A5047894639- Rheumatoid Arthritis Research and Therapies
- Biochemical and Molecular Research
- Autoimmune and Inflammatory Disorders Research
- Hepatitis C virus research
- Metabolomics and Mass Spectrometry Studies
- Gout, Hyperuricemia, Uric Acid
- Inflammasome and immune disorders
- Bone Metabolism and Diseases
- Bone health and treatments
- Systemic Lupus Erythematosus Research
- Monoclonal and Polyclonal Antibodies Research
- Metabolism and Genetic Disorders
- Spondyloarthritis Studies and Treatments
- Osteoarthritis Treatment and Mechanisms
- Traditional Chinese Medicine Studies
- Lipid metabolism and disorders
- Vitamin D Research Studies
- Gut microbiota and health
- Lysosomal Storage Disorders Research
- Helicobacter pylori-related gastroenterology studies
- Vitamin C and Antioxidants Research
- Inflammation biomarkers and pathways
- Ginseng Biological Effects and Applications
- IL-33, ST2, and ILC Pathways
- Cellular transport and secretion
University of California, San Diego
2020-2025
Université Bourgogne Franche-Comté
2025
Universidad de Guadalajara
2016-2017
Hospital de Especialidades
2016-2017
Mexican Social Security Institute
2016-2017
Monosodium urate crystals (MSUc) induce inflammation in vivo without prior priming, raising the possibility of an initial cell-autonomous phase. Here, using genome-wide transcriptomic analysis and biochemical assays, we demonstrate that MSUc alone a metabolic-inflammatory transcriptional program non-primed human murine macrophages is markedly distinct to induced by LPS. Genes uniquely upregulated response belong lipid amino acid metabolism, glycolysis, SLC transporters. This upregulation...
Since previous studies indicate that metabolism is altered in rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS), we undertook this study to determine if changes the genome-wide chromatin and DNA states genes associated with nutrient transporters could help identify activated metabolic pathways RA FLS.
Abstract Background Synovial fibroblasts in rheumatoid arthritis (RAFLS) exhibit a pathological aberration of glycolysis and glutaminolysis. Henceforth, we aimed to investigate if dual inhibition these pathways by phytobiological compound c28MS has the potential synergistic therapy for targeting both glucose glutamine metabolism. Methods The presence HK2 GLS across various cell types associated gene expression human synovial cells murine model was evaluated scRNA-seq. metabolic profiling...
Tumor necrosis factor (TNF) is a pleiotropic cytokine that plays critical role in the pathogenesis of immune-mediated diseases including inflammatory bowel disease (IBD). The stability its mRNA transcript, determined part by destabilizing sequences AAUU repeats (ARE) gene region, an important regulator tissue and systemic levels. A deletion ARE region resulted IBD arthritis mice pigs, supporting for human several arthritides. mutation same area mouse genome Genentech scientists (T.Y., M.K.)...
Alterations in the levels of serum sphingolipids and phospholipids have been reported Gaucher disease Parkinson's disease, suggesting a potential role these lipids as biomarkers. This project's objective is to detect novel associations candidate biomarkers largest Spanish Parkinson diseases Iberian Peninsula. For that, 278 participants were included: 100 sporadic patients, 70 15 GBA1-mutation-carrier patients 93 controls. A lipidomics array including 10 phospholipid groups, 368 species, was...
Inflammatory responses are associated with changes in tissue metabolism. Prior studies find altered metabolomic profiles both the synovial fluid (SF) and serum of osteoarthritis subjects. Our study determined profile (ST) SF individuals (OA) its association inflammation.
Abstract Myostatin is a cytokine produced and released by myocytes that might have an outstanding role not only in muscle wasting during cachexia but also inflammation. Herein we explore the association between myostatin levels inflammatory parameters rheumatoid arthritis (RA). One hundred twenty-seven women without rheumatic diseases 84 with diagnosis of RA were assessed cross-sectional study. Outcomes reflecting activity including Disease Activity Score (DAS28-ESR) impairment functioning...
Osteoporosis (OP) is highly prevalent in rheumatoid arthritis (RA) and influenced by genetic factors. Single-nucleotide polymorphism (SNP) rs2073618 the TNFRSF11B osteoprotegerin ( OPG ) gene has been related to postmenopausal OP although, date, no information described concerning whether this implied abnormalities of bone mineral density (BMD) RA. We evaluated, a case-control study performed Mexican-Mestizo women with RA, SNP associated decrease BMD. RA patients were classified as follows:...
The analysis of metabolite mediators has allowed a broader understanding disease mechanisms. Experimental evidence indicates that metabolic rewiring is key feature inflammatory cells to restore tissue homeostasis upon damage. Over the last two decades, next-generation sequencing techniques have offered possibility looking at genome-wide effect exposure external stimuli. During gout flares, monosodium urate crystals activate distinct profile and transcriptional program in cells. extracellular...
Objective . To evaluate the association of -174G/C IL-6 polymorphism with failure in therapeutic response to methotrexate (MTX) or leflunomide (LEF). This prospective, observational cohort included 96 Mexican-Mestizo patients moderate severe rheumatoid arthritis (RA), initiating MTX LEF, genotyped for by PCR-RFLP. Therapeutic was strictly defined: only if achieved remission low disease activity (DAS-28 < 3.2). Results Patients LEF had significant decrement DAS-28 (<mml:math...
Fracture risk assessment tool (FRAX) index was developed for estimating of the 10-year major or hip osteoporotic fracture. To date, there is insufficient information regarding correlation between FRAX and serum bone turnover markers (BTMs), such as soluble ligand receptor activator nuclear factor-κB (sRANKL), osteoprotegerin (OPG), other molecules related with secondary osteoporosis in rheumatoid arthritis (RA). Therefore, this study aimed at assessing levels sRANKL, OPG, sRANKL/OPG ratio,...
Several interleukin 6 gene (IL6) polymorphisms are implicated in susceptibility to rheumatoid arthritis (RA). It has not yet been established with certainty if these associated the severe radiographic damage observed some RA patients, particularly those development of joint bone ankylosis (JBA). The objective present study was evaluate association between hands and -174G/C -572G/C IL6 Mexican Mestizo people RA. adults long disease duration (>5 years) were classified into two groups according...
The objective of this study was to investigate the usefulness soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) in predicting short-term therapeutic response methotrexate (MTX) rheumatoid arthritis (RA). Patients with active RA, Disease Activity Score-28 joints (DAS-28) >3.2, starting oral MTX, were included. We measured at baseline, 3 and 6 mo: DAS-28, Health Assessment Questionnaire–Disability Index (HAQ-DI), patient’s perception disease severity, morning stiffness...
There is limited information about the factors related with development of long-term permanent work disability (PWD) in rheumatoid arthritis (RA) treated a combination conventional synthetic disease-modifying antirheumatic drugs (cs-DMARDs).The aim this study was to evaluate incidence and associated PWD RA therapy using cs-DMARDs.We assessed multivariate models effect clinical demographic retrospective cohort 180 workers who were cs-DMARDs.Incidence rates 2.2% at 1 year, 7.7% 5 years, 24.9%...
Oxylipins are bioactive lipids derived from polyunsaturated fatty acids (PUFAs) that modulate inflammation and may remain overexpressed in refractory synovitis. In plasma, they could also be biomarkers of synovial pathology. The aim this study is to determine if oxylipins inflamed joints correlate with plasma histologic patterns.
The goal of the present study was to determine whether peptidylarginine deiminase PAD2 and PAD4 enzymes are in Balb/c mouse salivary glands they able citrullinate Ro La ribonucleoproteins. Salivary from mice were cultured DMEM supplemented with one following stimulants: ATP, LPS, TNF, IFN γ , or IL-6. A control group without stimulant also evaluated. PAD2, PAD4, citrullinated peptides, Ro60, detected by immunohistochemistry double immunofluorescence. mRNAs protein expression qPCR Western...