A5080197144- Cardiac electrophysiology and arrhythmias
- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Poisoning and overdose treatments
- Cardiovascular Function and Risk Factors
- Eating Disorders and Behaviors
- Heart Rate Variability and Autonomic Control
- Blood Pressure and Hypertension Studies
- Cardiac pacing and defibrillation studies
- Cardiac Imaging and Diagnostics
- Heart Failure Treatment and Management
- Ion channel regulation and function
- Cardiac Health and Mental Health
- Cardiovascular Effects of Exercise
- Antiplatelet Therapy and Cardiovascular Diseases
- Opioid Use Disorder Treatment
- ECG Monitoring and Analysis
- Venous Thromboembolism Diagnosis and Management
- Cardiovascular Disease and Adiposity
- Pharmaceutical Practices and Patient Outcomes
- Cardiomyopathy and Myosin Studies
- Cardiovascular Syncope and Autonomic Disorders
- Acute Myocardial Infarction Research
- Cardiovascular Health and Risk Factors
- Peripheral Artery Disease Management
Children's Hospital of Pittsburgh
2023-2024
XinHua Hospital
2023-2024
Lund University
2023-2024
University of Pittsburgh
2023-2024
Clarion University
2023-2024
United States Food and Drug Administration
2023-2024
Nashville Oncology Associates
2023
Denver Health Medical Center
2013-2022
University of Colorado Denver
2013-2022
Health and Hospital Corporation
2007-2022
Background: Methadone is an effective treatment for opioid dependency and chronic pain. A methadone derivative, levacetylmethadol, was withdrawn from the European market after being associated with torsade de pointes. To date, no association between this arrhythmia has been described. Objective: evaluate a series of methadone-treated patients experiencing Design: Retrospective case series. Setting: maintenance programs in United States pain management center Canada. Patients: 17 who...
Description: An independent panel developed cardiac safety recommendations for physicians prescribing methadone. Methods: Expert members reviewed and discussed the following sources regarding methadone: pertinent English-language literature identified from MEDLINE EMBASE searches (1966 to June 2008), national substance abuse guidelines United States other countries, information regulatory authorities, physician awareness of adverse effects. Recommendation 1 (Disclosure): Clinicians should...
Background— Secondhand smoke exposure increases the risk of acute myocardial infarction (AMI). One study (Helena, Mont) examined issue and found a decrease in AMI associated with smoke-free ordinance. We sought to determine impact ordinance on admission rates another geographically isolated community (Pueblo, Colo). Methods Results— assessed hospitalizations Pueblo during 3-year period, 1.5 years before after implementation compared hospitalization among individuals residing within city...
To investigate the relationship between daily dose of synthetic opioid methadone and corrected QT (QTc) interval in a series methadone-treated patients who developed torsade de pointes.Retrospective case analysis.Outpatient pain management center maintenance treatment programs.Seventeen pointes while receiving very high doses methadone.The QTc intervals were calculated for each patient. The was assessed adjusted clinical characteristics that may have independently prolonged cardiac...
Objectives. We evaluated whether a program to prevent coronary heart disease (CHD) with community health workers (CHWs) would improve CHD risk in public and care settings. Methods. The CHWs provided point-of-service screening, education, coordination residents 34 primarily rural Colorado counties. utilized motivational interviewing navigated those at for into medical lifestyle resources. A software application generated real-time 10-year Framingham Risk Score (FRS) guideline-based...
ABSTRACT In an effort to enhance patient safety in opioid treatment programs, the Substance Abuse and Mental Health Saervices Administration convened a multi-disciplinary Expert Panel on Cardiac Effects of Methadone. members (Appendix A) reviewed literature, regulatory actions, professional guidances, program experiences regarding adverse cardiac events associated with methadone. The concluded that, extent possible, every should have universal Risk Management Plan (incorporating clinical...
The exact medical complications, leading to the well-known high risk of death in patients with anorexia nervosa (AN), remain elusive. Such deaths are often abrupt no satisfactory explanation. Suspected causes include cardiac QTc prolongation and, turn, torsade de pointes (TdP). Psychotropic medications prescribed these linked prolongation. AN is also presumed cause heart failure due malnutrition increased susceptibility prolongation, and TdP, resulting sudden death. Recent literature,...
Background: Point-of-care (POC) lipid testing is increasingly used in community-and office-based practice. Two analyzers commonly the US are CardioChek PA and Cholostech LDX. Both directly measure total cholesterol (TC) high-density lipoprotein (HDL-C), mandatory values calculating a Framingham Risk Score (FRS). The FRS turn informs clinician of need for lipid-modifying therapy degree therapeutic intensity. Objective: To compare performance Cholestech Methods: Staff members from Colorado...
To assess the relative frequency of reporting adverse events involving ventricular arrhythmia, cardiac arrest, corrected QT interval (QTc) prolongation or torsade de pointes to US Food and Drug Administration (FDA) between buprenorphine methadone.
To evaluate the effects of methadone on QT-interval dispersion.Single-center, prospective, cohort study.Methadone maintenance treatment facility.One hundred eighteen patients who were newly admitted to facility. Intervention. Twelve-lead electrocardiograms (ECGs) performed in at both baseline and 6 months after start therapy.The ECGs manually interpreted, investigators blinded time interval dose. At least eight discernible ECG leads required for study inclusion. Mean differences between...
Long-acting opioids are a leading cause of accidental death in the United States, and methadone is associated with greater mortality rates. Whether this increase related to proarrhythmic properties unclear.To describe methadone-associated arrhythmia events reported U.S. Food Drug Administration Adverse Event Reporting System (FAERS).Description national adverse event registry data before after publication 2002 report describing an association between arrhythmia.FAERS, November 1997 June...
Objective To estimate the early prevalence of various electrocardiographic (EKG) abnormalities in patients with systemic lupus erythematosus (SLE) and to evaluate possible associations between repolarization changes (increased corrected QT [QTc] dispersion [QTd]) clinical laboratory variables, including anti‐Ro/SSA level specificity (52 or 60 kd). Methods We studied adult SLE from 19 centers participating Systemic Lupus International Collaborating Clinics (SLICC) Inception Registry....