A5101884534- PARP inhibition in cancer therapy
- Ovarian cancer diagnosis and treatment
- Advanced biosensing and bioanalysis techniques
- Peptidase Inhibition and Analysis
- Calcium signaling and nucleotide metabolism
- GDF15 and Related Biomarkers
- Molecular Biology Techniques and Applications
- MicroRNA in disease regulation
- Galectins and Cancer Biology
- Lymphoma Diagnosis and Treatment
- Advanced MRI Techniques and Applications
- Macrophage Migration Inhibitory Factor
- RNA Interference and Gene Delivery
- Toxin Mechanisms and Immunotoxins
- DNA Repair Mechanisms
- MRI in cancer diagnosis
- Retinal Development and Disorders
- Mesenchymal stem cell research
- RNA and protein synthesis mechanisms
- Chromatin Remodeling and Cancer
- Bacteriophages and microbial interactions
- Obstructive Sleep Apnea Research
- CRISPR and Genetic Engineering
- Immune Cell Function and Interaction
- DNA and Nucleic Acid Chemistry
University of Technology Sydney
2020-2024
Harbin Medical University
2024
Third Affiliated Hospital of Harbin Medical University
2024
First Affiliated Hospital of Bengbu Medical College
2024
Northwest A&F University
2023
First Hospital of China Medical University
2021
Xian Central Hospital
2021
Institute for Stem Cell Biology and Regenerative Medicine
2020
Wenzhou Medical University
2020
Affiliated Eye Hospital of Wenzhou Medical College
2020
Little is known about the gene expression profile and significance of rosetting CD4+CD26− T cells in classical Hodgkin's lymphoma (cHL). To characterize these cells, CD4+CD26+ T-cell populations were sorted from lymph node (LN) cell suspensions nodular sclerosis HL (NSHL) reactive LNs. mRNA profiles stimulated resting subsets evaluated with quantitative RT-PCR for 46 genes. We observed a higher percentage NSHL than The showed levels CD25, CTLA4, OX40 CCR4 compared LNs, supporting regulatory...
The microRNA cluster miR-183C, which includes miR-183 and two other genes, is critical for multiple sensory systems. In mouse retina, removal of this results in photoreceptor defects polarization, phototransduction, outer segment elongation. However, the individual roles three components are not clearly known. We studied separate role vivo.miR-183 knockout mice were generated using CRISPR/Cas9 genome-editing system. Electroretinography carried out to investigate changes retinal structures...
Abstract Introduction Mesenchymal stem cells (MSCs) are widely investigated in clinical researches to treat various diseases. Classic culture medium for MSCs, even use, contains fetal bovine serum. The serum-containing (SCM) seems a major obstacle MSCs-related therapies due the risk of contamination infectious pathogens. Some studies showed that MSCs could be expanded serum free (SFM); however, whether SFM would change biological characteristics and safety issues has not been well answered....
Hypoglycemia can potentially cause severe damage to the central nervous system. The ketogenic diet (KD), characterized by high-fat and extremely low-carbohydrate content, modulate homeostasis nutrient metabolism, thereby influencing body health. However, effects underlying mechanisms of KD on hypoglycemia-induced brain injury have not been thoroughly investigated. We aimed explore modulating cognitive functions elucidate mechanisms. In this study, one-month-old mice were fed with for 2...
Several poly (adenosine diphosphate-ribose) polymerase (PARP) inhibitors are now in clinical use for tumours with defects BReast CAncer genes
Abstract Engineering single base edits using CRISPR technology including specific deaminases and single-guide RNA (sgRNA) is a rapidly evolving field. Different types of can be constructed, with cytidine editors (CBEs) facilitating transition C-to-T variants, adenine (ABEs) enabling A-to-G C-to-G transversion (CGBEs) recently (AYBE) that create A-to-C A-to-T variants. The base-editing machine learning algorithm BE-Hive predicts which sgRNA editor combinations have the strongest likelihood...
To explore benefits of high-frame-rate contrast-enhanced ultrasonography (H-CEUS) for early kidney injury in a rabbit model diabetic nephropathy (DN).
Abstract Ovarian clear cell carcinoma (OCCC) is a difficult to treat histological subtype of ovarian cancer, demonstrating resistance standard chemotherapy. New approaches are required in order identify compounds with the potential target this tumor. OCCC characterized by mutations ARID1A and/or ARID1B (AT-rich interactive domain-containing proteins) that encode for members mammalian SWI/SNF (SWItch/Sucrose Non-Fermentable) chromatin remodeling complex. We have used an epigenetic library...
Background: Estrogen and progesterone are closely related to the occurrence of diabetes, progestogenic estrogenic effects in development diabetes their blood levels organism state, it is not clear what effect combination will be. The present study was investigate interaction between estrogen mellitus. Methods: A model type 1 mellitus（T1DM）was established ovariectomized (OVX) mice by intraperitoneal injection streptozotocin (STZ), plasma glucose, insulin, C-peptide, progesterone, estradiol,...
Abstract Background Postoperative delirium (POD) often occurs in oncology patients, further increasing the medical and financial burden. Robotic technology lower abdominal tumors resection reduces surgical trauma but increases risks such as carbon dioxide (CO 2 ) absorption. This study aimed to investigate differences their occurrence of POD at different end-tidal CO levels. Method was approved by Ethics Committee Affiliated Hospital He Bei University (HDFY-LL-2022-169). The registered with...