A5068169323- Carbohydrate Chemistry and Synthesis
- Glycosylation and Glycoproteins Research
- Animal Virus Infections Studies
- interferon and immune responses
- Cytomegalovirus and herpesvirus research
- Biochemical Analysis and Sensing Techniques
- Biochemical and Molecular Research
- Viral gastroenteritis research and epidemiology
- Cellular transport and secretion
- Virus-based gene therapy research
- Synthesis of Organic Compounds
- Antifungal resistance and susceptibility
- Lysosomal Storage Disorders Research
- Calcium signaling and nucleotide metabolism
- Hepatitis B Virus Studies
- Sphingolipid Metabolism and Signaling
Institute of Chemistry of the Slovak Academy of Sciences
2016-2025
Slovak Academy of Sciences
2016-2025
Biomedical Research Center of the Slovak Academy of Sciences
2023
Inhibition of the biosynthesis complex N-glycans in Golgi apparatus influences progress tumor growth and metastasis. α-mannosidase II (GMII) has become a therapeutic target for drugs with anticancer activities. One critical task successful application GMII medical treatments is to decrease their unwanted co-inhibition lysosomal (LMan), weakness all known potent inhibitors. A series novel N-substituted polyhydroxypyrrolidines was synthesized tested modeled GH38 α-mannosidases from Drosophila...
Enzymatic assays, molecular modeling and NMR studies of novel 1,4-dideoxy-1,4-imino-<sc>l</sc>-lyxitols provided new information on the GH38 family enzyme inhibitors their selectivity.