Background. Secondary edematous breast cancer (SEBC) is a nodal that accounts for 5–10% of and characterized by an aggressive clinical course. One the key factors in progression SEBC stromal component, which constant interaction with cells. Purpose – study to improve morphological criteria diagnosis prognosis based on clinical, molecular biological characteristics component tumors. Materials methods. Two groups were formed: Group I 30 cases, II 15 cases locally advanced without edema...

Background. Despite the fact that a lot of information on molecular genetic changes in lung cancers has been accumulated, there is still knowledge gap regarding determination key factors oncogenesis and trigger cause metastasis progression small cell cancer (SCLC). The problem comprehensive assessment prognostic importance changes, range IHC markers are used for diagnosing prognosing SCLC, impact epithelial-mesenchymal transformation (EMT) processes risk development tumor process lethal...

Background. Pancreatoduodenectomy is a radical surgical intervention in case of neoplasms the pancreatoduodenal zone. Assessment changes pancreatic parenchyma at preoperative stage will allow appropriate therapeutic and preventive measures to be taken reduce frequency fistula. The purpose study: determine diagnostic significance non-invasive imaging methods assessment fibrous patients with Materials methods. study included 82 who underwent pancreatoduodenectomy for age varied from 34 77...

The aim of this study is to establish modern, global trends in the diagnosis mechanical asphyxia.
 Materials and methods: search bibliographic method (theoretical analysis, systematization classification library catalogues, printed electronic sources on asphyxia) from open anchor databases Scopus preview, Web Science using information retrieval systems Google Scholar, Open Ukrainian Citation Index (OUCI), ScienceDirect Internet.
 Results: asphyxia, as one most common types violent...

The article presents the data of modern literature about malignant epithelial ovarian tumors. Since publication 3rd edition WHO classification tumors, there have been significant changes in views on etiology, morphogenesis and prognosis these Studies recent years allowed us to make scheme carcinoma grading, define morphological groups a new way. This highlight controversial issues those aspects, study which should focus scientists future.

Introduction: Vascular endothelium function interruption has the main role among mechanisms of development and progression chronic kidney disease. In numerous experimental clinical studies, it was proved that activated vascular is a structural functional unit matches processes inflammation with intravascular coagulation, fibrinolysis haemorheological disorders. The aim: To identify special features morphological structure in vessels, coronary arteries aorta during disease.Materials methods:...

Introduction: Chronic hyperglycemia as the main link in DM pathogenesis leads to systemic vessels and nerves lesion with chronic bone complications development consequently. The aim: To evaluate influence of on reparative osteogenesis after perforated tibial fracture rats. Materials methods: A total 30 white adult rats were subdivided into two groups: 15 healthy Group 1 (control) alloxan induced 2 (investigated) carried out experiment 10th, 20th 30th day fracture. Hyperglycemia was...

The aim: to find the optimal combination of immunohistochemical markers for differential diagnosis and prognosis small cell lung cancer in biopsy samples.
 Materials methods. tumor specimens were divided into 3 groups: 1) 25 samples before treatment; 2) procured from autopsies patients, who underwent chemotherapy; 3) 15 other tumors histologically similar SCLC. All formalin fixed paraffin embedded (FFPE). Immunohistochemical study performed with 5 primary antibodies: CD56, p16ink4A,...

Up to this day, there is still no sufficient data on immunohistochemical characteristics of intravenous neoplastic thrombi, as well general theory about their formation process.Aim. In order clarify the pathogenesis macroscopic proliferation renal cell carcinoma, both with and without invasion, in group 94 patients expression MMP-9, type IV collagen, a marker endothelial cells (CD 31) vascular growth factor (VEGF) were assessed by tests.Methods results. It was determined, that MMP-9 VEGF...

It was shown the review of world literature about role smoking and decreased food during pregnancy, as most important environmental factors that cause intrauterine growth retardation delayed development children their incidence in later life. The results our experimental research authors demonstrated combined effect passive reducing pregnancy without affecting on body weight offspring at birth, clearly inhibits somatic early period afternatal leads to profound metabolic, hormonal changes,...

Background. Infections of fetuses and newborns caused by Klebsiella themselves in polymicrobial associations have short incubation period, as well a high percentage deaths. Intrauterine infection fetus fetal chronic hypoxia should be considered conditions that require lot adaptive changes where one the most important roles is performed adrenal glands. Objective: to identify influence mother K.pneumoniae on cortex. Methods: During experiment, laboratory rats were divided into 3 groups. Group...

Background. Stroma is a crucial factor in the growth and progression of prostate cancer. However, morphological molecular biological signs cancer stroma that define prognosis disease have been investigated insufficiently. Objective. To identify relationships between morphological, immunohistochemical (vimentin, smooth muscle actin-α, MMP-9, collagen type IV) characteristics criteria aggressive clinical behavior, risk recurrence Metods. tumors was quantified 112 patients treated with radical...

Background. Diffuse glioma is one of the most common among tumors central nervous system (CNS). Epidemiological and morphological researches diffuse gliomas allow to find prevalent histotypes these in Kharkiv region. Objective. To study outer appearance histological structure population Methods. The research based on case histories patients with their biopsies period from 2000 2014. statistical data was processed Microsoft Excel. Results. We analysed 1540 primery incidence CNS region...

Today proved that the cause of many diseases are unfavorable conditions for development fetus in womb, caused by exposure to pregnant toxicants exogenous nature, which include nicotine, and a violation its feeding. However, literature does not answer question - what is impact smoking on thyropathies offspring. In an experimental model combined effects passive reduce energy intake food rats during pregnancy found their descendants characterized high percentage deaths first months life, delay...

Based on examination of the stroma 181 papillary thyroid icrocarcinomas and detection relationship with stage disease using NM system, it was discovered that desmoplasia maturity are important prognostic criteria. Lack desmoplasia, mature mixed associated I, severe immature type — III, IV disease.

Small cell lung cancer (SCLC) is one of the most aggressive tumor human body and has morphological features cancers with epithelial-mesenchymal transformation (EMT). The aim our study to improve for SCLC course prediction based on researching EMT stem cells phenotype at molecular-biological level. prognostic significance pancytokeratin, vimentin, E-cadherin N-cadherin expression, stage expression CD44 overall survival their influence spread were established. It was proved that presence...

Background. There is a huge number of algorithms for the diagnosis and prognosis clinical course non-invasive bladder cancer (NIBC). They are based on both morphological features data from immunohistochemical (IHC) studies in which large markers, including p53, Ki-67, VEGF, E-cadherin, MMP, bcl, etc., were used. Of scientific practical interest comprehensive assessment prognostic value main IHC markers used cancer, impact epithelial-mesenchymal transition (EMT) processes immune response risk...

Серед морфологічних критеріїв прогнозу у хворих на меланому шкіри найбільше значення мають товщина, глибина інвазії,виразка пухлини, наявність мікросателітів і метастазів регіонарні лімфовузли, ступінь проліферативної активності пухлин них клітин, інвазія їх судини. Значення клініко-анатомічного типу та клітинного варіанту меланоми, пігментації, вираженість ній запальної інфільтрації, фіброплазії, ознак регресії є дискутабельним.

The article analyzes the data of immunohistochemical examination soft tissues in area foreign body after gunshot wounds at different time. Histological changes capsule were detailed with help chronic inflammation markers, formation pathological type collagen and endothelial cells. features regeneration connective tissue structures are shown.