A5015571981- Hearing Loss and Rehabilitation
- Hearing, Cochlea, Tinnitus, Genetics
- Noise Effects and Management
- Reconstructive Surgery and Microvascular Techniques
- Speech and Audio Processing
- Ear Surgery and Otitis Media
- Total Knee Arthroplasty Outcomes
- Orthopaedic implants and arthroplasty
- Chemical Synthesis and Reactions
- Bone fractures and treatments
- Surgical site infection prevention
- Lymphatic System and Diseases
- Orthopedic Infections and Treatments
- Synthesis and Biological Evaluation
- Angiogenesis and VEGF in Cancer
- Microwave-Assisted Synthesis and Applications
- Protease and Inhibitor Mechanisms
- Seed Germination and Physiology
- Facial Nerve Paralysis Treatment and Research
- Banana Cultivation and Research
- Seismic Waves and Analysis
- Phonocardiography and Auscultation Techniques
- Conducting polymers and applications
- RNA regulation and disease
- Delphi Technique in Research
Washington University in St. Louis
2020-2025
Harvard University
2023-2024
Temple University
2023-2024
American Academy of Otolaryngology — Head and Neck Surgery
2023-2024
National Institute on Deafness and Other Communication Disorders
2022-2023
May Institute
2023
Cochlear (United States)
2023
AID Atlanta
2023
Cochlear (Australia)
2023
Stryker (Switzerland)
2023
Abstract Although significant progress has been made in understanding outcomes following cochlear implantation, predicting performance remains a challenge. Duration of hearing loss, age at and electrode positioning within the cochlea together explain ~ 25% variability speech-perception scores quiet using implant (CI). Electrocochleography (ECochG) responses, prior to account for 47% variance same measures. No study date explored CI noise , more realistic measure natural listening. This aimed...
Objective To evaluate whether electrocochleography (ECochG)-guided pull-back of the perimodiolar electrode improves proximity, hearing preservation (HP), and cochlear implant performance. Study Design Prospective cohort study Setting Tertiary referral center. Patients 77 adult CI recipients with residual acoustic (low-frequency pure-tone average 125, 250, 500 Hz; LFPTA ≤80 dB HL) Intervention Unilateral implantation, comparing conventional insertion (N = 31) ECochG-guided 46). The guided...
Objectives: Modern cochlear implants (CIs) use varying-length electrode arrays inserted at varying insertion angles within variably sized cochleae. Thus, there exists an opportunity to enhance CI performance, particularly in postlinguistic adults, by optimizing the frequency-to-place allocation for electrical stimulation, thereby minimizing need central adaptation and plasticity. There has been interest applying Greenwood or Stakhovskaya et al. function (describing tonotopic map)...
Objectives: Due to the challenges of direct in vivo measurements humans, previous studies cochlear tonotopy primarily utilized human cadavers and animal models. This study uses implant electrodes as a tool for intracochlear recordings acoustically evoked responses achieve two primary goals: (1) map cochlea, (2) assess impact sound intensity creation an artificial “third window” on this tonotopic map. Design: Fifty patients with hearing loss received electrode arrays. Postimplantation,...
1) To determine the relationship of electrocochleography (ECochG) responses measured on promontory with at round window (RW) and various intracochlear sites. 2) evaluate if ECochG correlate postoperative speech-perception performance using cochlear implant (CI).Prospective cohort study.Tertiary referral center.Ninety-six adult CI recipients no malformations or previous otologic surgery.Acoustically evoked were intraoperatively both extracochlear locations. total response (ECochG-TR), a...
Cochlear implantation produces remarkable results in postlingual deafness, although auditory outcomes vary. Electrocochleography (ECochG) has emerged as a valuable tool for assessing the cochlear-neural substrate and evaluating patient prognosis.
Electrocochleography (ECochG) recordings during cochlear implantation have shown promise in estimating the impact on residual hearing. The purpose of study was (1) to determine whether a 250-Hz stimulus is superior 500-Hz detecting hearing decrement and if so; (2) evaluate crossing tonotopic, characteristic frequency (CF) place partly explains problems experienced using 500-Hz.Multifrequency ECochG comprising an alternating, interleaved acoustic complex 250- stimuli used elicit microphonics...
Abstract Objective To examine the association between preoperative comorbidities and cochlear implant speech outcomes. Study Design Retrospective cohort. Setting Tertiary referral center. Patients A total of 976 patients who underwent implantation (CI) January 2015 May 2022. Adult with follow-up, audiologic data, a standardized anesthesia note were included. Exposure Comorbidity Evaluation 27 (ACE-27) based on notes. Main Outcome Measures Postoperative change in consonant–nucleus–consonant...
Predicting cochlear implant performance: Moving beyond single biomarkers and leveraging artificial intelligence Matthew Shew, Amit Walia, Craig A. Buchman highlight that the significant variability in speech perception among users can be addressed by using a multi- faceted approach incorporates emerging technologies like machine learning to improve outcome prediction models. Cochlear implants (CIs) represent one of most successful neural prostheses, providing discrete frequency intensity...
Objective Evaluate variable qualification criteria for cochlear implant (CI) recipients and 12-month speech perception outcomes. Study Design Retrospective cohort study. Setting HERMES national database nonoverlapping single-institution CI database. Patients A total of 2,124 adult unilateral categorized by qualifying status: AzBio in quiet (n = 1,239), +10 dB SNR (but not quiet; n 519), +5 or SNR; 366); CNC ≤40% 1,037), 41% to 50% 31), 51% 60% 20). Interventions CI. Main Outcome Measures...
To assess whether postoperative speech recognition after cochlear implantation (CI) differ between age groups of 80 to 89 and 90+. Retrospective cohort study. Tertiary academic referral center. Older adult (80+ years old) bilateral sensorineural hearing loss patients undergoing CI. Therapeutic, Speech testing battery at 3, 6, 12 months postoperatively. Self-reported balance vertigo symptoms were also assessed. A total 221 included in this study, with 171 cases ages 50 ≥90 old. 60.3% had an...
Objectives: Machine learning (ML) is an emerging discipline centered around complex pattern matching and large data-based prediction modeling can improve precision medicine healthcare. Cochlear implants (CI) are highly effective, however, outcomes vary widely, accurately predicting speech perception performance between patients remains a challenge. This study aims to evaluate the ability of ML predict among CI recipients at 6-month post-implantation using only preoperative variables on one...
Optimizing outcomes: The role of surgical technique and intraoperative factors in cochlear implant performance Variability remains a significant challenge for clinicians patients. Contributors from Washington University School Medicine investigate how techniques adjustments can be refined to further optimize outcomes. Building on our previous findings – where we demonstrated that both health (assessed via electrocochleography) cognitive function are key determinants CI (read here here) this...
Tonotopic cochlear organization underlies auditory perception, yet implant (CI) programming typically employs fixed frequency-place maps not based on human physiology. Animal studies suggest intensity-dependent shifts in tuning, but this has been confirmed humans. Here, we demonstrate that tonotopy dynamically basally with increasing sound intensity Using intracochlear electrocochleography from a 22-electrode array, found high-intensity stimuli (>80 dB SPL) shifted best-frequency locations...
Objective Assess the real-world performance of popular imputation algorithms on cochlear implant (CI) candidate audiometric data. Methods 7,451 audiograms from patients undergoing CI candidacy evaluation were pooled 32 institutions with complete case analysis yielding 1,304 audiograms. Imputation model was assessed nested cross-validation randomly generated sparse datasets various amounts missing data, distributions sparsity, and dataset sizes. A threshold for safe defined as root mean...
Objective To evaluate the impact of preoperative and perioperative factors on postlinguistic adult cochlear implant (CI) performance design a multivariate prediction model. Study Design Prospective cohort study. Setting Tertiary referral center. Patients Interventions Two hundred thirty-nine CI recipients. Main Outcome Measure(s) Speech-perception testing (consonant-nucleus-consonant [CNC], AzBio in noise +10-dB signal-to-noise ratio) at 3, 6, 12 months postoperatively;...
Primary amines can be readily doubly protected as N-substituted 2,5-dimethylpyrroles. Although this protecting group is stable toward strong bases and nucleophiles, long reaction times are required for both the protection deprotection steps, generally resulting in low yields. By employing microwave irradiation, dramatically reduced. Furthermore, with dilute hydrochloric acid ethanol increases Diverse conditions have been developed conjunction so that an 2,5-dimethylpyrrole orthogonal to...
Studies comparing perioperative outcomes of fibula free flaps (FFFs), osteocutaneous radial forearm (OCRFFFs), and scapula (SFFs) have been limited by insufficient sample size.To compare the patients who underwent FFFs, OCRFFFs, SFFs.This cohort study assessed 1022 or SFFs for head neck reconstruction performed at 1 6 academic medical centers between January 2005 December 2019. Data were analyzed from September 17, 2021, to June 9, 2022.Patients stratified based on flap performed. Evaluated...
Objective This study aimed 1) to measure the effect of cochlear implantation on health-related quality life (HR-QOL) using Cochlear Implant Quality Life (CIQOL) questionnaire and 2) determine audiologic, demographic, non-CI/hearing-related QOL factors influencing CIQOL. Study Design Prospective observational study. Setting Tertiary referral center. Patients Interventions Thirty-seven adult patients with sensorineural hearing loss undergoing implantation. Main Outcome Measure(s) CIQOL-global...
Objectives/Hypothesis To determine the frequency and management of short‐ long‐term complications related to oromandibular free flap reconstruction identify potentially predictive factors hardware complications. Study Design Retrospective chart review. Methods A retrospective database from review was formed consisting 266 reconstructions performed at a single institution over 15‐year period. Data were collected on demographics, surgical treatment, complications, Subgroup univariate...