A5031187925- Particle physics theoretical and experimental studies
- High-Energy Particle Collisions Research
- Quantum Chromodynamics and Particle Interactions
- Advancements in Battery Materials
- Advanced Battery Materials and Technologies
- Heart Failure Treatment and Management
- Cardiac pacing and defibrillation studies
- Receptor Mechanisms and Signaling
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Function and Risk Factors
- Liver Disease and Transplantation
- Supercapacitor Materials and Fabrication
- Technology Adoption and User Behaviour
- Ferroelectric and Piezoelectric Materials
- Cardiomyopathy and Myosin Studies
- Liver Disease Diagnosis and Treatment
- Pulmonary Hypertension Research and Treatments
- Extraction and Separation Processes
- Advanced Condensed Matter Physics
- Advanced Chemical Physics Studies
- Higher Education Practises and Engagement
- Neutrino Physics Research
- Reflective Practices in Education
- Atrial Fibrillation Management and Outcomes
- Consumer Retail Behavior Studies
Glasgow Caledonian University
2016-2022
University of Liverpool
2016-2021
Abertay University
2016-2020
University of Edinburgh
1975-2020
General Sciences (United States)
2014-2019
University of Oxford
2006-2014
University of the West of Scotland
2013-2014
North Carolina State University
2013
Technology Applications (United States)
2013
University of Colorado Denver
1993-2012
Beta-blocker therapy may improve cardiac function in patients with idiopathic dilated cardiomyopathy. We tested the hypothesis that beta-blocker produces favorable functional effects cardiomyopathy by altering expression of myocardial genes regulate contractility and pathologic hypertrophy.
Using quantitative RT-PCR in RNA from right ventricular (RV) endomyocardial biopsies intact nonfailing hearts, and subjects with moderate RV failure primary pulmonary hypertension (PPH) or idiopathic dilated cardiomyopathy (IDC), we measured expression of genes involved regulation contractility hypertrophy. Gene was also assessed LV (left ventricular) free wall endomyocardium hearts end-stage IDC undergoing heart transplantation donors. In failing downregulation beta1-receptor mRNA protein,...
Lithium intercalation compounds based on lithium manganese oxides are of great importance as positive electrodes for rechargeable batteries. It is widely accepted that Li+ may be extracted (deintercalated) from such accompanied by oxidation Mn up to a maximum state +4. However, it has been suggested recently further removal possible. Among the mechanisms have proposed charge balance beyond +4 or loss O2-. To investigate this phenomenon we selected Li2MnO3, layered compound Li[Li1/3Mn2/3]O2...
Background: Methadone is an effective treatment for opioid dependency and chronic pain. A methadone derivative, levacetylmethadol, was withdrawn from the European market after being associated with torsade de pointes. To date, no association between this arrhythmia has been described. Objective: evaluate a series of methadone-treated patients experiencing Design: Retrospective case series. Setting: maintenance programs in United States pain management center Canada. Patients: 17 who...
To investigate the relationship between daily dose of synthetic opioid methadone and corrected QT (QTc) interval in a series methadone-treated patients who developed torsade de pointes.Retrospective case analysis.Outpatient pain management center maintenance treatment programs.Seventeen pointes while receiving very high doses methadone.The QTc intervals were calculated for each patient. The was assessed adjusted clinical characteristics that may have independently prolonged cardiac...
The electrochemical activity of Li2MnO3 in non-aqueous media has been investigated and found to involve neither Mn(4+)-Mn5+ oxidation nor simultaneous O2- removal but exchange Li+ by H+, the latter being generated electrolyte.
Low levels of trivalent cations were utilized to stabilize spinel cathode materials against capacity decline during electrochemical cycling. Of the several single‐phase products obtained, only those with and prevented fade, , exhibited acceptable initial reversible capacity. The external particle morphology was unchanged by preparation or admetal, internal structures all converted cong tou (onion) configurations product synthesis. Grain size played a surprising role in performance: <25 μm...
Adrenergic activation is an important determinant of outcomes in chronic heart failure. activity regulated part by prejunctional alpha(2C)-adrenergic receptors (ARs), which exhibit genetic variation humans. Bucindolol a novel beta-AR blocking agent that also lowers systemic norepinephrine and thus sympatholytic agent. This study investigated whether alpha(2C)-AR polymorphisms affect effects bucindolol patients with failure.In the beta-Blocker Evaluation Survival Trial, adrenergic was...
The stoichiometry, stability and polymorphism of the perovskite-related solid solutions, Li0.5 – 3xRE0.5 +xTiO3: RELa, Nd, has been studied. For both series, data are presented in form a temperature vs. composition phase diagram. Unit cell for different polymorphs (three La system, four Nd system) presented, together with on thermal history dependence lattice parameters. microstructure selected ceramic samples were analysed by electron microprobe techniques.
A 3-year prospective, blinded, multicenter study was done to assess the efficacy of early ribavirin intervention in mild respiratory syncytial virus illness children with bronchopulmonary dysplasia or congenital heart disease. cohort 178 younger than 36 months age disease were followed. Forty-seven infants whose infection resulted symptoms ≤72 hours' duration received (n=20) water placebo aerosol (n=27) either a hospital at home. Outcome measures included and analog score, room air oxygen,...
The most common cause of chronic heart failure in the US is secondary or primary dilated cardiomyopathy (DCM). DCM phenotype exhibits changes expression genes that regulate contractile function and pathologic hypertrophy. However, it unclear if any these alterations gene are disease producing modifying.One approach to providing evidence for cause-effect a disease-influencing quantitatively compare by employing serial measurements longitudinal experimental design. We investigated quantitative...
Nonstoichiometric layered LixMnyO2 compounds with the O3 structure (α-NaFeO2 type), space group R3̄m, were synthesized by ion exchange from sodium precursors NaxMnyO2. Such lithium intercalation are important in context of rechargeable batteries since they offer key advantages lower cost, toxicity, and higher safety when compared LiCoO2, which is used presently as positive electrode these devices. By varying synthesis conditions precursor ion-exchange process, significant variations vacancy...