A5100435195- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Immune cells in cancer
- Lung Cancer Diagnosis and Treatment
- Peripheral Neuropathies and Disorders
- Glioma Diagnosis and Treatment
- MicroRNA in disease regulation
- Esophageal Cancer Research and Treatment
- Spinal Cord Injury Research
- Cancer Genomics and Diagnostics
- Spinal Hematomas and Complications
- Pleural and Pulmonary Diseases
- Cancer-related molecular mechanisms research
- Psoriasis: Treatment and Pathogenesis
- Intraoperative Neuromonitoring and Anesthetic Effects
- Health Systems, Economic Evaluations, Quality of Life
- RNA and protein synthesis mechanisms
- Cancer Diagnosis and Treatment
- Genetic factors in colorectal cancer
- Multiple Sclerosis Research Studies
- Spinal Fractures and Fixation Techniques
- Scoliosis diagnosis and treatment
- Multiple and Secondary Primary Cancers
- Healthcare Systems and Reforms
- Epigenetics and DNA Methylation
Wuhan University
2021-2025
Zhongnan Hospital of Wuhan University
2022-2025
Chinese People's Liberation Army
2023
Second Military Medical University
2023
Renmin Hospital of Wuhan University
2021
Henan Agricultural University
2021
Weatherford College
2021
Southern Medical University
2019
Nanfang Hospital
2019
Second Affiliated Hospital of Xi'an Jiaotong University
2015-2017
Nuf2 participates in the regulation of cell apoptosis and proliferation by regulating binding centromere spindle microtubules to achieve correct separation chromosomes. Previous reports have suggested that may play a role various human cancers. However, mechanism function development Hepatocellular carcinoma (HCC) remains uncertain. This study investigated prognostic potential its relation with immune infiltration HCC. expression tumor cells was examined using TIMER Oncomine databases,...
Abstract Our research endeavors are directed towards unraveling the stem cell characteristics of lower-grade glioma patients, with ultimate goal formulating personalized treatment strategies. We computed enrichment stemness scores and performed consensus clustering to categorize phenotypes. Subsequently, we constructed a prognostic risk model using weighted gene correlation network analysis (WGCNA), random survival forest regression as well full subset analysis. To validate expression...
The RNA N6-methyladenosine (m6A) modification is a critical regulator of various biological processes, but precise and dynamic control m6A remains challenge. In this work, we present red/far-red light-inducible editing system that enables efficient reversible modulation levels with minimal off-target effects. By engineering the CRISPR dCas13 protein sgRNA two pairs heterodimerizing proteins, ΔphyA/FHY1 Bphp1/PspR2, achieved targeted recruitment effectors. This significantly enhances writing...
Abstract Objective To evaluate the financial burden of oesophageal cancer under protection new Rural Cooperative Medical Scheme ( NCMS ) and to provide evidence suggestions policymakers in a high‐incidence region China. Methods We analysed inpatient claim data for cancer, gastric colorectal from 1 January 31 December 2013. The were extracted management system Hua County, Henan Province, typical high‐risk Cancer‐specific health economic indicators calculated local . Results total cost was...
Background: Glioblastoma (GBM), which has a poor prognosis, accounts for 31% of all cancers in the brain and central nervous system. There is paucity research on prognostic indicators associated with tumor immune microenvironment GBM patients. Accurate tools risk assessment patients are urgently needed. Methods: In this study, we used weighted gene co-expression network analysis (WGCNA) differentially expressed (DEG) methods to screen out GBM-related genes among immune-related (IRGs). Then,...
Transbronchial lung biopsy guided by radial probe endobronchial ultrasonography with a guide sheath (EBUS-GS-TBLB) is becoming significant approach for diagnosing peripheral pulmonary lesions (PPLs). We aimed to explore the clinical value of resistance pass through lesion in diagnosis PPLs when performing EBUS-GS-TBLB, and determine optimum number EBUS-GS-TBLB.We performed prospective, single-center study 126 consecutive patients who underwent EBUS-GS-TBLB solid positive-bronchus-sign where...
With high mortality and poor prognosis, hepatocellular carcinoma (LIHC) has become the fourth leading cause of cancer-related deaths worldwide. Most LIHC patients missed best treatment period because untimely diagnosis. For others, even if they are temporarily cured, have to face a very low prognostic survival rate risk recurrence. Based on characteristics abnormal proliferation uncontrolled growth tumor cells. Cell Division Cycle Associated ( CDCA ) family genes, which responsible for...
Abstract Background Mismatch‐repair genes (MMRs) ensure high fidelity in genome editing. Loss of function mutation MMRs will lead to instability the and increase incidence cancers. Human mutL homolog 1 (MLH1) is a member MMRs, its found Lynch syndrome (LS). In addition colorectal cancer, LS patients often have other primary Here, case LS‐associated lung gastric double cancer was reported. Methods Diagnosis mainly based on clinical findings, imaging examination, histopathological data. The...
With the increasing aging, elderly need to be treated by "sunshine". Through field investigation, it is found that interior corridor layout and end of are windowless, resulting in poor ventilation lighting. After software simulation analysis optimization design, experiment results show illumination evenness public activity space have been improved, so overall lighting effect inner without direct has significantly natural light distribution more uniform, providing a comfortable living...
Prognosis prediction is crucial for determining optimal treatment plans lung cancer patients. Traditionally, such predictions relied on models developed from retrospective patient data. Recently, large language (LLMs) have gained attention their ability to process and generate text based extensive learned knowledge. In this study, we evaluate the potential of GPT-4o mini GPT-3.5 in predicting prognosis We collected two datasets, i.e., survival post-operative complication designed multiple...
Abstract Background Cancer stem cells (CSCs), which are capable of infinite proliferation and self-renewal, play a crucial role in the occurrence development colorectal cancer (CRC). The study expression characteristics CRC cell-related genes their interaction with immune microenvironment may contribute to treatment. Results In order explore hub that regulate stemness CRC, we obtained gene values Genome Atlas (TCGA), indices (mRNAsi), corresponding survival data from UCSC Xena Browser....