A5032763759- Pharmacogenetics and Drug Metabolism
- Lipoproteins and Cardiovascular Health
- Antiplatelet Therapy and Cardiovascular Diseases
- Hormonal Regulation and Hypertension
- Innovations in Medical Education
- Pharmaceutical Practices and Patient Outcomes
- Cardiovascular Disease and Adiposity
- Occupational Health and Performance
- Eicosanoids and Hypertension Pharmacology
- Inflammatory mediators and NSAID effects
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Heart Failure Treatment and Management
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diabetes Treatment and Management
- Health Sciences Research and Education
- Cancer, Lipids, and Metabolism
- Pharmaceutical studies and practices
- Cardiovascular Health and Disease Prevention
- Cardiovascular Health and Risk Factors
- Cardiovascular Effects of Exercise
- Problem and Project Based Learning
- Genetic Associations and Epidemiology
- Patient Safety and Medication Errors
- Vitamin K Research Studies
Mercer University Health Sciences Center
2012-2024
American College of Clinical Pharmacy
2021
Mercer University
2010-2015
Merck (United Kingdom)
2015
Saint Joseph's Hospital
2011
IST Research
2010
University of Illinois Chicago
2006-2010
Saint Joseph’s Translational Research Institute
2008-2010
The objective of this study was to determine whether, in African-American patients, additional vitamin K oxidoreductase complex subunit 1 (VKORC1), cytochrome P450 2C9 (CYP2C9), CYP4F2, or apolipoprotein E (APOE) polymorphisms contribute variability the warfarin maintenance dose beyond what is attributable CYP2C9*2 and *3 alleles VKORC1 −1639G>A genotype. In a cohort 226 weekly requirements were lower those with CYP2C9*8 allele (34 (30–47) mg; P = 0.023) CYP2C9 *2, *3, *5, *6, *11 (33(28–40...
Introduction: African–Americans are under-represented in studies assessing contributors to warfarin response. Our primary objective was determine whether the genes for cytochrome P450 (CYP) 2C9, nicotinamide adenine dinucleotide phosphate, reduced, quinone oxidoreductase (NQO1) and vitamin K epoxide reductase complex subunit 1 (VKORC1) associated with dose requirements African–Americans. Patients methods: The following factors were assessed: demographics; clinical data; CYP2C9 Arg144Cys...
Objective: To determine the association of cardiovascular risk markers with noninvasive imaging atherosclerosis in firefighters. Methods: Cross-sectional investigation subclinical metabolic, work related, and life-style variables 296 professional Results: Calcified coronary (CAC), carotid arterial intimal thickness (CIMT), electrocardiogram provided independent CVD assessments. Homeostatic Model Assessment (HOMA) concentrations were related to heart-rate-corrected QT (QTc) (slope ± SE: 2.16...
Objective. To evaluate levels of entrustability and practice readiness in advanced pharmacy experience (APPE) students using a pilot instrument designed to assess their competency performing the entrustable professional activities (EPAs) expected new graduates. Methods. A was developed directly from EPAs measure on scale one five. Five APPE preceptors several different areas participated. Fourth-year used self-evaluate knowledge skills at beginning, midpoint, end APPE. The evaluated same...
To compare cytochrome P450 activity in people with and without cancer examine the relationship between CYP2C9 serum cytokine levels.10 subjects who were currently receiving treatment 10 additional matched to based on gender race enrolled into study. Serial blood samples drawn measure tolbutamide plasma before after oral 500 mg. Total urine excreted was collected from 0 12 h following dose. Tolbutamide its metabolites measured by HPLC. genotype determined PCR pyrosequencing values ELISA.The...
Patients with HIV are at an increased risk for cardiovascular disease, both as a result of treatment protease inhibitors and from the disease itself. The medication regimens patients comorbidities complex require careful assessment potentially serious drug-drug interactions. We report case clopidogrel non-responsiveness in patient HIV, latent tuberculosis history myocardial infarction. To our knowledge, this is first significant drug interactions between clopidogrel, isoniazid ritonavir....
Evidence of racial differences in aldosterone concentrations and K+ disposition suggests that response to antagonism might vary by race. The authors sought determine whether spironolactone differs between African Americans Caucasians with heart failure. Heart failure patients African‐American (n=34) or Caucasian (n=17) race were started on 12.5 mg/d, up‐titration as tolerated. Laboratory values drug therapy similar groups at baseline. Spironolactone was titrated a median dose 25 mg/d both...
Aim: To assess the association between CETP Taq1B and I405V polymorphisms with levels of lipoprotein subclasses in African-American (AA) men without Type 2 diabetes (T2DM). Patients & methods: AA men, over 30 years age, (n = 54) or T2DM 50), not receiving lipid-lowering agents, underwent advanced lipid analysis genotyping. Results conclusion: In total patient population B2-allele carriers had significantly higher large HDL (HDL-2b [p 0.017] HDL-L 0.019]), lower small-HDL (HDL-3a 0.004]...
Cardiac fibrosis plays an important role in the pathophysiology of heart failure. The authors sought to determine whether biomarkers cardiac for milder clinical degrees failure are comparable those more advanced disease. Procollagen types I and III amino‐terminal peptides (PINP PIIINP) type collagen telopeptide (ICTP) were compared between aldosterone‐antagonistnaive patients with New York Heart Association class or II (n=22/23) IV (n=42/3) symptoms. Median (interquartile) range...