A5030427905- Eosinophilic Esophagitis
- Eosinophilic Disorders and Syndromes
- Obesity and Health Practices
- Bariatric Surgery and Outcomes
- IL-33, ST2, and ILC Pathways
- Neurobiology of Language and Bilingualism
- Obesity, Physical Activity, Diet
- Immune cells in cancer
- Cutaneous Melanoma Detection and Management
- Language Development and Disorders
- Breast Cancer Treatment Studies
- Atherosclerosis and Cardiovascular Diseases
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Patient-Provider Communication in Healthcare
- Health Literacy and Information Accessibility
- Tumors and Oncological Cases
- Anatomy and Medical Technology
- Digital Mental Health Interventions
- Multiple and Secondary Primary Cancers
- Male Reproductive Health Studies
- Monoclonal and Polyclonal Antibodies Research
- Nonmelanoma Skin Cancer Studies
- Exercise and Physiological Responses
- Williams Syndrome Research
- Mobile Health and mHealth Applications
Rush University Medical Center
2023-2025
Rush University
2023
Eastern Virginia Medical School
2002-2023
Cincinnati Children's Hospital Medical Center
2004-2023
University of Cincinnati
2006-2008
University of Alabama at Birmingham
1999-2007
Children's Hospital of The King's Daughters
2003
To determine the incidence of obstructive sleep apnea syndrome in children aged 2 to 4 years with Down and parents' ability predict abnormalities this patient population.Prospective cohort study.Tertiary care pediatric referral center.Sixty-five participating a 5-year longitudinal study which otolaryngologic problems seen were evaluated. Fifty-six completed overnight polysomnography (PSG) between 63 months age (mean age, 42 months).Overnight PSG was performed. Parents also questionnaire...
De novo mutations (DNMs), or that appear in an individual despite not being seen their parents, are important source of genetic variation whose impact is relevant to studies human evolution, genetics, and disease. Utilizing high-coverage whole-genome sequencing data as part the Trans-Omics for Precision Medicine (TOPMed) Program, we called 93,325 single-nucleotide DNMs across 1,465 trios from array diverse populations, used them directly estimate analyze DNM counts, rates, spectra. We find a...
Pediatric eosinophilic esophagitis (EE) is a recently described disorder associated with atopy. Although studies of esophageal tissue suggest that Th2 cytokines and eotaxin-3 may be crucial in disease pathogenesis, little known about the systemic immunological phenotypes children EE.To define peripheral blood eosinophils lymphocytes EE to examine for correlations between these parameters eosinophil numbers severity.Blood was collected from EE, atopic control without nonatopic EE. Flow...
The aim of this study was to examine the Autism Diagnostic Observation Schedule (ADOS) as it is commonly used in clinical practice. ADOS classifications were compared final diagnoses given by a multidisciplinary team 584 children referred for evaluation possible autism spectrum disorder (ASD) at Cincinnati Children's Hospital Medical Center. A total 177 evaluated with Module 1 (87 No Words), 198 2 (90 < 5 years) and 209 3. Of these, 142 (26%) diagnosed autism, 185 (32%) non-autism ASD, 257...
Congenital heart disease (CHD) is the most common major congenital anomaly and causes significant morbidity mortality. Epidemiologic evidence supports a role of genetics in development CHD. Genetic diagnoses can inform prognosis clinical management. However, genetic testing not standardized among individuals with We sought to develop list validated CHD genes using established methods evaluate process returning results research participants large genomic study.
Objective. To determine 1) the electronic mail (e-mail) capabilities of families, general pediatricians (GPs), and subspecialty (SPs) from an integrated pediatric health care delivery system 2) knowledge base attitudes these groups regarding potential issues involved in using e-mail for physician-patient communication. Methods. Parents were interviewed offices participating practices a standardized survey tool. Pediatricians staff separate instrument. The data entered into database analysis....
In this 2000–2001 study, the authors compared effectiveness of male latex condom and female polyurethane by assessing frequency types mechanical failure evaluating semen exposure during use. Eligible women from Birmingham, Alabama, were randomly assigned to begin study with 10 condoms then switch (n = 55), or vice versa 53), trained use both types. Data collection included questionnaires for each measurement prostate-specific antigen in specimens vaginal fluid taken before after intercourse....
Preschool-aged children with speech-sound disorders may be at risk for associated deficits in fine motor function. The objectives of this study were 2-fold: (1) to determine whether abnormalities function could detected 2- 5-year-old and (2) there was a correlation between abnormal oral-motor imitation skills Thirty-two (6 female, 26 male) prospectively evaluated from July 2003 2005, the Peabody Developmental Motor Scales Kaufman Speech Praxis Test Children administered. presence as measured...
Speech-sound disorders are common in preschool-age children, and characterized by difficulty the planning production of speech sounds their combination into words sentences. The objective this study was to review compare results Sensory Profile () children with a specific type speech-sound disorder, childhood apraxia (CAS), explore relationship between sensory processing sound-production deficits. Participants were identified prospectively through an interdisciplinary clinic at tertiary care...
Although there are well-established clinical human milk banks in the United States, no specifically intended to foster research on milk. The authors' goal was establish a bank with core data set support exploratory and hypothesis-driven studies Donations Cincinnati Children's Research Human Milk Bank accepted within context of ongoing, or an ad hoc basis. Donors must give informed consent, scientists wishing use samples have Institutional review board approval for their use. Development more...
Neutrophils drive atheroprogression and directly contribute to plaque instability. We recently identified signal transducer activator of transcription 4 (STAT4) as a critical component for bacterial host defense in neutrophils. The STAT4-dependent functions neutrophils atherogenesis are unknown. Therefore, we investigated contributory role STAT4 during advanced atherosclerosis.We generated myeloid-specific Stat4ΔLysMLdlr-/-, neutrophil-specific Stat4ΔS100A8Ldlr-/-, control Stat4fl/flLdlr-/-...
9578 Background: Several barriers to care exist for melanoma patients including distance specialty care, transportation, and cost. Additionally, differences in rural urban incidence have not been fully investigated. Using a large nationwide database, we aim investigate the relationship between locations stage of presentation access adjuvant systemic treatment. Methods: The National Cancer Database (NCDB) was queried all adult (≥ 18 years old) with diagnosis cutaneous from 1/1/2011 –...