A5025662550- Heme Oxygenase-1 and Carbon Monoxide
- Anesthesia and Neurotoxicity Research
- Acute Kidney Injury Research
- Inflammasome and immune disorders
- Anesthesia and Pain Management
- Cardiac Ischemia and Reperfusion
- Intensive Care Unit Cognitive Disorders
- Thermal Regulation in Medicine
- Eicosanoids and Hypertension Pharmacology
- Anesthesia and Sedative Agents
- Genomics, phytochemicals, and oxidative stress
- RNA Interference and Gene Delivery
- Nausea and vomiting management
- Cancer, Stress, Anesthesia, and Immune Response
- Nanoparticle-Based Drug Delivery
- Advanced battery technologies research
- Acupuncture Treatment Research Studies
- Heavy Metal Exposure and Toxicity
- Pancreatic function and diabetes
- Sympathectomy and Hyperhidrosis Treatments
- EEG and Brain-Computer Interfaces
- Immune cells in cancer
- Salmonella and Campylobacter epidemiology
- Vagus Nerve Stimulation Research
- Cardiac, Anesthesia and Surgical Outcomes
Cangzhou Central Hospital
2017-2023
Hebei Medical University
2013-2023
Second Hospital of Hebei Medical University
2023
Zhengzhou University
2020-2022
Third Hospital of Hebei Medical University
2013-2022
Hubei University of Medicine
2022
Tianjin Medical University
2019-2021
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2019
Wenzhou Medical University
2019
The activation of pyroptosis is an important feature renal ischemia/reperfusion (rI/R)-induced acute lung injury (ALI).Propofol, a general anesthetic, known to inhibit inflammation in I/R-induced ALI.We investigated whether propofol could suppress during rI/R-induced ALI by upregulating sirtuin 1 (SIRT1).We generated vivo model applying microvascular clamps the pedicles rats for 45 min.Pathological studies revealed that rI/R provoked substantial and inflammatory cell infiltration.The...
Propofol (Pro) confers protection against renal ischemia/reperfusion (rI/R) injury through incompletely characterized mechanisms. Since Pro has shown net anti-inflammatory properties as part of its beneficial effects, we examined the potential role in modulation macrophage polarization status during both rI/R vivo and exposure cultured peritoneal macrophages (PMs) to hypoxia/reoxygenation (H/R). Rats were subjected 45-min r/IR surgery or a sham procedure administered PBS (vehicle) ischemia...
Purpose: To evaluate the effect of esketamine combined with ultrasound-guided pectoral nerve block type II (Pecs block) on quality early postoperative recovery in patients undergoing a modified radical mastectomy (MRM) for breast cancer. Patients and Methods: A total 136 female an elective MRM unilateral cancer (UBC) first time were randomly divided into control group (group C, n=68) experimental (PE group, n=68). In sufentanil was used anesthesia induction patient-controlled intravenous...
The prognosis of patients with leptomeningeal metastasis (LM) remains poor. Circulating tumour DNA (ctDNA) has been proven to be abundantly present in cerebrospinal fluid (CSF); hence, its clinical implication as a biomarker needs further verified.We conducted retrospective study 35 lung adenocarcinoma (LUAD) LM, and matched CSF plasma samples were collected from all patients. All paired underwent next-generation sequencing (NGS) 139 cancer-associated genes. characteristics genetic profiling...
Lung diseases are common health problems in many countries. The dysfunction of bronchial epithelial cells is important for the development lung diseases. Recent progress reveals that inflammasome fundamental mechanism activation. Here, we report protective effect doxofylline, a theophylline derivative agent, on lipopolysaccharides (LPS)-induced inflammatory response cells. presence doxofylline reduces LPS-induced production NO and PGE2. Doxofylline also inhibits mitochondrial ROS....
Neurobrucellosis (NB) presents a challenge for rapid and specific diagnosis. Next-generation sequencing (NGS) of cerebrospinal fluid (CSF) has showed power in detection causative pathogens, even some infrequent unexpected pathogens. In this study, we presented 8 cases NB diagnosed by the NGS CSF.Between August 1, 2018 September 30, 2020, was used to detect pathogens clinically suspected central nervous system (CNS) infections. Data on demographics, clinical features, laboratory tests,...
The nuclear factor (NF)-κB and NOD-like receptor protein 3 (NLRP3) pathways promote inflammatory signaling that injures the kidneys, whereas erythroid 2-related 2 (Nrf2) pathway promotes anti-inflammatory inhibits oxidative damage. Penehyclidine hydrochloride (PHC) NF-κB activates Nrf2 signaling. We investigated whether PHC induces communication between NF-κB/NLRP3 pathways, thereby protecting against renal ischemia/reperfusion (rI/R)-induced lung inflammation. Rat alveolar macrophages...
A new technique for analgesia called pectoral nerve block is widely used in surgeries of breast cancer. Pectoral type II (Pecs II) has less influence on immunity when compared with general anesthesia method. The purpose this research to demonstrate whether Pecs the recurrence cancer after surgical operation.526 patients were recruited and randomized into group group. Recurrence-free survival (RFS), distant recurrence-free (DRFS), overall (OS) evaluated two groups.Based statistical data, only...
Introduction. The prompt and specific diagnosis of Listeria monocytogenes meningoencephalitis (LMM) is challenging. Next-generation sequencing (NGS) cerebrospinal fluid (CSF) an emerging technique for diagnosing infrequent causative pathogens.Hypothesis/Gap statement. We hypothesized that NGS CSF effective approach LMM.Aim. To evaluate the effectiveness NGS, we present five cases LMM diagnosed using CSF.Methodology. Between August 2017 30 September 2020, used to detect pathogens in patients...
Introduction: Sepsis-mediated acute lung injury (ALI) is a critical clinical condition. Artesunate (AS) sesquiterpene lactone endoperoxide that was discovered in Artemisia annua, which traditional Chinese herb. AS has broad set of biological and pharmacological actions; however, its protective effect on lipopolysaccharide (LPS)-induced ALI remains unclear. Methods: LPS-mediated induced rats through bronchial LPS inhalation. Then NR8383 cells were treated with to establish an vitro model....
Objectives Heavy metal exposure has been associated with lung function decline, but there is still a lack of evidence on preschoolers. In this study, we evaluated cross-sectional associations between urinary levels and slow vital capacity (SVC) in preschoolers.Methods A total 1284 children were selected from seven-kindergartens. Urinary concentrations 23 metals measured by inductively coupled plasma mass spectrometry. Utilized least absolute shrinkage selection operator penalized regression...
The present study investigated the effect of enalapril on myocardial infarction (MI) and its mechanism action in mice. Treatment with significantly attenuated cellular apoptosis death. In vivo, treatment alleviated MI injury, decreased size infarct area. This was paralleled by increased Bcl‑2 expression, Bax a caspase‑3 level, expression endoplasmic reticulum stress‑associated proteins, including activating transcription factor 6 78 kDa glucose‑regulated protein, fewer TUNEL‑positive cells...
Introduction: Penehyclidine hydrochloride (PHC) is an anticholinergic with anti-inflammatory and anti-oxidation activities. PHC displayed protectivity against renal ischemia reperfusion (RIR) injury. Nevertheless, the precise of on RIR-induced lung injury remains unknown. Methods: We examined effects investigated underlying mechanism. induced RIR in mice administrated to mice. Kidney function was monitored by measuring blood urea nitrogen (BUN) creatinine level serum. evaluated injury,...
ABSTRACTABSTRACTObjective To investigate whether central sensitization (CS) in elderly patients was a predictive risk factor for postoperative neurocognitive dysfunction (PNCD).Methods One hundred and thirty-three aged undergoing total knee arthroplasty (TKA) who received femoral nerve block general anesthesia were recruited this research prospectively assigned into two groups according to the Central Sensitization Inventory (CSI) score: group C (n = 106, CSI score less than 40) CS 27,...
<b><i>Objective:</i></b> We evaluated the efficacy of electroacupuncture combined with tropisetron in treating carboprost tromethamine-induced nausea and vomiting during cesarean section under lumbar anesthesia. <b><i>Methods:</i></b> A total 264 patients aged 22–40 years were enrolled, who received tromethamine suffered The divided randomly into control group, + group. <b><i>Results:</i></b> Compared to scores decreased...