A5060629331- Noise Effects and Management
- Vehicle Noise and Vibration Control
- Sleep and Work-Related Fatigue
- Sleep and related disorders
- Sleep and Wakefulness Research
- Hearing Loss and Rehabilitation
- Spaceflight effects on biology
- High Altitude and Hypoxia
- Neuroscience of respiration and sleep
- Acoustic Wave Phenomena Research
- Occupational Health and Performance
- EEG and Brain-Computer Interfaces
- Adenosine and Purinergic Signaling
- Human-Automation Interaction and Safety
- Heart Rate Variability and Autonomic Control
- Cardiovascular and Diving-Related Complications
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Aerospace and Aviation Technology
- Air Quality and Health Impacts
- Air Traffic Management and Optimization
- Impact of Light on Environment and Health
- Coffee research and impacts
- Neuroscience and Neuropharmacology Research
- Ergonomics and Musculoskeletal Disorders
- Circadian rhythm and melatonin
Deutsches Zentrum für Luft- und Raumfahrt e. V. (DLR)
2016-2025
RWTH Aachen University
2017-2025
Linde (Germany)
2007-2023
Institute of Air Handling and Refrigeration
2022
Traffic noise disturbs sleep and may impair recuperation. There is limited information on single combined effects of air, road, rail traffic recuperation.Repeated measures.Polysomnographic laboratory study.72 healthy subjects, mean ± standard deviation 40 13 years, range 18-71 32 male.Exposure to 40, 80, or 120 rail, and/or air events.Subjects were investigated for 11 consecutive nights, which included 8 exposure nights one noise-free control night. Noise structure continuity subtle, even in...
ABSTRACT Circadian clocks in the body drive daily cycles physiology and behavior. A master clock brain maintains synchrony with environmental day–night cycle uses internal signals to keep other tissues aligned. Work cell cultures uncovered cyclic changes tissue oxygenation that may serve reset synchronize circadian clocks. Here we show healthy humans, following a randomized controlled single‐blind counterbalanced crossover study design, one‐time exposure moderate ambient hypoxia (FiO 2 ~15%,...
Adenosine and functional A1 adenosine receptor (A1AR) availability are supposed to mediate sleep-wake regulation cognitive performance. We hypothesized that cerebral A1AR after an extended wake period decreases a well-rested state recovery sleep. [18F]CPFPX positron emission tomography was used quantify in 15 healthy male adults 52 h of sleep deprivation following 14 Data were additionally compared with values 8 baseline from earlier dataset. Polysomnography, performance, sleepiness...
Summary The metabotrophic subtype 5 glutamate receptor ( mG luR5) plays a critical role in synaptic plasticity besides its involvement numerous neurological disorders, such as depression. As luR5 availability humans is altered sleep deprivation, we hypothesized that underlies circadian variation. To investigate whether potential changes measured density randomized fashion at six different daytimes 11 adult Sprague–Dawley rats. was quantified by positron emission tomography PET ) using the...
Trait-like differences in cognitive performance after sleep loss put some individuals more at risk than others, the basis of such disparities remaining largely unknown. Similarly, interindividual impairment response to alcohol intake have been observed. We tested whether impairments due either acute or chronic can be predicted by an individual's vulnerability intake. Also, we used positron emission tomography (PET) test infusion results up-regulation cerebral A1 adenosine receptors (A1ARs),...
Sleep loss pervasively affects the human brain at multiple levels. Age-related changes in several sleep characteristics indicate that reduced quality is a frequent characteristic of aging. Conversely, disruption may accelerate aging process, yet it not known what will happen to age status if we can manipulate conditions. To tackle this question, used an approach investigate whether would cause age-related brain. We included MRI data 134 healthy volunteers (mean chronological 25.3 between 19...
Objectives: Air, road, and railway traffic, the three major sources of traffic noise, have been reported to differently impact on annoyance. However, these findings may not be transferable physiological reactions during sleep which are considered decrease nighttime recovery might mediate long-term negative health effects. Studies awakenings from indicate that while having least annoyance, most disturbing properties compared aircraft noise. This study presents a comparison between modes their...
Abstract The accumulation of chronic sleep deficits combined with acute loss is common in shift workers and increases the risk errors accidents. We investigated single effects recovery on working memory performance ( N ‐back task) overnight declarative recall (paired‐associate lists) 36 healthy participants. After baseline measurements, restriction group n = 21; mean [ SD ] age 26 [4] years) underwent 5 nights (5‐hr time bed [TIB]), whereas control 15; 28 [6] had 8‐hr TIB during those...
European regulations restrict the duration of maximum daily flight duty period for pilots as a function start time and number scheduled flights. However, late end times that may include long awake are not specifically regulated. In this study, fatigue levels in finishing their at night (00:00-01:59 hour) were analysed compared with starting early (05:00-06:59 hour). Fatigue 40 commercial short-haul studied during total 188 periods, which 87 started 22 finished late. Pilots used small...
Environmental noise exposure disturbs sleep and impairs recuperation, may contribute to the increased risk for (cardiovascular) disease. Noise policy regulation are usually based on average responses despite potentially large inter-individual differences in effects of traffic sleep. In this analysis, we investigated what percentage total variance noise-induced awakening reactions can be explained by stable differences. We 69 healthy subjects polysomnographically (mean ± standard deviation 40...
Abstract Sleep deprivation (SD) could amplify the temporal fluctuation of spontaneous brain activities that reflect different arousal levels using a dynamic functional connectivity (dFC) approach. Therefore, we intended to evaluate test–retest reliability dFC characteristics during rested wakefulness (RW), and explore how properties these states were affected by extended durations acute sleep loss (28/52 hr). We acquired resting‐state fMRI neuropsychological datasets in two independent...
Many people consume coffee to attenuate increased sleepiness and impaired vigilance attention due insufficient sleep. We investigated in genetically caffeine sensitive men women whether 'real world' consumption during a simulated busy work week counteracts disabling consequences of chronically restricted subjected homozygous C-allele carriers ADORA2A (gene encoding adenosine A2A receptors) five nights only 5 h time-in-bed. administered regular (n = 12; 200 mg at breakfast 100 after lunch)...
Abstract Study Objectives The psychomotor vigilance task (PVT) is a widely used objective method to measure sustained attention, but the standard 10-min version often impractical in operational settings. We investigated reliability and validity of 3-min PVT administered on portable handheld device assessing sensitivity sleep loss alcohol relation applied tasks. Methods A total 47 healthy volunteers underwent 12 consecutive days lab protocol. cross-over design was adopted including...
Abstract Aim Altered mitochondrial function across various tissues is a key determinant of spaceflight‐induced physical deconditioning. In comparison to tissue biopsies, blood cell bioenergetics holds promise as systemic and more readily accessible biomarker, which was evaluated during head‐down tilt bed rest (HDTBR), an established ground‐based analog for physiological changes in humans. More specifically, this study explored the effects HDTBR exercise countermeasure on respiration...
Abstract Introduction It has been shown that mood is disturbed by sleep restriction (SR). We examined how and sleepiness after SR are impacted the use of caffeinated coffee. Methods Data from 72 volunteers were assessed during 3 baseline 5 experimental (E1 to E5) days. The control group (n=15, 66.7% male, mean age ± SD 28.0 5.7) had 8 h time in bed (TIB) throughout study. (n=21, 57.1% 26.4 3.7), decaffeinated coffee (DECAFF, n=17, 58.8% 27.9 5.3) (CAFF, n=19, 57.9% 29.9 5.0) TIB at nights....
Abstract Introduction According to the synaptic homeostasis hypothesis, wakefulness will lead an increase in strength. Several lines of evidence indicate animals that markers strength during wake and decline sleep. Examples proxies are amount AMPA receptors, cortical spine density, number size synapses local field potential rising. Nevertheless, some in-vitro in-vivo studies reveal opposite results which may be due differences examined brain regions, layers or housing animals. Thus far,...
Zusammenfassung Untersucht wurde der kombinierte Einfluss von Alkohol und hypobarer Hypoxie auf Schlaf, Sauerstoffsättigung (SpO₂) Herzfrequenz. Zwei Gruppen verbrachten 2 4-stündige Nächte im Schlaflabor (n = 23; 53 m über dem Meeresspiegel) oder in Druckkammer 17; 753 hPa entsprechend 2438 Meeresspiegel, hypobare Bedingung). Vor einer beiden konsumierten die Teilnehmer*innen Alkohol, wobei Reihenfolge randomisiert war. Zwischen den Nächten lagen 8-stündige Erholungsnächte. Während wurden...
Railway noise interferes with daytime activities and disturbs sleep leading to annoyance of exposed residents. The main objective this paper was establish exposure-response relationships between nocturnal railway exposure examine self-reported disturbances as short-term reactions noise. In a field study 33 residents living close tracks in the Cologne/Bonn area (Germany) were investigated. measured indoors during nine consecutive nights at each site. Questionnaires referring non-acoustical...
Abstract Adenosine, its interacting A 1 and 2A receptors, particularly the variant rs5751876 in gene ADORA2A have been shown to modulate anxiety, arousal, sleep. In a pilot positron emission tomography (PET) study healthy male subjects, we suggested an effect of on vivo brain receptor (A AR) availability. As female sex adenosinergic/dopaminergic interaction partners might impact this AR availability, aimed (1) further investigate male-based findings independent, newly recruited cohort...