC) digestion CSPGs promotes regeneration beyond lesion site with subsequent functional improvement. ChABC also has been shown promote sprouting spared fibers but it is not clear if recovery results from such plasticity....
Spinal cord injury (SCI) induces neuropathic pain that is refractory to treatment. Central and peripheral immune responses SCI play critical roles in development. Although the dorsal horn have been implicated SCI-pain, mechanisms periphery, especially root ganglia (DRG), where nociceptor cell bodies reside, not well studied. Exercise an immunomodulator, we showed previously early exercise after reduces However, of exercise-mediated reduction are understood. Therefore, examined 1) underlying...
Although intra-axonal protein synthesis is well recognized in cultured neurons and during development <i>in vivo</i>, there have been few reports of mRNA localization and/or translation mature CNS axons. Indeed, previous work indicated that axons contain much lower quantities translational machinery than PNS axons, leading to the conclusion capacity for linked intrinsic a neuron regeneration, with showing less growth after injury neurons. However, when regeneration by facilitated, it not...
In this study, possible mechanisms underlying soleus muscle atrophy after spinal cord transection and attenuation of with cycling exercise were studied. Adult female Sprague-Dawley rats divided into three groups; in two groups the was transected by a lesion at T 10 . One group killed days later, another exercised for 5 starting transection. The third served as an uninjured control. All animals received continuous-release 5′-bromo-2′-deoxyuridine pellet before they killed. Transection alone...