A5101451801- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Cancer therapeutics and mechanisms
- Pancreatic and Hepatic Oncology Research
- Phagocytosis and Immune Regulation
- Extracellular vesicles in disease
- HER2/EGFR in Cancer Research
- Neuroendocrine Tumor Research Advances
- Cancer Immunotherapy and Biomarkers
- Reproductive Biology and Fertility
- Ethics in Clinical Research
- Health Systems, Economic Evaluations, Quality of Life
- MicroRNA in disease regulation
- Media Studies and Communication
- Immune Cell Function and Interaction
- PI3K/AKT/mTOR signaling in cancer
- Social Media and Politics
- Acute Lymphoblastic Leukemia research
- Biomedical Ethics and Regulation
- Medication Adherence and Compliance
- Circular RNAs in diseases
- Cancer-related gene regulation
- Cancer Mechanisms and Therapy
- Blood Pressure and Hypertension Studies
- ATP Synthase and ATPases Research
Asan Medical Center
2014-2023
University of Ulsan
2014-2023
Ulsan College
2013-2023
Seoul Medical Center
2022
Gangnam Severance Hospital
2018
Yonsei University
2010-2018
Health Insurance Review and Assessment Service
2017
Hanyang University
2013-2016
Faculty of Media
2006-2013
Kangwon National University
2010
Abstract Programmed cell death protein-1/programmed ligand-1 (PD-1/PD-L1) pathway blockade is a promising new cancer therapy. Although PD-1/PD-L1 treatment has yielded clinical benefits in several types of cancer, further studies are required to clarify predictive biomarkers for drug efficacy and understand the fundamental mechanism interaction between host tumor cells. Here, we show that exosomes derived from lung cells express PD-L1 play role immune escape by reducing T-cell activity...
In non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) mutations, acquired resistance to EGFR-tyrosine kinase inhibitors (EGFR-TKI) can occur through a generation of bypass signals such as MET or AXL activation. this study, we investigated the antitumor activity NPS-1034, newly developed drug that targets both and AXL, in NSCLC cells gefitinib erlotinib (HCC827/GR HCC827/ER, respectively). Characterization H820 evaluation NPS-1034 efficacy these were also...
Epithelial‐mesenchymal transition (EMT) is associated with reduced sensitivity to many chemotherapeutic drugs, including EGFR tyrosine kinase inhibitors. Here, we investigated if this also contributes resistance crizotinib, an ALK inhibitor of lung cancer that exhibits the EML4‐ALK translocation. We established a crizotinib‐resistant subline (H2228/CR), which was derived from parental H2228 cell line by long‐term exposure increasing concentrations crizotinib. Characteristics EMT, morphology,...
Abstract Background Small cell lung cancer (SCLC) has an exceptionally poor prognosis; as most of the cases are initially diagnosed extensive disease with hematogenous metastasis. Therefore, early diagnosis SCLC is very important and may improve its prognosis. Methods To investigate feasibility SCLC, we examined exosomal microRNAs (miRNAs) present in serum obtained from patients SCLC. First, exosomes were isolated healthy individuals characterized using particle size protein markers....
Mutant-selective, 3rd-generation EGFR-TKIs were recently developed to control lung cancer cells harboring T790M-mediated resistance. However, the development of resistance these novel drugs seems inevitable. Thus, we investigated mechanism acquired mutant-selective EGFR-TKI WZ4002. We established five WZ4002-resistant cells, derived from both EGFR and T790M mutations by long-term exposure increasing doses Compared with parental all resistant showed 10-100-folds higher WZ4002, as well...
Abstract Oncogenic EGFR is essential for the development and growth of non–small cell lung cancer (NSCLC), but precise roles in metabolism remain unclear. Here, we show that mutation-mediated enhancement glycolysis critical stability. knockdown significantly decreased levels glycolytic pathway intermediates via transcriptional regulation genes. mutation-enhanced was required fueling tricarboxylic acid cycle, a component Nonsustained ATP production enhanced reactive oxygen species...
Tumor-derived exosomes (TEXs) contain enriched miRNAs, and exosomal miRNAs can affect tumor growth, including cell proliferation, metastasis, drug resistance through cell-to-cell communication. We investigated the role of miR-1260b derived from non-small lung cancer (NSCLC) in progression. Exosomal induced angiogenesis by targeting homeodomain-interacting protein kinase-2 (HIPK2) human umbilical vein endothelial cells (HUVECs). Furthermore, or suppression HIPK2 led to enhanced cellular...
Male germ cell apoptosis has been extensively explored in rodents. In contrast, very little is known about the susceptibility of developing cells to response busulfan treatment. Spontaneous rarely observed adult mouse testis, but under experimental conditions described here, busulfan‐treated mice exhibited a marked increase and decrease testis weight. TdT‐mediated dUTP‐X nicked end labeling analysis indicates that at one week following treatment, was confined mainly spermatogonia, with...
To assess the utility of F-18 fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) in evaluating pancreatic intraductal papillary mucinous neoplasm (IPMN).We included 31 patients with IPMN who underwent FDG PET/CT and multidetector CT (MDCT). Each lesion was classified as benign or malignant. On PET, maximal standardized uptake value measured each lesion.PET/CT superior to MDCT diagnosing malignant IPMN. All 22 concordant results gave accurate diagnoses. Of 9...
The emergence of resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in non-small cell lung cancer (NSCLC) with activating EGFR mutations is a major hindrance treatment. We investigated the effects p53 primary sensitivity and acquired EGFR-TKIs NSCLC cells. Changes were determined using overexpression or knockdown cells mutations. EMT-related molecules, morphologic changes, AXL induction elucidate mechanisms according status. status affected as well type....
Abstract Although epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKI) produce an initially dramatic response in lung cancer patients harboring a mutation the EGFR gene, development of acquired resistance is almost inevitable. A secondary threonine 790 (T790M) associated with approximately half cases resistance. This study investigated whether addition silibinin to therapy gefitinib or erlotinib could overcome T790M-mediated drug considering that has various antitumor...
Protein kinase CK2 has diverse functions promoting and maintaining cancer phenotypes. We investigated the effect of inhibition in lung cells with T790M-mediated resistance to EGFR-TK inhibitor. Resistant sublines PC-9 gefitinib (PC-9/GR) erlotinib (PC-9/ER) were established by previous study, T790M secondary mutation was found both resistant sublines. A decrease EGFR siRNA treatment effectively controlled growth cells, thus suggesting that they still have EGFR-dependency. CX-4945, a potent...
Considering general public as potential patients, identifying factors that hinder participation poses great importance, especially in a research environment where demands for clinical trial participants outpace the supply. Hence, aim of this study was to evaluate knowledge and perception about public. A total 400 Seoul residents with no previous experience were selected, representative population terms age sex. To minimize selection bias, every fifth passer-by invited interview, if cluster,...
The activation of bypass signals, such as MET and AXL, has been identified a possible mechanism EGFR-TKI resistance. Because various oncoproteins depend on HSP90 for maturation stability, we investigated the effects AUY922, newly developed non-geldanamycin class inhibitor, in lung cancer cells with MET- AXL-mediated We established resistant cell lines HCC827 harboring an exon 19-deletion mutation EGFR gene via long-term exposure to increasing concentrations gefitinib erlotinib (HCC827/GR...
Effects of Initial Therapeutic ClassesWe aimed to assess one-year persistence with antihypertensive therapy (AHT) among newly treated uncomplicated hypertensive patients in Korea and evaluate the effect initial therapeutic classes on persistence.We retrospectively analyzed a random sample 20% (n = 45,787) 2012 from National Health Insurance claims database.This group was classified into six cohorts based AHT class.We then measured treatment persistence, allowing prescription gap 60...
Purpose This nationwide retrospective study was conducted to evaluate the efficacy and safety of combined gemcitabine docetaxel (GD) as an off-label therapy for advanced soft tissue sarcoma, which has limited treatment options owing its rare occurrence. Materials Methods A total 228 patients received GD sarcoma from 2009 2014 in Korea. We retrospectively reviewed clinical medical records claims data these patients. Results 218 20 centers were included final analysis (median age, 50.0 years)....
Because anaplastic lymphoma kinase (ALK) is dependent on Hsp90 for protein stability, inhibitors are effective in controlling growth of lung cancer cells with ALK rearrangement. We investigated the mechanism acquired resistance to 17-(Dimethylaminoethylamino)-17-demethoxygeldanamycin (17-DMAG), a geldanamycin analogue inhibitor, H3122 and H2228 non-small cell lines Resistant (H3122/DR-1, H3122/DR-2 H2228/DR) were established by repeated exposure increasing concentrations 17-DMAG. Mechanisms...
Epithelial to mesenchymal transition (EMT) is associated with resistance during EGFR tyrosine kinase inhibitor (EGFR-TKI) therapy. Here, we investigated whether EMT acquired 3rd generation EGFR-TKIs, and explored the effects of cyclin-dependent 7 (CDK7) inhibitors on EMT-mediated EGFR-TKIs in non-small cell lung cancer (NSCLC). We established EGFR-TKI resistant lines (H1975/WR H1975/OR) via repeated exposure WZ4002 osimertinib. The two showed phenotypic changes a spindle-cell shape, had...
Abstract The genetic association of the methylenetetrahydrofolate reductase gene ( MTHFR ) 677C>T polymorphism with methotrexate (MTX)‐associated toxicity has been evaluated and conflicting results have reported. substantial heterogeneity studied population was suggested to be a possible explanation because ethnicity, MTX dose, coadministered chemotherapeutic agents, folinate rescue dosage regimen could alter profile. patient homogenized by limiting cancer type primary central nervous...
Small cell lung cancer (SCLC) transformation during epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) treatment in has been suggested as one of possible resistance mechanisms.We evaluated whether SCLC or neuroendocrine (NE) differentiation can be found the line model. In addition, we also investigated its effect on responses to conventional chemotherapeutic drugs treatment.Resistant lines various kinds EGFR-TKIs such gefitinib, erlotinib, CL-387,785 and ZD6474 with A549,...