A5025294427- Gastrointestinal motility and disorders
- Gastroesophageal reflux and treatments
- Pelvic floor disorders treatments
- Helicobacter pylori-related gastroenterology studies
- Eosinophilic Esophagitis
- Gastrointestinal disorders and treatments
- Congenital gastrointestinal and neural anomalies
- Esophageal and GI Pathology
- Dysphagia Assessment and Management
- Heavy Metal Exposure and Toxicity
- Diet and metabolism studies
- Diverticular Disease and Complications
- Drug Solubulity and Delivery Systems
- Gastric Cancer Management and Outcomes
- Gastrointestinal Bleeding Diagnosis and Treatment
- Colorectal Cancer Screening and Detection
- Stoma care and complications
- Inflammatory Bowel Disease
- Trace Elements in Health
- Bariatric Surgery and Outcomes
- Heavy metals in environment
- Microscopic Colitis
- Gut microbiota and health
- COVID-19 and healthcare impacts
- Analytical Methods in Pharmaceuticals
Michigan Medicine
2012-2023
University of North Carolina at Charlotte
2020-2023
Atrium Medical Cente
2021-2022
Carolinas Medical Center
2021-2022
University of Michigan
2010-2020
A. Alfred Taubman Health Care Center
2016-2020
Michigan United
2017-2020
Los Alamos National Laboratory
2020
University Health System
2011
University at Buffalo, State University of New York
2010
<h3>Abstract</h3> <b>Objectives</b>: To investigate the possible association between vitamin D receptor genotype and bone mineral density in a large group of postmenopausal twins. <b>Design</b>: Cross sectional twin study. <b>Setting</b>: Twin population based Britain. <b>Subjects</b>: 95 dizygotic (non-identical) pairs twins 87 monozygotic (identical) aged 50-69 years, postmenopausal, free diseases affecting bone, recruited from national register with media campaign. <b>Main outcome...
In this study, we determined the pH and buffer capacity of human gastrointestinal (GI) fluids (aspirated from stomach, duodenum, proximal jejunum, mid/distal jejunum) as a function time, 37 healthy subjects after oral administration an 800 mg immediate-release tablet ibuprofen (reference listed drug; RLD) under typical prescribed bioequivalence (BE) study protocol conditions in both fasted fed states (simulated by ingestion liquid meal). Simultaneously, motility was continuously monitored...
Although the microbiota in proximal gastrointestinal (GI) tract have been implicated health and disease, much about these microbes remains understudied compared to those distal GI tract. This study characterized across multiple sites over time healthy individuals. As part of a pharmacokinetics oral mesalamine administration, healthy, fasted volunteers (
Abstract The authors undertook this study to assess levels of cadmium exposure in the general population. Samples lung, liver, and kidney were obtained from 61 cadavers (43 males, 18 females; 2–89 yr age, mean age = 38.5 yr) who died accidental causes subject postmortem examinations at John Tonge Centre for Forensic Sciences, Queensland Health Scientific Services, Brisbane, Australia, 1997 1998. bladder urine also 22 cadavers. Tissue samples analyzed cadmium, zinc, copper with inductively...
It has been postulated that hypertonic saline (HS) might impair the antimicrobial effects of defensins within airways. Alternative non-ionic osmotic agents such as mannitol may thus be preferable to HS in promoting bronchial mucus clearance (BMC) patients with cystic fibrosis (CF). This study reports effect inhalation another agent, dry powder Mannitol (300 mg), compared its control (empty capsules plus matched voluntary cough) and a 6% solution on BMC 12 Mucus was measured using...
In vivo drug dissolution in the gastrointestinal (GI) tract is largely unmeasured. The purpose of this clinical study was to evaluate and systemic absorption BCS class IIa ibuprofen under fed fasted conditions by direct sampling stomach small intestinal luminal content. Expanding current knowledge will help establish physiologically relevant vitro models predictive dissolution. A multilumen GI catheter orally inserted into healthy human subjects. Subjects received a single oral dose (800 mg...
As an orally administered, locally acting gastrointestinal drug, mesalamine products are designed to achieve high local drug concentration in the (GI) tract for treatment of ulcerative colitis. The aim this study was directly measure and compare dissolution three formulations human GI correlate their with plasma. Healthy subjects were administered Pentasa, Apriso, or Lialda. fluids aspirated from stomach, duodenum, proximal jejunum, mid distal jejunum regions. Mesalamine (5-ASA) its primary...
Small intestinal bacterial overgrowth (SIBO) is often present in patients with chronic pancreatitis (CP) persistent steatorrhea, despite pancreatic enzyme replacement therapy. Overall prevalence of SIBO, diagnosed by glucose breath test (GBT), varies between 0% and 40% but 0%-21% those without upper gastrointestinal (GI) surgery. We investigated the nonsurgical independent predictors SIBO CP GI surgery.Two hundred seventy-three ≥18 years old had a presumptive diagnosis GBT 1989 2017. defined...
Abstract Background Esophageal pressure topography ( EPT ) diagnosis of ineffective esophageal motility IEM can be non‐specific with unclear clinical significance. Aims To determine whether peristaltic vigor or lower sphincter LES integrity is associated poor clearance and acid reflux in . Methods Bolus on high‐resolution impedance manometry HRIM available studies patients were retrospectively reviewed. was assessed using both line tracing colored contour methods parameters, bolus clearance,...
Objective Abdominal obesity has been associated with erosive oesophagitis (EO) and Barrett's oesophagus (BO). As gluteofemoral protects against diabetes mellitus cardiovascular disease, we hypothesised that would be inversely EO BO. Design We conducted a cross-sectional study on 822 male colorectal cancer screenees who were recruited to also undergo upper endoscopy. An additional 80 patients BO clinically detected by endoscopy referred for clinical indications shortly after their diagnoses...
Abstract Background Functional Lumen Imaging Probe (EndoFLIP) tests typically measure static pyloric parameters, but the pylorus exhibits phasic variations on manometry. Dynamic changes in function have not been quantified using EndoFLIP, and impact of Gastric Per‐Oral Endoscopic Myotomy (G‐POEM) dynamic activity gastroparesis is unknown. Methods EndoFLIP balloon inflation to 30, 40, 50 mL was performed mean, maximum, minimum values variability diameter distensibility before after G‐POEM 20...
This study was undertaken to assess changes in zinc and copper homeostasis human tissues that could be attributed exposure environmental cadmium, using samples of lung, liver kidney cortex 61 Queensland residents, aged 2 89 years, who had died accidental causes. None the subjects were exposed cadmium workplace. Levels showed inverse associations with donor age whereas lung only association gender. Lung levels females 14% lower than males. Zinc found exist at least two pools; one associated...