- Cardiomyopathy and Myosin Studies
- Cardiovascular Effects of Exercise
- Cardiovascular Function and Risk Factors
- Cardiac electrophysiology and arrhythmias
- Trypanosoma species research and implications
- Cardiac Arrhythmias and Treatments
- Lysosomal Storage Disorders Research
- COVID-19 Clinical Research Studies
- Viral Infections and Immunology Research
- Exercise and Physiological Responses
- SARS-CoV-2 and COVID-19 Research
- Congenital Heart Disease Studies
- Cerebral Venous Sinus Thrombosis
- Connective tissue disorders research
- Neuroscience of respiration and sleep
- Genetic Neurodegenerative Diseases
- Muscle metabolism and nutrition
- Biomedical and Chemical Research
- Liver physiology and pathology
- MicroRNA in disease regulation
- Radiation Dose and Imaging
- DNA and Nucleic Acid Chemistry
- Pharmacological Receptor Mechanisms and Effects
- Biopolymer Synthesis and Applications
- Vitamin C and Antioxidants Research
University of Campania "Luigi Vanvitelli"
2020-2024
Ospedale Monaldi
2022
University of Rome Tor Vergata
2021
Biogem
2019
Princeton University
1968
A fascinating variety of proteins must interact with DNA within the cell in order to make possible such basic genetic processes as replication and repair, recombination, selective gene expression, mRNA transcription. Before function can be precisely defined at molecular level, many DNA-associated will have individually isolated characterized. We developed a general method which should facilitate analyses. This method, we call 'DNA-cellulose chromatography', relies upon fact that on inside...
Endoderm-derived organs as liver and pancreas are potential targets for regenerative therapies, thus, there is great interest in understanding the pathways that regulate induction specification of this germ layer. Currently, knowledge molecular mechanisms guide vivo endoderm restricted by lack early specific markers. Nephrocan (Nepn) a gene whose expression characterizes stages murine (E7.5–11.5) encodes secreted N-glycosylated protein. In present study, we report identification new...
Coarctation of the aorta is a leading cause morbidity and mortality among adults with congenital heart disease (ACHD). Lifelong surveillance mandatory to screen for possible long-term cardiovascular events. Left ventricular systolic dysfunction has been reported in association recoarctation, dilated cardiomyopathy (DCMP) very rare. Herein, we report case 19-year-old boy coarctation who complained mild exertional dyspnea. Cardiac magnetic resonance revealed moderately dilated, hypokinetic...
MicroRNAs (miRNAs) are single-stranded small non-coding RNA (18–25 nucleotides) that until a few years ago were considered junk RNA. In the last twenty years, they have acquired more importance thanks to understanding of their influence on gene expression and role as negative regulators at post-transcriptional level, influencing stability messenger (mRNA). Approximately 5% genome encodes miRNAs which responsible for regulating numerous signaling pathways, cellular processes cell-to-cell...
Fabry disease (FD) is a multiorgan disease, which can potentially affect any organ or tissue, with the heart, kidneys, and central nervous system representing major targets. FD be suspected based on presence of specific red flags, subsequent evaluation α-Gal A activity GLA sequencing, are required to confirm diagnosis, evaluate amenable mutation, perform cascade program screening in family members. An early diagnosis start an etiological treatment prevent irreversible damage. Here, we...
Since late 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its associated disease 2019 (COVID-19) have become a worldwide threat to public health [...]
The deletion of the arginine 14 codon (R14del) in phospholamban (PLN) gene is a rare cause arrhythmogenic cardiomyopathy (ACM) and associated with prevalent ventricular arrhythmias, heart failure, sudden cardiac death. pathophysiological mechanism which culminates ACM phenotype multifactorial mainly based on alteration endoplasmic reticulum proteostasis, mitochondrial dysfunction compromised Ca2+ cytosolic homeostasis. symptoms this condition are usually non-specific consist...
Abstract Aims This study sought to describe the characteristics and natural course of left ventricular hypertrophy (LVH) in a well-characterized consecutive cohort infants diabetic mothers (IDMs). Methods results Sixty IDMs with LVH have been retrospectively identified enrolled study. All were evaluated at baseline every 6 months until LV wall thickness regression, defined as decrease measurement into normal reference range for cardiac parameters (z-score > −2 <2). A...