A5101946216- Hippo pathway signaling and YAP/TAZ
- Zebrafish Biomedical Research Applications
- Air Quality and Health Impacts
- Malaria Research and Control
- Cell Adhesion Molecules Research
- Pesticide Exposure and Toxicity
- Sperm and Testicular Function
- Cancer Research and Treatments
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Effects and risks of endocrine disrupting chemicals
- Circular RNAs in diseases
- Protease and Inhibitor Mechanisms
- Energy and Environment Impacts
- SARS-CoV-2 detection and testing
- Virus-based gene therapy research
- Carcinogens and Genotoxicity Assessment
- Connective tissue disorders research
- Reproductive System and Pregnancy
- Reproductive biology and impacts on aquatic species
- Pesticide and Herbicide Environmental Studies
- Aquaculture disease management and microbiota
- Lung Cancer Treatments and Mutations
- Carbon Dioxide Capture Technologies
- Congenital heart defects research
The Ohio State University
2021-2024
National Clinical Research Center for Digestive Diseases
2024
Peking University
2024
State Key Laboratory of Oncogene and Related Genes
2018-2023
Renji Hospital
2018-2023
Shanghai Cancer Institute
2008-2023
Shanghai Jiao Tong University
2018-2023
China University of Mining and Technology
2023
Fudan University
2009-2022
Shanghai Institute of Planned Parenthood Research
2018-2021
The current COVID-19 pandemic urges the extremely sensitive and prompt detection of SARS-CoV-2 virus. Here, we present a Human Angiotensin-converting-enzyme 2 (ACE2)-functionalized gold "virus traps" nanostructure as an SERS biosensor, to selectively capture rapidly detect S-protein expressed coronavirus, such in contaminated water, down single-virus level. Such sensor features extraordinary 106-fold virus enrichment originating from high-affinity ACE2 with S protein well "virus-traps"...
Abstract Background Collagens are the most abundant proteins in extra cellular matrix and important components of tumor microenvironment. Recent studies have showed that aberrant expression collagens can influence cell behaviors. However, their roles hepatocellular carcinoma (HCC) poorly understood. Methods In this study, we screened all 44 collagen members HCC using whole transcriptome sequencing data from public datasets, type IV alpha1 chain (COL4A1) was identified as significantly...
Metal–organic frameworks (MOFs), an emerging class of materials, have been regarded as highly promising adsorbent materials for carbon capture and sequestration (CCS). To date, most reported studies mainly focused on evaluating MOF candidates based their adsorption properties (e.g., selectivity) or performance using a process model. The overall environmental impact this new remains unknown. Several aspects, including the energy load resource depletion from production well other steps in life...
Ambient fine particles (PM2.5) are known to cause various reproductive and developmental diseases. However, the potential mechanisms of PM2.5 exposure induced female damage remain unclear. Four weeks old C57BL/6 J mice were exposed filtered air (FA, n = 10) or concentrated ambient (CAP, using a versatile aerosol concentration enrichment system. After 9 exposure, sacrificed under sevoflurane anesthesia tissue samples collected. Immunohistochemical analysis, enzyme-linked immunosorbent assay,...
Abstract Organophosphates (OPs) and pyrethroids (PYRs) are extensively used pesticides often occur in the form of mixture, whereas little was known about their joint toxicities. We aim to investigate individual effects OPs PYRs exposure on zebrafish embryo by employing chlorpyrifos (CPF) deltamethrin (DM) as representatives. Zebrafish embryos at 2 hours post fertilization (hpf) were exposed CPF (4.80, 39.06, 78.13 μg/L), DM (0.06, 1.60, 3.19 + (4.80 0.06, 39.06 μg/L) until 144 hpf. Embryonic...
Abstract Hepatocellular carcinoma (HCC) is a common and high-mortality cancer worldwide. Numerous microRNAs have crucial roles in the progression of different cancers. However, identifying important target biological function microRNA HCC difficult. In this study, we selected highly expressed with read counts as candidate then tested whether were differentially tumour tissues, found that their expression was related to prognosis. Then, investigated effects on cell growth mobility using...
The rapid onset of resistance to epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) limits its clinical utility in colorectal cancer (CRC) patients, and pan-erb-b2 (ErbB) treatment strategy may be the alternative solution. aim this study was develop a possible microRNA multi-ErbB overcome EGFR-TKI resistance. We detect activity gefitinib-resistant cells, ErbB3/EGFR is significantly activated provides potential target. MiR-323a-3p, tumor suppressor, could target both ErbB3...
The hippo (Hpo) signaling pathway plays a critical role in regulation of organ size.The kinase cascade ultimately antagonizes the transcriptional co-activator Yki/YAP, which is key regulator cell proliferation and apoptosis.In this study, we performed knocking down study using antisense morpholino (MO) reagents found that zebrafish YAP, Hpo pathway, early embryonic development.At cellular level, yap inhibition increases apoptosis decreases proliferation.Reduction function severely delays...
Yunnan and Hainan provinces are the two major endemic regions for Plasmodium falciparum malaria in China. However, few studies have investigated characteristics of this parasite. Therefore, study aimed to evaluate genetic diversity population structure P. predict geographic origin malaria.Thirteen highly polymorphic microsatellite loci were studied estimate 425 isolates obtained from blood samples collected South The analysed diversity, linkage disequilibrium, structure. parasite populations...
Colorectal cancer (CRC) remains a primary cause of mortality globally, necessitating precise prognostic indicators for effective clinical management. Our study introduces the Senescence Risk Score (SRRS), based on several senescence-related genes (SRGs), potent tool designed to measure cellular senescence in CRC. The higher SRRS predicts poorer prognosis, providing novel and efficient approach patient stratification. Notably, we found that correlates with methylation mutation variations,...
Various chemicals released into the aquatic environment adversely affect reproductive system of fish, particularly by changing gonad structure and function. 17alpha-ethinylestradiol (EE2) is a potent environmental estrogen that disrupts sexual differentiation normal reproduction in fish. Previous studies have shown exposure to endocrine-disrupting (EDCs) migration primordial germ cells (PGCs) zebrafish.To investigate effects EE2 on PGC migration, zebrafish embryos were injected with...
Zika virus (ZIKV) was a re-emerging arbovirus associated with Guillain-Barré Syndrome in adult and congenital syndrome fetus infant. Although ZIKV mainly transmitted by mosquito bites, many sexual transmission cases have been reported since the outbreak 2015. can persist testis semen for long time, causing testicular tissue damage reducing sperm quality. However, no drug has approved prevention or treatment of infection, especially infection male tissue. Previously peptide Z2 could...
The current COVID-19 pandemic is motivating us to elucidate the molecular mechanism of SARS-CoV-2 invasion and find methods for decreasing its transmissibility. We found that could increase protein level ACE2 in mice. Folic acid 5-10-methylenetetrahydrofolate reductase (MTHFR) promote methylation promoter inhibit expression. treatment decreased binding ability Spike protein, pseudovirus inactivated authentic host cells. Thus, folic decrease SARS-CoV-2-neutralizing antibody production These...