A5072335900- Head and Neck Cancer Studies
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Research Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Reconstructive Surgery and Microvascular Techniques
- Head and Neck Surgical Oncology
- Cancer Diagnosis and Treatment
- Colorectal and Anal Carcinomas
- Lung Cancer Treatments and Mutations
- Lymphoma Diagnosis and Treatment
- Ear and Head Tumors
- Botany and Geology in Latin America and Caribbean
- Intensive Care Unit Cognitive Disorders
- Medical Imaging and Analysis
- Immunotherapy and Immune Responses
- Vascular Malformations and Hemangiomas
- Surgical Simulation and Training
- Nerve Injury and Rehabilitation
- interferon and immune responses
- Environmental and Cultural Studies in Latin America and Beyond
- Hearing Loss and Rehabilitation
- Sinusitis and nasal conditions
- Acute Lymphoblastic Leukemia research
- Bone fractures and treatments
- Respiratory and Cough-Related Research
Thomas Jefferson University Hospital
2024-2025
Thomas Jefferson University
2024-2025
Sidney Kimmel Cancer Center
2024
Johnson University
2021-2022
Rutgers, The State University of New Jersey
2021-2022
Universidad de Playa Ancha de Ciencias de la Educación
2022
Importance For patients treated with immune checkpoint inhibitors (ICIs), recent data suggest that obesity has a beneficial effect on survival outcomes in various cancer types. Reports this association head and neck are limited. Objectives To compare overall (OS) to 5 years functional squamous cell carcinoma (HNSCC) ICIs based pretreatment body mass index (BMI). Design, Setting, Participants This retrospective population-based cohort study used obtained from the TriNetX Global Collaborative...
Flow-through flaps (FTFs) are an advanced technique in which a free flap is anastomosed to the pedicle of another reconstruct extensive head and neck defects when recipient vessels scarce.
<p>Supplementary Appendix</p>
<p>Supplement Figure 1: Waterfall Plots. A: Degree of pathologic treatment response (pTR) at the lymph nodes. B: primary site, stratifed by arm. C: RECIST tumor site (yellow) and nodes (purple), arm.</p>
<div>AbstractPurpose:<p>We evaluated whether indoleamine 2,3-dioxygenase (IDO1) inhibitor (IDOi) BMS986205 + PD-1 nivolumab enhanced T-cell activity and augmented immune-mediated antitumor responses in untreated, resectable head neck squamous cell carcinoma (HNSCC). We employed response-adaptive surgical timing to identify responders immunotherapy enhance their response.</p>Patients Methods:<p>Patients with HNSCC were 3:1 randomized receive or without orally daily...
<p>Supplement Figure 4: STRING Networks enlarged. The networks of B cell (A) and CAF (B) as visualized in 5.</p>
<p>Supplement Figure 3: Signature-based Biomarkers. A: Signature-Based biomarkers for HPV negative patients. B: positive ‘Primary Path Response’ refers to analysis based on the pTR at primary site alone. ‘Overall path response’ + lymph node response.</p>
<p>Supplementary Figure 2: Effect of IDO inhibitor BMS986205 on response rate and the tryptophan kynurenine pathway. A B: IDO1 gene expression levels pathway activity score, respectively, compared between baseline samples responders (R) non-responders (NR) nivolumab + nivolumab-only therapies. C: Tryptophan score post-treatment R NR - ns, *p < 0.05, **p 0.01, ***p 0.001.</p>
Background: Sinonasal malignancy makes up a small subset of head and neck cancers. Prognosis for this disease can vary depending on the pathology location tumor. The mainstay treatment these malignancies includes surgical resection with adjuvant radiotherapy or chemotherapy if necessary. It is unknown age plays role in increasing risk developing complications following resection. We aim to analyze impact systemic outcomes sinonasal including cranial base utilizing large national database.
Objective Exploring whether the utilization of implantable hearing rehabilitation devices is associated with a reduced likelihood developing delirium in patients loss. Study Design A retrospective cohort database study propensity score matching (PSM) utilizing TriNetX clinical database. Setting The US Collaborative Network within (100 million people). Patients over 55 years old were selected based on three categories: non–hearing loss control (ICD-10: H90–91), (HL without device), and an...
Studies comparing perioperative outcomes of fibula free flaps (FFFs), osteocutaneous radial forearm (OCRFFFs), and scapula (SFFs) have been limited by insufficient sample size.To compare the patients who underwent FFFs, OCRFFFs, SFFs.This cohort study assessed 1022 or SFFs for head neck reconstruction performed at 1 6 academic medical centers between January 2005 December 2019. Data were analyzed from September 17, 2021, to June 9, 2022.Patients stratified based on flap performed. Evaluated...
Abstract Purpose: We evaluated whether IDO-inhibitor BMS986205 (IDOi) + PD-1 inhibitor nivolumab enhanced T-cell activity and augmented immune-mediated antitumor responses in untreated, resectable HNSCC. employed response-adaptive surgical timing to identify responders immunotherapy enhance their response. Patients Methods: with HNSCC were 3:1 randomized receive or without PO daily (NCT03854032). In the combination arm, was initiated 7 days prior nivolumab. stratified by HPV status....
(1) To compare perioperative outcomes and overall survival of patients with oropharyngeal salivary gland malignancies (OPSGMs) treated transoral robotic surgery (TORS) versus other approaches. (2) identify clinical factors associated a surgical approach.Retrospective analysis the National Cancer Database (NCDB).NCDB.Data obtained from NCDB were analyzed between 2010 2017 for T1-T4a OPSGMs without distant metastases surgically. Patients stratified by approach (TORS vs nonrobotic),...
Abstract Introduction: In recent years, immune checkpoint inhibitors (ICI) have revolutionized the landscape of treatment across a variety cancers. Potential concerns regarding racial disparities in ICI access and therapeutic efficacy been well documented. Recent studies indicated improved response outcomes White patients compared to minority groups with head neck cancer (HNC) melanoma patients. contrast, diagnosed lung mixed, some research suggesting black may fare better therapy. Existing...
Abstract Purpose: Liquid biopsy approaches are revolutionizing cancer monitoring and have been considered potential mediators for therapeutic efficacy in multiple cancers. The investigation of different liquid biomarkers may lead to a better understanding the cancers they designed detect facilitate optimal management. This study aimed identify compare epigenomic genomic profiles tumor circulation using cell-free DNA (cfDNA) exosomal (exoDNA) plasma saliva samples collected from patients with...
PURPOSE The levels of inflammatory blood markers, such as neutrophils, platelets, monocytes, and lymphocytes, can be informative for several cancer prognoses. However, the changes in other markers may additional sources prognostic information recurrence survival. In this study, we aim to investigate predictive value non-inflammatory HNSCC outcomes. METHOD a retrospective cohort 522 primary patients diagnosed between July 2010 March 2023 were included. Clinicopathological characteristics...
ABSTRACT Background Vessel grafting is an important technique in head and neck free tissue transfer (FTT) reconstruction when a tension‐free anastomosis not otherwise feasible. To our knowledge, there are limited data regarding interposition artery grafts for arterial anastomoses reconstruction. Here, we present multi‐institutional cohort of FTT defects. Methods A retrospective review was conducted at four tertiary care institutions patients who underwent defects which utilized graft the...
Tumors involving the vagus nerve are often clinically silent. We offer a case series with different clinical presentations and distinctive post-surgical sequelae that highlight some of challenges associated managing cervical vagal tumors.