A5068450052- Nutritional Studies and Diet
- Vitamin D Research Studies
- Health Systems, Economic Evaluations, Quality of Life
- Antioxidant Activity and Oxidative Stress
- Statistical Methods in Clinical Trials
- Health disparities and outcomes
- Cancer Risks and Factors
- Food Security and Health in Diverse Populations
- Advanced Causal Inference Techniques
- Nutrition, Genetics, and Disease
- Telomeres, Telomerase, and Senescence
- Global Cancer Incidence and Screening
- Dietary Effects on Health
- Colorectal Cancer Screening and Detection
- Retinoids in leukemia and cellular processes
- Vitamin C and Antioxidants Research
- Cardiac pacing and defibrillation studies
- Growth Hormone and Insulin-like Growth Factors
- Cancer, Stress, Anesthesia, and Immune Response
- Consumer Attitudes and Food Labeling
- Poisoning and overdose treatments
- Economic and Financial Impacts of Cancer
- Cardiovascular Health and Risk Factors
- Metabolism, Diabetes, and Cancer
- Pharmacovigilance and Adverse Drug Reactions
United States Food and Drug Administration
2013-2025
Center for Devices and Radiological Health
2022-2025
Icahn School of Medicine at Mount Sinai
2025
Center for Drug Evaluation and Research
2014-2023
Software (Spain)
2019
Center for Surveillance, Epidemiology, and Laboratory Services
2017
National Cancer Institute
2010-2014
Division of Cancer Epidemiology and Genetics
2010-2014
National Institutes of Health
2010-2014
AARP
2012
Abstract BACKGROUND: No previous prospective US study has examined whether the incidence of colorectal cancer (CRC) is disproportionately high in low socioeconomic status (SES) populations both men and women. This relationship between individual area‐level SES CRC incidence, overall by tumor location. METHODS: Data were obtained from ongoing National Institutes Health‐AARP Diet Health Study persons (50‐71 years old) who resided 6 states 2 metropolitan areas at baseline 1995‐1996. Incident...
BackgroundHealth behaviors are known risk factors for colorectal cancer and more common in low socioeconomic status (SES) populations. We evaluated the extent to which behavioral body mass index (BMI) explain SES disparities incidence, overall by tumor location.
Retinol is one of the most biologically active forms vitamin A and hypothesized to influence a wide range human diseases including asthma, cardiovascular disease, infectious cancer. We conducted genome-wide association study 5006 Caucasian individuals drawn from two cohorts men: Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study Prostate, Lung, Colorectal, Ovarian (PLCO) Screening Trial. identified independent single-nucleotide polymorphisms associated with circulating retinol...
Meat intake has been positively associated with incidence and mortality of chronic diseases, including diabetes, heart disease, several different cancers, in observational studies by using self-report methods dietary assessment; however, these assessment are subject to measurement error. One method circumvent such errors is the use biomarkers intake, but currently there no accepted for meat intake.We investigated four analytes (creatinine, taurine, 1-methylhistidine, 3-methylhistidine)...
Recent studies have produced inconsistent findings regarding the outcomes of percutaneous microaxial left ventricular assist device (LVAD) during acute myocardial infarction with cardiogenic shock (AMICS).
Background: Breast implant surfaces are categorized as smooth or textured. Compared with implants, textured surface implants have a higher risk of breast implant–associated anaplastic large cell lymphoma (BIA-ALCL) but may lower capsular contracture (CC). This study aimed to quantify whether survey respondents would be willing accept BIA-ALCL in exchange for the potential reported benefits implants. Methods: We fielded threshold technique 405 from 4 cohorts: (1) patients cancer who were...
Purpose Residing in deprived areas may increase risk of mortality beyond that explained by a person's own SES-related factors and lifestyle. The aim this study was to examine the relation between neighborhood socioeconomic deprivation all-cause, cancer- cardiovascular disease (CVD)-specific for men women after accounting education other important person-level factors. Methods In longitudinal NIH-AARP Study, we analyzed data from healthy participants, ages 50–71 years at baseline (1995–1996)....
Adverse socioeconomic conditions, at both the individual and neighborhood level, increase risk of colorectal cancer (CRC) death, but little is known regarding whether CRC survival varies geographically extent to which area-level deprivation affects this geographic variation. Using data from National Institutes Health (NIH)-AARP Diet Study, authors examined variation role in survival. cases (n = 7,024), identified during 1995-2003, were followed for their CRC-specific vital status through...
Postapproval drug safety studies often use propensity scores (PSs) to adjust for a large number of baseline confounders. These may involve examining whether treatment varies across subgroups. There are many ways PS could be used confounding in subgroup analyses. methods have trade-offs that not well understood. We conducted plasmode simulation compare relative performance 5 involving matching analysis, including frequently applied literature whose has been previously directly compared....
Circulating 25-hydroxyvitamin D (25(OH)D), a marker for vitamin status, is associated with bone health and possibly cancers other diseases; yet, the determinants of 25(OH)D particularly ultraviolet radiation (UVR) exposure, are poorly understood. Determinants were analyzed in subcohort 1,500 participants US Radiologic Technologists (USRT) Study that included whites (n = 842), blacks 646), people races/ethnicities 12). Participants recruited monthly (2008–2009) across age, sex, race, ambient...
Although numerous studies have explored the relation of IGF-I with cancer incidence, few investigated association between and mortality.This study examined serum levels mortality in older community-dwelling men.We conducted a prospective, population-based 633 men aged 50 yr (mean = 73) who attended 1988-1991 research clinic visit when blood was obtained for measurement IGF-I. Participants were followed vital status through July 2006.All-cancer assessed.Median 96 ng/ml. During 18-yr...
We examined whether the risk of premature mortality associated with living in socioeconomically deprived neighborhoods varies according to health status individuals.Community-dwelling adults (n = 566,402; age 50-71 years) 6 US states and 2 metropolitan areas participated ongoing prospective National Institutes Health-AARP Diet Health Study, which began 1995. used baseline data for 565,679 participants on behaviors, self-rated status, medical history, collected by mailed questionnaires....
Smoking and diabetes, consistent risk factors for pancreatic cancer, are also that influence telomere length maintenance. To test whether is associated with cancer risk, we conducted a nested case-control study in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study cohort of male smokers, aged 50-69 years at baseline. Between 1992 2004, 193 incident cases adenocarcinoma occurred (mean follow-up from blood draw: 6.3 years) among participants whole samples available assays. For...
The goal of this study is to summarize trends in rates adverse events attributable acetaminophen use, including hepatotoxicity and mortality.A comprehensive analysis data from three national surveillance systems estimated acetaminophen-related identified different settings, calls poison centers (2008-2012), emergency department visits (2004-2012), inpatient hospitalizations (1998-2011). Rates were calculated per setting, census population, distributed drug units.Rates center with exposures...
Vegetables and fruits are rich in carotenoids, a group of compounds thought to protect against cancer. Studies diet-disease associations need valid reliable instruments for measuring dietary intake. The authors present measurement error model estimate the validity (defined as correlation between self-reported intake "true" intake), systematic error, reliability two self-report assessment methods. Carotenoid exposure is measured by repeated 24-hour recalls, food frequency questionnaire (FFQ),...
Most studies examining associations between circulating vitamin D and disease are based on a single measure of D, which may not reflect levels over time, particularly because concentrations vary by season. Few evaluated how well multiple 25-hydroxyvitamin [25(OH)D] measures track within the same individual time.This study examined variability reproducibility evaluating repeat measurements plasma 25(OH)D while accounting for determinants including dietary supplement use latitude residence...
Although vitamin D deficiency has been noted in cross-sectional studies of chronic liver disease and laboratory suggest possible benefits preventing cancer, little epidemiologic data are available. We performed a nested case–control study the Linxian Nutrition Intervention Trials on participants developing incident cancer or dying from over 22 years follow-up. Baseline serum 25(OH) was measured for 226 cases, 282 deaths 1063 age-, sex- trial-matched controls. Unconditional logistical...
The tree-based scan statistic is a statistical data mining tool that has been used for signal detection with self-controlled design in vaccine safety studies. This disproportionality adjusts multiple testing evaluation of thousands potential adverse events. However, many drug questions are not well suited analysis. We propose method combines statistics propensity score–matched analysis new initiator cohorts, robust investigations safety. conducted plasmode simulations to evaluate...
Abstract This study describes health‐related quality of life (HRQOL) in women previously treated for early stage breast cancer relative to general population and norms. It also identifies correlates multivariate predictors physical mental HRQOL. 2582 who were up four years post‐treatment completed the RAND‐36 Health Survey reported personal cancer‐related information. Participants generally high HRQOL that was comparable norms other with cancer. In analyses, better associated fewer...
Summary Background : Many patients treated with a proton‐pump inhibitor for gastro‐oesophageal reflux disease or erosive oesophagitis still have substantial night‐time gastric acidity. A previous trial of new immediate‐release omeprazole oral suspension suggested that nocturnal acidity could be more effectively controlled bedtime dose than delayed‐release administered before dinner at bedtime. Aim To compare the ability pantoprazole to control acidity, when they were dosed once daily and...