A5101488220- Liver Disease Diagnosis and Treatment
- Heme Oxygenase-1 and Carbon Monoxide
- Paraquat toxicity studies and treatments
- Peroxisome Proliferator-Activated Receptors
- Diet, Metabolism, and Disease
- Cancer, Lipids, and Metabolism
- Liver physiology and pathology
- Plant responses to water stress
- Eicosanoids and Hypertension Pharmacology
- Hepatitis C virus research
- Fatty Acid Research and Health
- Liver Disease and Transplantation
- Pituitary Gland Disorders and Treatments
- Reproductive System and Pregnancy
- Traditional Chinese Medicine Analysis
- Drug-Induced Hepatotoxicity and Protection
- Natural product bioactivities and synthesis
- Extracellular vesicles in disease
- Computational Drug Discovery Methods
- Alcohol Consumption and Health Effects
- Folate and B Vitamins Research
- Acute Kidney Injury Research
- NF-κB Signaling Pathways
- Neuroendocrine Tumor Research Advances
- Endometriosis Research and Treatment
Hebei Medical University
2019-2024
Ministry of Agriculture and Rural Affairs
2023
China Agricultural University
2023
Shinshu University
2016-2021
Mayo Clinic
2020
WinnMed
2020
Mayo Clinic in Arizona
2020
China Medical University
2009-2020
Shanghai Xuhui Central Hospital
2020
During liver fibrosis, sinusoidal endothelial cells (LSECs) release angiocrine signals to recruit inflammatory into the liver. p300, a master regulator of gene transcription, is associated with pathological response. Therefore, we examined how p300 regulates signaling and inflammation related portal hypertension fibrogenesis.CCl4 or partial inferior vena cava ligation (pIVCL) was used induce injury. Mice LSEC-specific deletion (p300LSECΔ/Δ ) C-C motif chemokine ligand 2 (Ccl2) deficiency,...
Paraquat (PQ) is a widely used herbicide with extremely high poisoning mortality mostly from acute lung injury (ALI) or progressive pulmonary fibrosis. Toxicity mechanisms remain unclear, but redox cycling process that generates reactive oxygen species (ROS) involved, as are inflammation and cell apoptosis. We established an ALI mouse model by intraperitoneal injection of PQ (28 mg/kg) then investigated the effects potent liver X receptor (LXR) agonist, TO901317 (5 20 mg/kg), injected...
Transforming growth factor (TGF-β)-induced activation of quiescent hepatic stellate cells (HSCs) and their transformation to myofibroblasts is a key event in liver fibrosis portal hypertension. GIPC (also referred as synectin) downstream signal molecule TGF-β other receptors. In this study, we sought identify novel genes targeted by elucidate if how they may contribute fibrosis.
Decidualization is a progesterone-dependent cellular differentiation process that essential for establishing pregnancy. Robust activation of glycolysis and lactate synthesis during decidualization remarkable, but their developmental functions remain largely unknown. Herein, we identify endometrial production plays critical role in local histone lactylation, newly identified modification, important ensuring normal decidualization. Enhanced the hallmark metabolic change tightly coupled with...
Dietary restriction (DR) is a preventive strategy for obesity, metabolic syndrome, cardiovascular disease, and diabetes. Although an interconnection between fatty liver, hepatocellular carcinoma has been documented, the mechanism impact of DR on steatosis-derived hepatocarcinogenesis are not fully understood. This study aimed to evaluate whether can prevent hepatic tumorigenesis.Male hepatitis C virus core gene transgenic (HCVcpTg) mice that develop spontaneous age-dependent insulin...
Abstract Excess consumption of trans-fatty acid (TFA), an unsaturated fatty containing trans double bonds, is a major risk factor for cardiovascular disease and metabolic syndrome. However, little known about the link between TFA hepatocellular carcinoma (HCC) despite it being frequent form cancer in humans. In this study, impact excessive dietary on hepatic tumorigenesis was assessed using hepatitis C virus (HCV) core gene transgenic mice that spontaneously developed HCC. Male were treated...
Vasoactive intestinal peptide-producing tumors (VIPoma) usually originate in the pancreas and are characterized by diarrhea, hypokalemia, achlorhydria (WDHA syndrome). In adults, nonpancreatic VIPoma is very rare. Herein, we report an unusual case of VIP-producing pheochromocytoma marked persistent shock, flushing, watery diarrhea high sensitivity to octreotide. A 53-year-old woman was hospitalized for sudden-onset hypertension with convulsions, which then rapidly evolved diarrhea. Abdominal...
Hepatitis C virus (HCV) is a major cause of chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma (HCC) worldwide. Among the structural proteins HCV, HCV core protein has ability to regulate gene transcription, lipid metabolism, cell proliferation, apoptosis, autophagy, all which are closely related development HCC. Transgenic mice carrying exhibited age-dependent insulin resistance, hepatic steatosis, HCC that resembled clinical characteristics hepatitis patients. Several dietary...
Objective To observe the therapeutic effects of somatostatin administered in different speeds on severe acute pancreatitis during hemoperfusion. Methods A total 112 patients with routine treatment emergency intensive care unit were divided into control group and experimental according to speed injection hemoperfusion. Patients (n=56) received accelerated somatostatin, while got a steady injection. The time required for relieving clinical symptoms, consumed resuming normal results...
Objective To investigate the protective effects and possible mechanisms of GW3965, a liver X receptors (LXRs) agonist, in mice with PQ-induced acute lung injury. Methods A total 40 male c57BL/6J were randomly(random number) divided into four groups. In control group, intra-peritoneally injected 0.1 mL normal saline solution twice at an interval 10 min. paraquat poisoning dose 28 mg/kg min later. low GW3965 treatment after PQ administration. high 50 The sacrificed 72 h administration...