A5055008538- Pneumonia and Respiratory Infections
- Emergency and Acute Care Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Delphi Technique in Research
- Nosocomial Infections in ICU
- Asthma and respiratory diseases
- Respiratory viral infections research
- Medical Imaging and Pathology Studies
- Lung Cancer Diagnosis and Treatment
- Pneumocystis jirovecii pneumonia detection and treatment
- COVID-19 Clinical Research Studies
- COVID-19 and healthcare impacts
- Sepsis Diagnosis and Treatment
- Long-Term Effects of COVID-19
- Chronic Disease Management Strategies
- Health Systems, Economic Evaluations, Quality of Life
- Malaria Research and Control
- Meta-analysis and systematic reviews
- Pediatric health and respiratory diseases
- Pleural and Pulmonary Diseases
- Hepatocellular Carcinoma Treatment and Prognosis
- Congenital Diaphragmatic Hernia Studies
- Clinical practice guidelines implementation
- Neonatal Respiratory Health Research
- Viral Infections and Vectors
Frederiksberg Hospital
2021-2025
Copenhagen University Hospital
2015-2025
University of Copenhagen
2025
European Respiratory Society
2021-2024
Danish Medical Association
2024
Gentofte Hospital
2018-2022
Herlev Hospital
2021
Nordsjællands Hospital
2021
Zealand University Hospital
2019
Bispebjerg Hospital
2015-2016
Background In patients with interstitial lung diseases (ILD), histopathological input is often required to obtain a diagnosis. Surgical biopsy (SLB) considered the reference standard, but many are clinically unfit undergo this invasive procedure, and adverse events, length of hospitalisation costs considerable. This European Respiratory Society (ERS) guideline provides evidence-based clinical practice recommendations for role transbronchial cryobiopsy (TBLC) in obtaining tissue-based...
Background: This study was conducted to investigate whether point-of-care (POC) procalcitonin (PCT) measurement can reduce redundant antibiotic treatment in patients hospitalized with acute exacerbation of COPD (AECOPD). Methods: One-hundred and twenty adult admitted AECOPD were enrolled this open-label randomized trial. Patients allocated either the POC PCT-guided intervention arm (n=62) or control arm, which therapy followed local guidelines (n=58). Results: The median duration exposure...
The use of direct nested PCR enables the detection Plasmodium spp. from blood samples collected on filter papers without requiring time-consuming procedures associated with DNA extraction. Direct provides a rapid, highly sensitive, and cost-effective alternative to diagnosing malaria using paper standard PCR.
Inhaled corticosteroids (ICS) can improve clinical outcomes in patients with chronic obstructive pulmonary disease (COPD) and eosinophilic airway inflammation, but they also increase the risk of side effects like pneumonia. Blood eosinophils guide ICS use, though evidence is limited. The predictors treatment REsponse to COPD: a randomised controlled trials (RCTs) individual participant Data re-Evaluation (ICS-RECODE) research programme will leverage data from large RCTs identify who benefit...
Introduction Airway management describes a range of commonly performed procedures undertaken to enable invasive respiratory support for patients. Studies airway interventions report heterogeneous outcomes, impeding evidence synthesis and translation findings into clinical practice. A core outcome set is consensus-based standardised minimum collection outcomes be reported in given area healthcare. The Terminology Outcome Measures project aims define select measurement instruments future...
Objective Recent reports indicate that first cases of genuine artemisinin resistance have already emerged along the Thai-Cambodian border. The main objective this trial was to track potential emergence in Bangladesh, which terms drug forms a gateway Indian subcontinent. Methods We conducted an open-label, randomized, controlled 42-day clinical Southeastern Bangladesh investigate spread from Southeast Asia. A total 126 uncomplicated falciparum malaria patients were randomized one 3 treatment...
ABSTRACT Background and objective Airway eosinophilia is associated with an increased risk of asthma exacerbations; however, the impact on severity exacerbations largely unknown. We describe sputum inflammatory phenotype during exacerbation correlate it treatment response. Methods Patients presenting to hospital were recruited a 12‐month period followed up after 4 weeks. Induced was collected at both visits. underwent spirometry, arterial blood gas analysis, fractional exhaled nitric oxide...
Markus Fallya* , Simone Israelsenb, Jacob Anhøjc, Thomas Benfieldb, Britta Tarpd, Lilian Koltee & Pernille Ravnfa Department of Internal Medicine, Section for Pulmonary Diseases, Herlev Gentofte Hospital, Hellerup, Denmark; b Infectious Amager Hvidovre Hvidovre, c Centre Diagnostic Investigation, Rigshospitalet, Copenhagen, d Centre, Silkeborg Regional Silkeborg, e Respiratory Medicine and Nordsjællands Hillerød, f Supervisor Denmark
To inform clinical practice guidelines, randomized controlled trials (RCTs) of the management pneumonia need to address outcomes that are most important patients and health professionals using consistent instruments, enable results be compared, contrasted, combined as appropriate. This systematic review describes reported in instruments used measure these outcomes.
In malaria-endemic regions any febrile case is likely to be classified as malaria based on presumptive diagnosis largely caused by a lack of diagnostic resources. A district-wide prevalence study assessing etiologies fever in 659 patients recruited rural and semi-urban areas Bandarban district southeastern Bangladesh revealed high proportions seropositivity for selected infectious diseases (leptospirosis, typhoid fever) potentially being misdiagnosed because similarities the clinical...
To explore whether short-course antibiotic therapy is efficient and safe in routine clinical settings among patients hospitalized with community-acquired pneumonia (CAP) who achieve an early response.During 2017-2019, we conducted a cohort study of admitted CAP to four hospitals Denmark. Data were prospectively gathered from medical records enriched data nationwide registries. In the present study, included response divided them into treatment groups based on duration, as decided by...
Background Community-acquired pneumonia (CAP) is one of the leading causes healthcare utilisation and death worldwide. Treatment according to evidence-based clinical guidelines can reduce mortality, antibiotic exposure length hospital stay related CAP. Local problem Several studies, including a pilot study from our sites, indicate that physicians show low grade guideline adherence when managing patients with Methods To improve guideline-based treatment CAP admitted hospital, we designed...
It is crucial that randomized controlled trials (RCTs) on the management of coronavirus disease 2019 (COVID-19) evaluate outcomes are critical to patients and clinicians, facilitate relevance, interpretability, comparability. This methodological systematic review describes evaluated in 415 RCTs COVID-19, were registered with ClinicalTrials.gov, by 5 May 2020, instruments used measure these outcomes. Significant heterogeneity was observed selection instruments. Mortality, adverse events...
Ten questions to assess what degree a clinical practice guideline is likely be trustworthy: 1) Do the authors have conflicts of interests? 2) Is question relevant? 3) Have relevant stakeholders been involved? 4) methods for study selection described? 5) there link between evidence and recommendations (transparent methods)? 6) Has certainty assessed? 7) reaching 8) Are unambiguous? 9) in your situation? 10) an implementation strategy?
Liver biopsy using transesophageal bronchoscopic ultrasound-guided fine needle aspiration (EUS-B-FNA) has never been described before and biopsies of infradiaphragmatic lesions this technique are not considered to be standard. A patient suspected for primary lung cancer with multiple in the liver was referred our department. We conducted bronchoscopy endobronchial (EBUS) from several enlarged mediastinal lymph nodes. Thereafter, we EUS-B-FNA a lesion left lobe. Pathology showed that...
This study aimed to determine whether collecting a lower respiratory tract sample (LRTS) for bacterial microscopy, culture, and resistance (MCR) testing affects outcomes in patients with CAP.