A5047530636- Sleep and Wakefulness Research
- Sleep and related disorders
- Coffee research and impacts
- Adenosine and Purinergic Signaling
- EEG and Brain-Computer Interfaces
- Heart Rate Variability and Autonomic Control
- Diet and metabolism studies
- Advanced Chemical Sensor Technologies
- Cardiovascular Syncope and Autonomic Disorders
- Sleep and Work-Related Fatigue
- Respiratory and Cough-Related Research
- Stress Responses and Cortisol
- Tryptophan and brain disorders
- Nuclear Physics and Applications
- Radiomics and Machine Learning in Medical Imaging
- Circadian rhythm and melatonin
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Neuroscience and Neuropharmacology Research
- Medical Imaging Techniques and Applications
- Bipolar Disorder and Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience of respiration and sleep
University of Zurich
2019-2025
University Hospital of Zurich
2024-2025
Institute of Pharmacology
2022-2025
Sleep loss pervasively affects the human brain at multiple levels. Age-related changes in several sleep characteristics indicate that reduced quality is a frequent characteristic of aging. Conversely, disruption may accelerate aging process, yet it not known what will happen to age status if we can manipulate conditions. To tackle this question, used an approach investigate whether would cause age-related brain. We included MRI data 134 healthy volunteers (mean chronological 25.3 between 19...
Many people consume coffee to attenuate increased sleepiness and impaired vigilance attention due insufficient sleep. We investigated in genetically caffeine sensitive men women whether 'real world' consumption during a simulated busy work week counteracts disabling consequences of chronically restricted subjected homozygous C-allele carriers ADORA2A (gene encoding adenosine A2A receptors) five nights only 5 h time-in-bed. administered regular (n = 12; 200 mg at breakfast 100 after lunch)...
Abstract Introduction It has been shown that mood is disturbed by sleep restriction (SR). We examined how and sleepiness after SR are impacted the use of caffeinated coffee. Methods Data from 72 volunteers were assessed during 3 baseline 5 experimental (E1 to E5) days. The control group (n=15, 66.7% male, mean age ± SD 28.0 5.7) had 8 h time in bed (TIB) throughout study. (n=21, 57.1% 26.4 3.7), decaffeinated coffee (DECAFF, n=17, 58.8% 27.9 5.3) (CAFF, n=19, 57.9% 29.9 5.0) TIB at nights....
Abstract Aims The aim of this initial study was to explore whether prediction models based on breath metabolome profiles could detect differences between pulmonary vascular disease patients and healthy controls. Additionally, we sought investigate the potential distinguish two major subtypes disease—pulmonary arterial hypertension chronic thromboembolic hypertension—to support early detection targeted treatment. Methods Results We used real-time analysis compare with controls, those...
Summary Clinical guidelines recommend sodium oxybate (SXB; the salt of γ‐hydroxybutyrate) for treatment disturbed sleep and excessive daytime sleepiness in narcolepsy, yet underlying mode action is elusive. In a randomised controlled trial 20 healthy volunteers, we aimed at establishing neurochemical changes anterior cingulate cortex (ACC) following SXB‐enhanced sleep. The ACC core neural hub regulating vigilance humans. At 2:30 a.m., administered double‐blind cross‐over manner an oral dose...
Abstract Sleep inertia is a disabling state of grogginess and impaired vigilance immediately upon awakening. The adenosine receptor antagonist, caffeine, widely used to reduce sleep symptoms, yet the initial, most severe impairments are hardly alleviated by post-awakening caffeine intake. To ameliorate this more potently, we developed an innovative, delayed, pulsatile-release formulation targeting efficacious dose briefly before planned We comprehensively tested in two separate studies....
The neuromodulator adenosine and its receptors are mediators of sleep-wake regulation which is known to differ between sexes. We, therefore, investigated sex differences in A1 receptor (A1AR) availability healthy human subjects under well-rested conditions using [18F]CPFPX positron emission tomography (PET). PET scans were acquired 50 participants (20 females; mean age ± SD 28.0 5.3 years). Mean binding potential (BPND; Logan's reference tissue model with cerebellum as region) volume...
Abstract Background Gamma-hydroxybutyrate (GHB; or sodium oxybate) is an endogenous GHB-/gamma-aminobutyric acid B receptor agonist. It approved for application in narcolepsy and has been proposed the potential treatment of Alzheimer’s disease, Parkinson’s fibromyalgia, depression, all which involve neuro-immunological processes. Tryptophan catabolites (TRYCATs), cortisol-awakening response (CAR), brain-derived neurotrophic factor (BDNF) have suggested as peripheral biomarkers...
Acute caffeine intake affects brain and cardiovascular physiology, yet the concentration-effect relationships on electroencephalogram cardiac autonomic activity during sleep are poorly understood. To tackle this question, we simultaneously quantified plasma concentration with ultra-high-performance liquid chromatography, as well electroencephalogram, heart rate high-frequency (0.15-0.4 Hz) spectral power in variability, representing parasympathetic activity, standard polysomnography...
The EEG alpha rhythm (∼ 8-13 Hz) is one of the most salient human brain activity rhythms, modulated by level attention and vigilance related to cerebral energy metabolism. Spectral power in range wakefulness sleep strongly varies among individuals based on genetic predisposition. Knowledge about underlying genes scarce, yet small studies indicated that variant rs5751876 gene encoding A2A adenosine receptors (ADORA2A) may contribute inter-individual variation. neuromodulator directly linked...
Evidence has shown that both sleep loss and daily caffeine intake can induce changes in grey matter (GM). Caffeine is frequently used to combat sleepiness impaired performance caused by insufficient sleep. It unclear (1) whether use of could prevent or exacerbate the GM alterations induced 5-day restriction (i.e. chronic restriction, CSR), (2) potential impact on plasticity depends individual differences availability adenosine receptors, which are involved mediating effects waking function....
Motivation: We developed a deep learning model to enhance the image quality of ultra-low dose brain PET. Goal(s): Significantly reducing injected not only minimizes radiation risk in subjects but also provides options for scanning protocols, and more follow-up studies. Approach: proposed 3D-Residual Attention U-Net initially trained on whole-body [18F]FDG PET/MR images. used transfer approach fine-tune our [18F]CPFPX PET/MRI inhouse dataset. Results: achieved improved metrics compared with...
Abstract BACKGROUND AND OBJECTIVE
Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) show high variability in
individual susceptibility and promote progression; thus, accurate diagnosis treatment is
essential. Unravelling the molecular metabolic changes during AECOPD in breath could promote
understanding its treatment. Our objective was to investigate breath
profiles for biomarker detection.
METHODS
We conducted...
Abstract The EEG alpha rhythm (8-13 Hz) is one of the most salient human brain activity rhythms. Spectral power in range wakefulness and sleep varies among individuals based on genetical predisposition, yet knowledge about underlying genes scarce. oscillations are related to cerebral energy metabolism modulated by level attention vigilance. neuromodulator adenosine directly linked as product tri-phosphate (ATP) breakdown acts a promoting molecule activitating A 1 2A receptors. We quantified...
Abstract Evidence has shown that both sleep loss and daily caffeine intake can induce changes in grey matter (GM). Caffeine is frequently used to combat sleepiness impaired performance caused by insufficient sleep. It unclear 1) whether use of could prevent or exacerbate the GM alterations induced chronic restriction, 2) potential impact on plasticity depends individual differences availability adenosine receptors, which are involved mediating effects waking function. In this double-blind,...
Abstract Acute caffeine intake affects brain and cardiovascular physiology, yet the concentration-effect relationships on electroencephalogram (EEG) cardiac autonomic activity during sleep are poorly understood. To tackle this question, we simultaneously quantified plasma concentration with ultra-high-performance liquid chromatography, as well EEG, heart rate high-frequency (0.15-0.4 Hz) spectral power in variability (HR-HRV), representing parasympathetic activity, standard polysomnography...
Ziel/Aim The stimulating effects of commonly consumed caffeine, the major psychostimulant ingredient coffee, are evoked through non-selective antagonism at adenosine receptors. [F-18]CPFPX is a highly selective and affine ligand A1 receptor (A1AR) has been successfully implemented as PET ligand. Here, we quantified by in vivo brain occupancy A1AR after short-term coffee consumption during sleep restriction subsequent abstinence human brain.