A5100448869- Diabetes Management and Research
- Diabetes Treatment and Management
- Diabetes Management and Education
- Pancreatic function and diabetes
- Pharmacological Effects of Natural Compounds
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiac Health and Mental Health
- Microbial Natural Products and Biosynthesis
- Cardiovascular Function and Risk Factors
- Ginseng Biological Effects and Applications
- Circular RNAs in diseases
- Natural Antidiabetic Agents Studies
- Bioactive Compounds and Antitumor Agents
- MicroRNA in disease regulation
- Natural product bioactivities and synthesis
- Cytokine Signaling Pathways and Interactions
- Chronic Disease Management Strategies
- Diabetes, Cardiovascular Risks, and Lipoproteins
Jining First People's Hospital
2019-2023
This study aims to evaluate the efficacy and therapeutic mechanism of bufalin on lung adenocarcinoma (LUAD) through a comprehensive strategy integrating network pharmacology, metabolomics molecular biology verification.The putative targets were discerned from PharmMapper Swiss Target Prediction database. LUAD-related obtained by target filtering GeneCard database data mining GEO PPI was constructed screen core targets, their clinical significance assessed several public databases. GO KEGG...
Notoginsenoside R1 (NGR1) is a major bioactive ingredient of Radix notoginseng that has promise in treating several diabetes-related diseases, like diabetic nephropathy and cardiomyopathy. This work designed to explore if NGR1 potential peripheral neuropathy (DPN). A cell model DPN was made by stimulating RSC96 cells with high glucose. The effects preconditioning were examined conducting CCK-8 assay, flow cytometry, ROS assay Western blot. downstream effector signalling then explored qRT-PCR...
To explore facilitators and barriers to self-management engagement of Chinese people with poorly controlled type 2 diabetes.Purposive sampling method was used for recruitment. Semi-structured interview thematic analysis data collection analysis.Twenty-six semi-structured interviews were conducted. Poor blood glucose control introduced awareness susceptibility complications, while mental disorders could be concomitant. General knowledge about healthy lifestyle unhealthy habits impeded...
Presently, insulin resistance has been a growing concern that urgently needs to be addressed, because it not only places patients at risk of developing type 2 diabetes mellitus but also results in metabolic syndrome and different aspects cardiovascular diseases. Shenqi Jiangtang Granule (SJG) is classic traditional Chinese medicine (TCM) prescription widely used treat its complications clinical practice. While studies have revealed SJG with multi-ingredients multi-targets characteristics...
Abstract Background Patients with type 2 diabetes mellitus (T2DM) usually have higher blood viscosity attributed to high glucose that can decrease supply the pancreas. A mild increase in pressure (BP) has been reported as a potential compensatory response maintain perfusion islet. However, how BP influences beta-cell function T2DM subjects remains inconsistent. This study aimed examine relationship between and patients under different HbA1c levels. Methods is cross-sectional of 615 patients,...
Abstract Background: Blood glucose is poorly controlled and self-management engagement inadequate in Chinese people with type 2 diabetes. This study aimed to explore facilitators barriers of Methods: Patients wit diabetes were recruited from National Metabolic Management Center. Purposive sampling method was used for recruitment. Semi-structured interview thematic analysis data collection analysis. Results: 26 semi-structured interviews conducted. Poor blood increased awareness...
To examine whether the different patterns of post-load insulin secretion can identify heterogeneity type 2 diabetes mellitus (T2DM).Six hundred twenty-five inpatients with T2DM at Jining No. 1 People's Hospital were recruited from January 2019 to October 2021. The 140 g steamed bread meal test (SBMT) was conducted on patients T2DM, and glucose, insulin, C-peptide levels recorded 0, 60, 120, 180 min. avoid effect exogenous categorized into three classes by latent class trajectory analysis...
To assess whether the beta-cell function of inpatients undergoing antidiabetic treatment influences achieving time in range (TIR) and above (TAR) targets.This cross-sectional study included 180 with type 2 diabetes. TIR TAR were assessed by a continuous glucose monitoring system, target achievement defined as more than 70% less 25%. Beta-cell was insulin secretion-sensitivity index-2 (ISSI2).Following treatment, logistic regression analysis showed that lower ISSI2 associated decreased number...